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Isotopes in the Physical and Biomedical Sciences, vol. 2, Isotopic Applications in NMR Studies.

The very extensive use of both radioactive and stable isotopes, incorporated into compounds for a wide range of studies, has induced interest in a new series entitles Isotopes in the Physical and Biomedical Sciences. Volume 1 of this series dealt with methods of labelling and some specific groups of labelled compounds. Volume 2 concentrates on NMR applications of isotopically labelled compounds. The format chosen for this series consists of selected topics which are reviewed by scientists active in those particular areas, rather than a comprehensive survey of the area. Thus, this volume contains nine separate and self-contained chapters related to NMR applications, entitled: 1. The dynamic and electronic factors in isotope effects on NMR parameters C (C.J. Jameson), 2. 3H NMR studies of hydrogen isotope exchange reactions (P.G. Williams), 3. 2H NMR spectroscopy in partially ordered systems (J.H. Davis), 4. Alkali metal NMR studies of synthetic and natural ionophore complexes (C. Detellier, H.P. Graves and K.M.G Briere), 5. Multinuclear and multipulse NMR of organosilicon compounds (E. Kupce and E. Kukevics), 6. One-bond 13C-13C coupling constants in structural studies (K. Kamienska-Trela), 7. NMR of 6Li-enriched organolithium compounds (R.D. Thomas), 8. NMR as quantitative analytical tool in chemical applications of isotopes (A.D. Bain and L. Lao), and 9. Application of stable isotope labelling and multinuclear NMR to biosynthetic studies (T.J. Simpson).

Isotopic Applications in NMR Studies is a well-constructed book. All the chapters have clear and effective figures, and there are numerous tables presenting an abundance of spectral data. Typographical errors were minimal. Most of the chapters have quite extensive literature reviews up to 1990. A reasonably complete subject index of the overall text is included at the back of the book.

This book is written at the level of research scientist. The methods used and results described are state-of-the-art. The authors are all very knowledgeable and often illustrate key points with results from their own laboratories. I would enthusiastically recommend the book to any organic, inorganic or organometallic chemist who makes extensive use of NMR spectroscopy in their research. On a cautionary note, the series title Isotopes in the Physical and Biomedical Sciences is rather misleading. This volume is largely written by chemists, and for chemists. It does a good job, within this context. However, readers in the physical sciences or biomedical sciences are likely to be somewhat disappointed. For example, there is no mention of major biomedical advances such as the use of double 13C labelling to measure relative metabolic fluxes through competing biochemical pathways in living tissues (the work of S.M. Cohen, etc.) or the incorporation of 15N labelled amino acids into proteins for 3-dimensional and 4-dimensional NMR studies. In addition, the cost of this volume is quite prohibitive (U.S. $274.50), and may not be worth the money unless the reader has a specific interest in one or more of the chapters.
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Author:Brauer, M.
Publication:Canadian Chemical News
Article Type:Book Review
Date:May 1, 1993
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