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Ipsen's First Half 2006 Results.


PARIS Paris, in Greek mythology
Paris or Alexander, in Greek mythology, son of Priam and Hecuba and brother of Hector. Because it was prophesied that he would cause the destruction of Troy, Paris was abandoned on Mt.
 -- Ipsen Ipsen is a European pharmaceutical company headquartered in Paris, France. It primarily develops and markets medications used in oncology, endocrinology and the treatment of neuromuscular disorders. In 2005, Ipsen spent € 169 million—20.  (Paris: IPN IPN Instant Payment Notification (PayPal)
IPN Instituto Politecnico Nacional (México)
IPN Infectious Pancreatic Necrosis
IPN Interplanetary Internet (JPL) 
)

--Results in line with expectations: annual objectives maintained

--Strong cash-flow generation during the period: EUR EUR

In currencies, this is the abbreviation for the Euro.

Notes:
The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion.
 130 million

--Financial flexibility strengthened, with a net cash position of EUR 193 million at 30 June June: see month.  2006

The Board of Directors of Ipsen (Paris: IPN), chaired by Jean-Luc Jean-Luc may refer to:

In politics:
  • Jean-Luc Bennahmias, French politician and Member of the European Parliament
  • Jean-Luc Dehaene, Flemish politician
  • Jean-Luc Mandaba, former Prime Minister of the Central African Republic
 Belingard, met on September September: see month.  5, 2006 to review the Group's first half of 2006 results published today.

First half consolidated con·sol·i·date  
v. con·sol·i·dat·ed, con·sol·i·dat·ing, con·sol·i·dates

v.tr.
1. To unite into one system or whole; combine:
 results summary(1)
(in EUR   million unless
 otherwise stated)               2006      2005(2) % change 2006/2005
-------------------------- ----------- ----------- -------------------
Sales                           430.6       404.1                +6.6%
-------------------------- ----------- ----------- -------------------
Other revenues                   46.6        45.7                +1.9%
-------------------------- ----------- ----------- -------------------
Total revenues                  477.2       449.8                +6.1%
-------------------------- ----------- ----------- -------------------
Operating profit                108.4       115.8               (6.4)%
Operating margin (as a %
 of sales)                       25.2%       28.7%
-------------------------- ----------- ----------- -------------------
Restated operating profit
 (3)                            116.8       115.8                +0.8%
Restated operating margin
 (as a % of sales)               27.1%       28.7%
-------------------------- ----------- ----------- -------------------
Consolidated profit -
 attributable to the Group       88.1        89.4               (1.4)%
-------------------------- ----------- ----------- -------------------
Earnings per share (EUR)
 (4)                             1.05        1.19              (12.0)%
-------------------------- ----------- ----------- -------------------
Average number of shares:
--------------------------
Outstanding                84,013,049  74,936,490
On a diluted basis         84,031,717  74,936,490
-------------------------- ----------- ----------- -------------------
Net cash (debt), end of
 period                         193.3      (153.1)
-------------------------- ----------- ----------- -------------------


(1) Ipsen's auditors AUDITORS, practice. Persons lawfully appointed to examine and digest accounts referred to them, take down the evidence in writing, which may be lawfully offered in relation to such accounts, and prepare materials on which a decree or judgment may be made; and to report the whole, together  have performed a limited review of these financial statements.

(2) The 30 June 2005 pro forma As a matter of form or for the sake of form. Used to describe accounting, financial, and other statements or conclusions based upon assumed or anticipated facts.

The phrase pro forma
 income statement as shown above differs from that published in the 31 December December: see month.  2005 "Document de Base". In compliance with IFRS IFRS International Financial Reporting Standard(s)
IFRS Inter Frame Relay Service
IFRS Indiana Facilities Registry System
 5 the Group's primary care business in Spain Spain, Span. España (āspä`nyä), officially Kingdom of Spain, constitutional monarchy (2005 est. pop. 40,341,000), 194,884 sq mi (504,750 sq km), including the Balearic and Canary islands, SW Europe. , divested in October October: see month.  2005, has been treated as "discontinued operations Discontinued operations

Divisions of a business that have been sold or written off and that no longer are maintained by the business.
" from 1 January January: see month.  2005, whereas in the financial statements reported for 2005 this business was treated as "discontinued operations" only from 30 September 2005. Such restated information presents comparable data over the two periods reported as at 30 June 2006.

(3) In order to better assess the Group's operating performance, the restated operating profit Operating profit (or loss)

Revenue from a firm's regular activities less costs and expenses and before income deductions.


operating profit

See operating income.
 for the first half of 2006 excludes an EUR 8.4 million one-off (1) One at a time. CD-ROM recorders (CD-R drives) are commonly called one-off machines because they write one CD-ROM at a time.

(2) Only once. Software that is written to solve a specific problem only one time is sometimes called a one-off.
 expense paid in March 2006 to Inamed for the recovery of all rights related to Reloxin(R)

(4) On a diluted di·lute  
tr.v. di·lut·ed, di·lut·ing, di·lutes
1. To make thinner or less concentrated by adding a liquid such as water.

2. To lessen the force, strength, purity, or brilliance of, especially by admixture.
 basis.

Review of first half results

For the first half of 2006, consolidated sales grew by 6.6% year-on-year. This increase was fuelled by the growth of products in targeted therapeutic areas (oncology oncology /on·col·o·gy/ (ong-kol´ah-je) the sum of knowledge regarding tumors; the study of tumors.

on·col·o·gy
n.
, endocrinology endocrinology

Medical discipline dealing with regulation of body functions by hormones and other biochemicals and treatment of endocrine system imbalances. In 1841 Friedrich Gustav Henle first recognized “ductless glands,” which secrete products directly into
, neuromuscular neuromuscular /neu·ro·mus·cu·lar/ (-mus´ku-ler) pertaining to nerves and muscles, or to the relationship between them.

neu·ro·mus·cu·lar
adj.
1.
 disorders A
  • Adenoid disorders
  • Adrenal disorders
  • Allergic disorders
  • Anorectal disorders
  • Anxiety disorders
  • Appendix disorders
  • Articulation disorders
  • Attention Deficit Disorder
  • Autonomic nerve disorders
B
  • Balance disorders
) and strong sales momentum in international markets, despite downward price pressures in Major Western European European

emanating from or pertaining to Europe.


European bat lyssavirus
see lyssavirus.

European beech tree
fagussylvaticus.

European blastomycosis
see cryptococcosis.
 Countries negatively impacting sales by EUR 14.3 million over the period.

Other revenues in the first half of 2006 totalled EUR 46.6 million, up 1.9% compared with EUR 45.7 million in the first half of 2005, which included EUR 10.0 million income resulting from the termination The point where a line, channel or circuit ends. See SCSI termination and hybrid.  of a research contract.

Operating income Operating Income

The profit realized from a business' own operations.

Notes:
This would not include income from things such as investments in other firms. Also referred to as operating profit or recurring profit.
 for the first half of 2006 was EUR 108.4 million, representing 25.2% of sales, down 6.4% from a high baseline The horizontal line to which the bottoms of lowercase characters (without descenders) are aligned. See typeface.

baseline - released version
 in 2005 (first half of 2005, EUR 115.8 million representing 28.7% of sales), when R&D and commercial costs in 2005 were particularly back-loaded in the second half of that year. Restated for an EUR 8.4 million one-off expense paid in March 2006 to Inamed for the recovery of all rights related to Reloxin(R), the Group's operating profit in the first half of 2006 stood at EUR 116.8 million, stable year-on-year despite severe price pressure in major European countries, to reach 27.1% of sales compared with 28.7% a year ago. This 1.6 points decrease in restated operating margin Operating Margin

A ratio used to measure a company's pricing strategy and operating efficiency.

Calculated by:
 as a percentage of sales notably includes (i) a continued improvement of 0.3 points in cost of goods sold Cost of goods sold

The total cost of buying raw materials, and paying for all the factors that go into producing finished goods.


cost of goods sold 
 due to a better product mix, (ii) an increase of 0.8 points in R&D expenses due to the preparation of filings for Somatuline(R) Autogel(R) and Dysport(R) in the US plus finalisation n. 1. same as finalization.

Noun 1. finalisation - the act of finalizing
finalization

mop up, windup, completion, culmination, closing - a concluding action
 of the BIM BIM Building Information Modeling
BIM Building Information Model
BIM Bord Iascaigh Mhara (Irish Sea Fisheries Board)
BIM Brussels Instituut voor Milieubeheer (Belgium)
BIM Bharathidasan Institute of Management
 51077 (GLP-1 analogue (electronics) analogue - (US: "analog") A description of a continuously variable signal or a circuit or device designed to handle such signals. The opposite is "discrete" or "digital". ) development programme and (iii) an increase of 0.6 points in SG&A mainly resulting from an increase in sales taxes sales tax, levy on the sale of goods or services, generally calculated as a percentage of the selling price, and sometimes called a purchase tax. It is usually collected in the form of an extra charge by the retailer, who remits the tax to the government.  in France and in costs of certain corporate functions - notably expenses in respect of stock exchange listing requirements Listing requirements

Requirements, including minimum shares outstanding, market value, and income, that are laid down by an exchange for any stock to be listed for trading.
 - partially offset by productivity improvements in sales and marketing expenses.

The consolidated profit attributable attributable

emanating from or pertaining to attribute.


attributable proportion
see attributable risk (below).

attributable risk
 to the Group amounted to EUR 88.1 million in the first half of 2006, representing 18.5% of revenues, compared with 19.9% a year earlier.

The Group generated a strong EUR 130.2 million cash flow from operating activities, against EUR 62.5 million a year earlier. Cash flow in the first half of 2006 benefited from sustained activity during the period as well as from payments of milestones by Medicis under the Reloxin(R) distribution licence granted by the Group for the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. , Canada Canada (kăn`ədə), independent nation (2001 pop. 30,007,094), 3,851,787 sq mi (9,976,128 sq km), N North America. Canada occupies all of North America N of the United States (and E of Alaska) except for Greenland and the French islands of  and Japan in the aesthetics aesthetics (ĕsthĕt`ĭks), the branch of philosophy that is concerned with the nature of art and the criteria of artistic judgment.  indication. As a result, the Group has reimbursed most of its credit facilities credit facilities nplfacilidades fpl de crédito

credit facilities nplfacilités fpl de paiement

credit facilities 
, in addition to utilising EUR 25.2 million for its investment transactions and paying out EUR 50.4 million in dividends during the half-year. Overall, the first half of 2006 showed a net increase in cash flow of EUR 24.2 million compared to a decrease of EUR 55.6 million for the same period a year ago.

Financial objectives for 2006 full year

The Group's performance in the first half of 2006 is consistent with management expectations and enables the Group to confirm its financial objectives set out for the full year of 2006:

--Sales growth of 6.5% to 7.5%

--Operating margin of 21.5% to 22.0% of sales(1)(1)

--Based on the guidance issued by Tercica This article or section needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article.  on its 2006 financial results, and assuming completion of Ipsen's acquisition of 25% of Tercica's equity in early October 2006, Ipsen's financial statements in 2006 could also include an additional c.EUR 4 million charge(2)(2)("income/loss from associates ").

Commenting on the performance in the first half of 2006, Jean-Luc Belingard, Chairman and Chief Executive Officer of Ipsen, stated: "These results confirm the soundness of Ipsen's strategic focus: strong growth in targeted therapeutic areas and strong operating margins generating strong cash-flows. This allows us to confirm our full year 2006 objectives".

(1) including the negative impact of a non-recurring expense of EUR 8.4 million paid to Inamed and excluding any potential loss from associates arising from Tercica.

(2) Assuming Tercica's net loss during the second half of 2006 is spread evenly between the third and fourth quarters of 2006.

Regarding Ipsen's evolution since the beginning of 2006, Mr Belingard said: "We have significantly reshaped Ipsen's profile, notably by expanding its marketing reach and overall market coverage worldwide: we have gained exposure to the aesthetic aes·thet·ic or es·thet·ic
adj.
1. Relating to the sensations.

2. Relating to esthetics.
 market through our partnership with Medicis in North America North America, third largest continent (1990 est. pop. 365,000,000), c.9,400,000 sq mi (24,346,000 sq km), the northern of the two continents of the Western Hemisphere.  and, subject to completion, we are building with Tercica our platform to market Somatuline(R) in the US whilst preserving our profitability profile. We have also broadened our product portfolio with the addition of Increlex(R) to our endocrinology offering in Europe Europe (yr`əp), 6th largest continent, c.4,000,000 sq mi (10,360,000 sq km) including adjacent islands (1992 est. pop. 512,000,000). . Last but not least, Somatuline(R) Autogel(R) has been approved in Canada, the first time ever one of our products has been registered in North America".

Mr Belingard added: "Since December 2005, we have achieved our objectives for the period. The second half of 2006 will be another important period for Ipsen, with the expected filings of febuxostat Febuxostat is an inhibitor of xanthine oxidase currently under investigation as a potential treatment for gout.[1] References

1. ^ Stamp LK, O'Donnell JL, Chapman PT (2007).
 in Europe and Somatuline(R) Autogel(R) in the US in the fourth quarter. We are also progressing our discussions with potential distributors for our botulinum toxin Botulinum toxin (botulin)
A neurotoxin made by Clostridium botulinum; causes paralysis in high doses, but is used medically in small, localized doses to treat disorders associated with involuntary muscle contraction and spasms, in addition to strabismus.
 product in aesthetic use in Europe. Furthermore, we are continuing to investigate potential acquisitions of late-stage products, as well as seeking R&D partnerships for some of our early-stage products. Going forward, we intend to continue to unfold unfold - inline  our strategy, capitalizing on our R&D capabilities and our market positioning in order to grow Ipsen into a tier-1 international specialty A contract under seal.

A specialty is a written document that has been sealed and delivered and is given as security for the payment of a specifically indicated debt.
 pharmaceutical company enjoying sustained profitable growth".

A review of the financial position and results in Ipsen's consolidated financial statements Consolidated Financial Statements

The combined financial statements of a parent company and its subsidiaries.

Notes:
Because consolidated financial statements present an aggregated look at the financial position of a parent and its subsidiaries, they enable you to gauge
 for the half-year ended 30 June 2006 and 30 June 2005 is attached to this press release.

Conferences Calls

Conference call Media (in French)

Ipsen will host a conference call on Wednesday Wednesday: see week.  6 September at 10.00 a.m. (Paris time).

Callers should dial in approximately ap·prox·i·mate  
adj.
1. Almost exact or correct: the approximate time of the accident.

2.
 5 to 10 minutes prior to the start of the call. No reservation A clause in a deed of real property whereby the grantor, one who transfers property, creates and retains for the grantor some right or interest in the estate granted, such as rent or an Easement ,a right of use over the land of another.  is necessary to participate in the call. The telephone number to join the conference call is +33 (0)1 71 23 04 21 . Please mention the company name (Ipsen) and our CEO's name (Jean-Luc Belingard) to the operator. No access code is necessary for the live call.

A replay will be available soon after the live call. The telephone number to access the replay is +33 (0)1 71 23 02 48. The access code is 5482558#. The replay will be available for one week following the live call.

Conference call Analysts and webcat (in English 1. English - (Obsolete) The source code for a program, which may be in any language, as opposed to the linkable or executable binary produced from it by a compiler. The idea behind the term is that to a real hacker, a program written in his favourite programming language is )

Ipsen will host a conference call on Wednesday 6 September at 3.00 p.m. (Paris time). A live webcast will be available at www.ipsen.com. The webcast will be archived on the Ipsen website for 3 months following the live call.

Callers should dial in approximately 5 to 10 minutes prior to the start of the call. No reservation is necessary to participate in the call. The telephone numbers to join the conference call are, from France and Europe: +33 (0)1 71 23 04 21 and from the United States: +1 718 354 1362.

Please mention the company name (Ipsen) and our CEO's name (Jean-Luc Belingard) to the operator. No access code is necessary for the live call.

A replay will be available soon after the live call. The telephone numbers to access the replay are, from France and Europe: +33 (0)1 71 23 02 48 and from the United States: +1 718 354 1112. The access code is 9210426#. The replay will be available for one week following the live call.

About Ipsen

Ipsen is a European pharmaceutical group with over 20 products on the market and a total worldwide staff of nearly 4,000. The company's development strategy is based on a combination of products in targeted therapeutic areas (oncology, endocrinology and neuromuscular disorders) which are growth drivers, and primary care products which contribute significantly to its research financing. This strategy is also supported by an active policy of partnerships. The location of its four R&D centres (Paris, Boston Boston, town, England
Boston, town (1991 pop. 26,495), E central England, on the Witham River. Boston's fame as a port dates from the 13th cent., when it was a Hanseatic port trading wool and wine. Having recovered from a decline in the 18th and 19th cent.
, Barcelona Barcelona (bär'səlō`nə, Catalan bär'səlō`nə, Span. bär'thālō`nä), city (1990 pop. 4,738,354), capital of Barcelona prov. and chief city of Catalonia, NE Spain, on the Mediterranean Sea. , London London, city, Canada
London, city (1991 pop. 303,165), SE Ont., Canada, on the Thames River. The site was chosen in 1792 by Governor Simcoe to be the capital of Upper Canada, but York was made capital instead. London was settled in 1826.
) gives the Group a competitive edge in gaining access to leading university research teams and highly qualified personnel. In 2005, Research and Development expenditure was EUR 169.0 million, i.e. 20.9% of consolidated sales, which amounted to EUR 807.1 million in the Group's pro forma accounts prepared in accordance Accordance is Bible Study Software for Macintosh developed by OakTree Software, Inc.[]

As well as a standalone program, it is the base software packaged by Zondervan in their Bible Study suites for Macintosh.
 with IFRS. Nearly 700 people in R&D are dedicated to the discovery and development of innovative drugs for patient care. Ipsen's shares are traded on Segment A of Eurolist by Euronext Euronext N.V. is a pan-European stock exchange based in Paris[1] (TM) (stock code: IPN, ISIN Isin (ĭs`ĭn), capital of an ancient Semitic kingdom of N Babylonia. The city became important after the third dynasty of Ur fell to the Elamites and the Amorites (c.2025 B.C.). The phase from c.2025–c.1763 B.C.  code: FR0010259150). For more information on Ipsen, visit our website at www.ipsen.com.

Forward-looking statements forward-looking statement

A projected financial statement based on management expectations. A forward-looking statement involves risks with regard to the accuracy of assumptions underlying the projections.


The forward-looking statements and targets contained herein are based on Ipsen's management's current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein.

Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances CIRCUMSTANCES, evidence. The particulars which accompany a fact.
     2. The facts proved are either possible or impossible, ordinary and probable, or extraordinary and improbable, recent or ancient; they may have happened near us, or afar off; they are public or
 on which any such statements are based, unless so required by applicable law. Ipsen's business is subject to the risk factors outlined in its information documents filed with the French Autorite des marches financiers.
For further information :

Didier Veron, Director of Public Affairs and Corporate Communications
Tel.: +33 (0)1 44 30 42 38 - Fax: +33 (0)1 44 30 42 04
E-mail : didier.veron@ipsen.com

David Schilansky, Investor Relations Officer
Tel.: +33 (0)1 44 30 43 31 - Fax: +33 (0)1 44 30 43 21
E-mail: david.schilansky@ipsen.com


1 - Comparison of the consolidated income statement consolidated income statement

An income statement that combines the income statements of two or more organizations. As with other consolidated statements, a consolidated income statement eliminates any funds owed to or due from firms within the same group.
 for the half-years ended 30 June 2006 and 30 June 2005

A comparison of the income statement is presented below:
30 June 2006
                                  ------------------------------------
                                  (in thousands of    % of revenues
                                        euros)
--------------------------------------------------- ------------------
Sales                                      430,607              90.2 %
Other revenues                              46,569               9.8 %
Total revenues                             477,176             100.0 %
Cost of goods sold                         (88,879)            -18.6 %
Research and development expenses          (83,817)            -17.6 %
Selling, general and
 administrative expenses                  (188,000)            -39.4 %
Other operating income and
 expenses                                   (8,298)             -1.7 %
Restructuring costs                            189                 n/s
Impairment losses                                -                  -
Operating profit                           108,371              22.7 %
- Income from cash and cash
 equivalents                                 2,767
- Cost of gross financial debt              (1,208)
Cost of net financial debt                   1,559               0.3 %
Other interest income and expense           (1,202)             -0.3 %
Income tax                                 (20,280)             -4.3 %
Profit from continuing operations           88,448               18.5%
Profit from discontinued                                           n/s
 operations                                     33
Consolidated profit                         88,481               18.5%
- Attributable to equity holders
 of Ipsen S.A.                              88,144
- Minority interests                           337
--------------------------------------------------- ------------------


                                30 June 2005             30 June 2005
                                pro forma (1)            pro forma
                                                         as reported
                     ----------------------------------- -------------
                        (in         % of     2006/2005   (in thousands
                      thousands    revenues   variation    of euros)
                      of euros)
------------------------------- ----------- ------------ -------------
Sales                  404,099       89.8 %        6.6 %      412,704
Other revenues          45,684       10.2 %        1.9 %       45,684
Total revenues         449,783      100.0 %        6.1 %      458,388
Cost of goods sold     (84,437)     -18.8 %        5.3 %      (88,961)
Research and
 development expenses  (75,565)     -16.8 %        10.9%      (75,635)
Selling, general and
 administrative
 expenses             (174,166)     -38.7 %        7.9 %     (177,317)
Other operating                         n/s          n/s
 income and expenses       174                                    174
Restructuring costs          -           -           n/s            -
Impairment losses            -           -           n/s            -
Operating profit       115,789       25.7 %        -6.4%      116,649
- Income from cash
 and cash equivalents    1,089                                  1,089
- Cost of gross
 financial debt         (4,378)                                (4,378)
Cost of net financial
 debt                   (3,289)      -0.7 %     -147.4 %       (3,289)
Other interest income
 and expense            (1,348)      -0.3 %       -10.8%       (1,348)
Income tax             (22,256)      -4.9 %        -8.9%      (22,433)
Profit from
 continuing
 operations             88,896       19.8 %        -0.5%       89,579
Profit from
 discontinued                                        n/s
 operations                683        0.2 %                         -
Consolidated profit     89,579       19.9 %       -1.2 %       89,579
- Attributable to
 equity holders of
 Ipsen S.A.             89,368                                 89,368
- Minority interests       211                                    211
------------------------------- ----------- ------------ -------------


(1) The 30 June 2005 pro forma income statement as shown above differs from that published in the 31 December 2005 "Document de Base". In compliance with IFRS 5 the Group's primary care business in Spain, divested in October 2005, has been treated as "discontinued operations" from 1 January 2005, whereas in the financial statements reported for 2005 this business was treated as "discontinued operations" only from 30 September 2005. Such restated information presents comparable data over the two half-years reported as at 30 June 2006.

--Sales

For the first half of 2006, consolidated sales grew by 6.6% year-on-year. This increase was fuelled by the growth of products in targeted therapeutic areas (oncology, endocrinology, neuromuscular disorders) and strong sales momentum in international markets, despite downward price pressures in Major Western European Countries negatively impacting sales by EUR 14.3 million over the period.

--Other revenues

In the first half of 2006, other revenues, which include royalties Not to be confused with Royal family.

Royalties (sometimes, running royalties) are usage-based payments made by one party (the "licensee") to another (the "licensor") for ongoing use of an asset, most typically an intellectual property (IP) right.
 and milestone “Milemarker” redirects here. For the American indie rock band, see Milemarker (band).

A milestone or kilometre sign is one of a series of numbered markers placed along a road at regular intervals, typically at the side of the road or in a median.
 payments from partners and for various services, totalled EUR 46.6 million, up 1.9% year-on-year (first half of 2005, EUR 45.7 million).

Other revenues break down into half-years as follows:
30 June    30 June      2006/2005
(in thousands of euros)            2006        2005       variation
                                            pro forma  Amount        %
------------------------------- ---------- ----------- ------- -------
Breakdown by revenue type
- Royalties received               21,865      22,684    (819)   -3.6%
- Milestone payments                4,128          60   4,068       ns
- Licensing agreements              6,717      16,033  (9,316)      ns
- Other (co-promotion revenues,
 recharging)                       13,859       6,907   6,952  100.6 %
------------------------------- ---------- ----------- ------- -------
Total other revenues               46,569      45,684     885    1.9 %
------------------------------- ---------- ----------- ------- -------


--Royalties received mainly comprised royalties from the Kogenate(R) licence, which amounted to EUR 20.2 million for the first half of 2006 (first half of 2005, EUR 21.1 million). The first quarter of 2005 had been particularly high due to the carry-over The designation of the process by which net operating loss for one year may be applied, as provided by federal tax law, to each of several taxable years following the taxable year of such loss.  of some 2004 royalties into the first half of 2005.

--Milestone payments represent recognition of payments received over the life of contracts. In the first half of 2006, this income mainly comprised the milestones in relation to the Reloxin(R) and Tenstaten(R) agreements.

--In the first half of 2006, licensing agreements mainly comprised the recognition of advance payments made by Roche n. 1. Rock.  as a result of the BIM 51077 partnership. In the first half of 2005, income of EUR 10.0 million was recorded in connection with the termination of a research contract.

--The increase in other revenues during the first half of 2006 was due to higher billings Billings, city (1990 pop. 81,151), seat of Yellowstone co., S Mont., on the Yellowstone River, in a valley surrounded by seven mountain ranges; inc. as a city 1885.  for R&D services within the framework of existing partnerships as well as an increase in co-promotion Co-promotion is a marketing practice where a company in addition to its own, uses another company's sales force to promote the same brand or range of brands. The term is frequently confused with Co-marketing. See also
Marketing co-operation
 revenues, notably related to the early termination in April 2006 of the co-promotion contract for Zoxan with Pfizer Pfizer Incorporated (NYSE: PFE) is a major research-based pharmaceutical company, which ranks number two in sales The company is based in New York City. It produces the number-one selling drug Lipitor (atorvastatin, used to lower blood cholesterol); the oral antifungal , which was initially due to expire expire /ex·pire/ (ek-spi´er)
1. to exhale.

2. to die.


ex·pire
v.
1. To breathe one's last breath; die.

2. To exhale.
 on 30 November November: see month.  2006.

--Cost of goods sold

In the first half of 2006, cost of goods sold amounted to EUR 88.9 million, representing 20.6% of sales. By comparison, in the same period of 2005, cost of goods sold amounted to EUR 84.4 million, representing 20.9% of sales. This favourable trend was mainly due to increased production volumes and a favourable product mix, despite the negative impact of price cuts during the first half of 2006.

--Research and development expenses

A comparison of research and development expenses for the half-years ended 30 June 2006 and 30 June 2005 is presented in the following table:
30 June    30 June      2006/2005
(In thousands of euros)            2006     2005 pro      variation
                                             forma
                                                       Amount        %
------------------------------------------ ----------- ------- -------
Breakdown by expense type
- Drug-related research and
 development(1)                    70,645      65,613   5,032    7.7 %
- Industrial development(2)        10,218       7,518   2,700   35.9 %
- Strategic development(3)          2,954       2,434     520   21.4 %
------------------------------------------ ----------- ------- -------
Total                              83,817      75,565   8,252   10.9 %
------------------------------------------ ----------- ------- -------


(1) Drug-related research and development is aimed at identifying new agents, determining their biological characteristics and developing small-scale small-scale
adj.
1. Limited in scope or extent; modest: a small-scale plan.

2. Created on a small scale:
 manufacturing processes. Pharmaceutical development is the process through which active agents become regulatorily-approved drugs and is also used to improve existing drugs and to research new therapeutic indications for them. Patent-related costs are included in this type of expense.

(2) Includes chemical, biotechnical and development-process research costs to industrialise Verb 1. industrialise - organize (the production of something) into an industry; "The Chinese industrialized textile production"
industrialize

alter, change, modify - cause to change; make different; cause a transformation; "The advent of the automobile may
 the small-scale production of agents developed by the research laboratories.

(3) Includes costs incurred for research into new product licences or establishing partnership agreements.

Research and development expenses increased by 10.9% to EUR 83.8 million, representing 17.6% of total revenues and 19.5% of sales for the half-year to 30 June 2006. That compares with the half-year to 30 June 2005, when research and development expenses totalled EUR 75.6 million, representing 16.8% of total revenues and 18.7% of sales.

--In 2006, major research and development projects included the continuation continuation - continuation passing style  of phase III clinical trials Noun 1. phase III clinical trial - a large clinical trial of a treatment or drug that in phase I and phase II has been shown to be efficacious with tolerable side effects; after successful conclusion of these clinical trials it will receive formal approval from the  for Somatuline(R) and Dysport(R) with a view to preparing for their filing with the Food and Drug Administration in the USA ("FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
"), as well as the finalisation of the BIM 51077 development programmes agreed within the partnership with Roche. The growth in drug-related research and development expenses particularly reflects the full-period impact of the Group having strengthened its clinical development teams, starting in 2004.

--In the area of industrial development, the increase during the first half of 2006 in industrial development expenses is mainly linked to costs required for the preparation for pre-approval In lending, pre-approval has two meanings:

1. The first is that a lender, via public or proprietary information, feels that a potential borrower is completely credit worthy enough for a certain credit product, and approaches the potential customer with a guarantee that
 inspections by the FDA in some of the Group's manufacturing sites, to prepare for future launches of Dysport(R) and Somatuline(R) in the USA.

--Selling, general and administrative expenses

A comparison of selling, general and administrative expenses for the half-years ended 30 June 2006 and 30 June 2005 is presented in the following table:
30 June    2006/2005
                                      30 June    2005      variation
                                        2006     pro
(In thousands of euros)                          forma  Amount       %
---------------------------------------------- -------- ------- ------
Breakdown by expense type
  Royalties paid                       15,839   14,088   1,751  12.4 %
  Taxes and sales tax                   7,548    5,828   1,720  29.5 %
  Other sales and marketing expenses  127,221  121,578   5,643   4.6 %
---------------------------------------------- -------- ------- ------
Selling expenses                      150,608  141,494   9,114   6.4 %
---------------------------------------------- -------- ------- ------
General and administrative expenses    37,392   32,672   4,720  14.4 %
---------------------------------------------- -------- ------- ------
Total                                 188,000  174,166  13,834   7.9 %
---------------------------------------------- -------- ------- ------


For the first half of 2006 , selling, general and administrative expenses increased by 7.9% to EUR 188.0 million, representing 43.7% of sales compared with EUR 174.2 million a year ago (representing 43.1% of sales).

--Selling expenses amounted to EUR 150.6 million, or 35.0% of sales for the first half of 2006, a flat rate year-on-year (first half of 2005, EUR 141.5 million representing 35.0% of sales). Selling expenses include royalties paid to third parties on the sales of products marketed by the Group amounting to EUR 15.8 million for the first half of 2006, up 12.4% year-on-year, stemming stemming - stemmer  from the sales growth of the corresponding products. Taxes and sales taxes for the first half of 2006 were up 29.5% at EUR 7.5 million, mainly due to an increase of sales tax in France to 1.76% imposed on 1 January 2006, up from 0.6% a year ago. For the first half of 2006, other sales and marketing expenses amounted to EUR 127.2 million, up 4.6% from EUR 121.6 million for the same period a year ago. This increase is significantly below the sales growth level, and reflects the success of the Group's productivity improvement programmes.

--General and administrative expenses grew by 14.4% to EUR 37.4 million for the first half of 2006, representing an increase of EUR 4.7 million from a year ago. This evolution stemmed stemmed  
adj.
1. Having the stems removed.

2. Provided with a stem or a specific type of stem. Often used in combination: stemmed goblets; long-stemmed roses.
 mainly from an increase in costs of corporate functions, notably due to the stock exchange listing of the Group, as well as reinforcement reinforcement /re·in·force·ment/ (-in-fors´ment) in behavioral science, the presentation of a stimulus following a response that increases the frequency of subsequent responses, whether positive to desirable events, or  of certain administrative functions of the Group related to its expansion in international markets.

--Other operating income and expenses

For the first half of 2006, other operating income and expenses amounted to an EUR 8.3 million expense compared with EUR 0.2 million income a year ago. In 2006, this amount essentially comprises a non-recurring payment of USD USD

In currencies, this is the abbreviation for the U.S. Dollar.

Notes:
The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion.
10.0 million to Inamed for the recovery of all rights related to Reloxin(R) in the United States, Canada and Japan in accordance with the termination agreement between the Group and Inamed.

--Operating profit

Operating income for the first half of 2006 was EUR 108.4 million, representing 25.2% of sales, down 6.4% from a high baseline in 2005 (first half of 2005, EUR 115.8 million representing 28.7% of sales), when R&D and commercial costs were particularly back-loaded into the second half of the year.

Restated for an EUR 8.4 million one-off expense paid in March 2006 to Inamed for the recovery of all rights related to Reloxin(R), the Group's operating profit in the first half of 2006 stood at EUR 116.8 million, stable year-on-year despite severe price pressure in major European countries, representing 27.1% of sales compared with 28.7% a year ago. This 1.6 points decrease in restated operating profit as a percentage of sales notably includes (i) a continued improvement of 0.3 points in cost of goods sold due to a better product mix, (ii) an increase of 0.8 points in R&D expenses due to the preparation of the filings for Somatuline(R) Autogel(R) and Dysport(R) in the US plus finalisation of the BIM 51077 (GLP-1 analogue) development programme and (iii) an increase of 0.6 points in SG&A mainly resulting from an increase in sales taxes in France and in costs of certain corporate functions - notably stock exchange listing requirements expenses - partially offset by productivity improvements in other sales and marketing expenses.

Segment reporting segment reporting

A type of financial reporting in which the firm discloses information by identifiable industry segments. For example, Union Pacific Corporation reports revenues, income, assets, depreciation, and capital expenditures for each of four
: Operating profit by geographical ge·o·graph·ic   also ge·o·graph·i·cal
adj.
1. Of or relating to geography.

2. Concerning the topography of a specific region.



ge
 region

In compliance with IAS See iPlanet Application Server.

1. (computer) IAS - The first modern computer. It had main registers, processing circuits, information paths within the central processing unit, and used Von Neumann's fetch-execute cycle.
 14 "Segment Reporting", the Group's primary reporting format is presented according to according to
prep.
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

3.
 geographical segment, since Ipsen operates in a single business segment, i.e. drug research and development, production and sales.

Sales, revenues and operating profit for the half-years ended 30 June 2006 and 30 June 2005 are presented in the following table by geographical region:
30 June 2006         30 June 2005
                                                       pro forma

                                (in                  (in
                              thousands            thousands
                             of euros)          %  of euros)         %
---------------------------- ---------- --------- ---------- ---------
Major Western European
 countries (1)
Sales                          275,645     96.3 %   273,927     97.8 %
Revenues                       286,345    100.0 %   280,052    100.0 %
Operating profit               113,110     39.5 %   114,745     41.0 %
---------------------------- ---------- --------- ---------- ---------
Other European countries
Sales                           93,324    100.0 %    79,047     99.8 %
Revenues                        93,324    100.0 %    79,218    100.0 %
Operating profit                40,372     43.3 %    29,440     37.2 %
---------------------------- ---------- --------- ---------- ---------
Rest of the World
Sales                           61,638    100.0 %    51,125    100.0 %
Revenues                        61,638    100.0 %    51,125    100.0 %
Operating profit                24,375     39.5 %    15,924     31.1 %
---------------------------- ---------- --------- ---------- ---------
Allocated Total
Sales                          430,607     97.6 %   404,099     98.5 %
Revenues                       441,307    100.0 %   410,395    100.0 %
Operating profit               177,857     40.3 %   160,109     39.0 %
---------------------------- ---------- --------- ---------- ---------
Non-Allocated Total
Revenues                        35,869    100.0 %    39,388    100.0 %
Operating loss                 (69,486) (193.7) %   (44,320) (112.5) %
---------------------------- ---------- --------- ---------- ---------
Ipsen Total
Sales                          430,607     90.2 %   404,099     89.8 %
Revenues                       477,176    100.0 %   449,783    100.0 %
Operating profit               108,371     22.7 %   115,789     25.7 %
---------------------------- ---------- --------- ---------- ---------


                                        2006/2005 variation

                              (in thousands of
                                    euros)                           %
---------------------------- -------------------- --------------------
Major Western European
 countries (1)
Sales                                      1,718                 0.6 %
Revenues                                   6,293                 2.2 %
Operating profit                          (1,635)              (1.4) %
---------------------------- -------------------- --------------------
Other European countries
Sales                                     14,277                18.1 %
Revenues                                  14,106                17.8 %
Operating profit                          10,932                37.1 %
---------------------------- -------------------- --------------------
Rest of the World
Sales                                     10,513                20.6 %
Revenues                                  10,513                20.6 %
Operating profit                           8,451                53.1 %
---------------------------- -------------------- --------------------
Allocated Total
Sales                                     26,508                 6.6 %
Revenues                                  30,912                 7.5 %
Operating profit                          17,748                11.1 %
---------------------------- -------------------- --------------------
Non-Allocated Total
Revenues                                  (3,519)              (8.9) %
Operating loss                           (25,166)             (56.8) %
---------------------------- -------------------- --------------------
Ipsen Total
Sales                                     26,508                 6.6 %
Revenues                                  27,393                 6.1 %
Operating profit                          (7,418)              (6.4) %
---------------------------- -------------------- --------------------


(1) France, Spain, Italy Italy (ĭt`əlē), Ital. Italia, officially Italian Republic, republic (2005 est. pop. 58,103,000), 116,303 sq mi (301,225 sq km), S Europe. , Germany Germany (jûr`mənē), Ger. Deutschland, officially Federal Republic of Germany, republic (2005 est. pop. 82,431,000), 137,699 sq mi (356,733 sq km).  and the UK

--In the Major Western European countries, sales for the first half of 2006 grew by only 0.6% year-on-year. This mainly reflects government measures imposing price cuts, together with the impact of the Tenstaten(R) agreement with Recordati in France. Moreover, in the first half of 2006, sales taxes increased by nearly EUR 2 million year-on-year, mainly in France. As a result, the operating profit declined by 1.4% to EUR 113.1 million for the first half of 2006, representing 39.5% of revenues, against EUR 114.7 million a year ago, representing 41.0% of revenues.

--In Other European countries, which include other Western European countries and Eastern Europe Eastern Europe

The countries of eastern Europe, especially those that were allied with the USSR in the Warsaw Pact, which was established in 1955 and dissolved in 1991.
 countries, the operating profit for the period increased by 37.1% to EUR 40.4 million, compared with EUR 29.4 million a year earlier. This good performance was achieved due to (i) a strong 18.1% sales increase despite a EUR 3.3 million impact of price reductions, (ii) a reduction in sales taxes and commissions in some countries and (iii) the absence of non-recurring expenses in the first half of 2006, which had impacted the first half of 2005. As a result, operating profit in the region for the first half of 2006 represents 43.3% of revenues, against 37.2% a year ago.

--In the Rest of the World, most of the Group's products are marketed by third-party distributors Third-Party Distributor

The name given to institutions that sell or distribute mutual funds to investors for fund management companies without direct relation to the fund itself.
 and agents, except in China and South Korea Korea (kôrē`ə, kə–), Korean Hanguk or Choson, region and historic country (85,049 sq mi/220,277 sq km), E Asia. , where Ipsen has a direct presence. For the first half of 2006, operating profit sharply increased to EUR 24.4 million, up 53.1% year-on-year (first half of 2005, EUR 15.9 million) due to a strong 20.6% increase in sales, while costs have not increased at the same pace.

Non-allocated operating loss operating loss

The excess of operating expenses over revenue. As with operating income, operating losses exclude revenues and expenses from operations that are not considered a regular part of the business. Also called deficit. Compare operating income.
 for the first half of 2006 totalled EUR 69.5 million, against a loss of EUR 44.3 million a year ago. For the first half of 2006, the non-allocated operating loss included:

--revenues of EUR 35.9 million against EUR 39.4 million a year earlier. This decrease is explained by (i) the negative impact of lesser royalties generated by the Kogenate(R) license, (ii) an income received in May 2005 related to the termination of a research agreement and (iii) in the first half of 2006, the positive impact of the recognition of milestones in connection with the Reloxin(R) agreement in addition to higher billings for R&D services in existing partnerships.

--research and development expenses of EUR 75.4 million, up from EUR 68.0 million a year ago.

--selling, general & administrative expenses of EUR 21.8 million, compared with EUR 16.9 million a year ago. This increase results in particular from a reinforcement of some of the Group's corporate functions.

--other expense of EUR 8.1 million, mainly comprising the indemnity Recompense for loss, damage, or injuries; restitution or reimbursement.

An indemnity contract arises when one individual takes on the obligation to pay for any loss or damage that has been or might be incurred by another individual.
 paid to Inamed as shown above, compared with other income of EUR 1.2 million recorded a year ago.

Cost of net financial debt

For the first half of 2006, the cost of net financial debt showed an income of EUR 1.6 million against an expense of EUR 3.3 million a year earlier. This positive trend mainly reflects the strong improvement in the cash position due to the capital increase in December 2005 and the cash received in 2006 from partnerships.

--Income tax

For the first half of 2006, the Group's effective tax rate amounted to 18.7% of pre-tax pre-tax adjanterior al impuesto

pre-tax adjavant impôt(s)

pre-tax adjal lordo d'imposta 
 profit from continuing operations continuing operations

Parts of a business that are expected to be maintained as an ongoing segment of an overall business operation. Income and losses from continuing operations are reported separately if any segments have been discontinued during the
, compared with 20.0% a year earlier.

The Group's effective tax rate benefited in 2006 from the non-recurring tax impact of the use of UK capital losses carried forward for a total of EUR 6.9 million.. Due to uncertainty of recovery of those capital losses, no deferred tax assets had previously been recognized whereas, in 2006, the capital gain deriving de·rive  
v. de·rived, de·riv·ing, de·rives

v.tr.
1. To obtain or receive from a source.

2.
 from the Reloxin(R) agreement with Medicis enabled capital losses to be offset in the period. Excluding this non-recurring impact, the Group's tax rate would have been 25.0% for the half-year to 30 June 2006. A year ago, the Group's effective tax rate had benefited from the non-recurring impacts of recognizing net deferred tax assets and utilizing previously unrecognized tax loss carry forwards in UK and Dutch subsidiaries, since their profitability had improved. Excluding these non-recurring impacts, the Group's effective tax rate for the half-year to 30 June 2005 would have been 24.9%, in line with the first half of 2006.

--Profit from continuing operations

As a result of the items noted above, profit from continuing operations for the first half of 2006 declined by 0.5% to EUR 88.5 million, against EUR 88.9 million a year earlier. Thus profit from continuing operations represented 18.5% of revenues, compared with 19.8% for the first half of 2005.

--Profit from discontinued operations

Profit from discontinued operations relates to toll-manufacturing for Spain-based FAES FAES Foundation for Advanced Education in the Sciences (National Institutes of Health)
FAES Flame Atomic Emission Spectroscopy
 FARMA FARMA National Farmers' Retail & Markets Association (Great Britain) , who acquired the Group's primary care business in Spain in October 2005. This activity, presented as "discontinued operations" as from 1 January 2005, will be undertaken until early 2007. For the first half of 2006, net profit was not significant and amounted to EUR 0.7 million for the same period a year ago.

--Consolidated profit

As a result of the items noted above, consolidated profit declined by 1.2% to EUR 88.5 million (EUR 88.1 million attributable to equity holders of Ipsen S.A.) in the first half of 2006, against EUR 89.6 million (EUR 89.4 million attributable to equity holders of Ipsen S.A.) a year earlier. Consolidated profit represented 18.5% of revenues for the half-year to 30 June 2006, compared with 19.9% a year earlier.

--Milestones received in cash during the period but not yet recognised as revenues in the Group's income statement

For the half-year ended 30 June 2006, the total milestones received in cash by the Group but not yet recognised as revenues in its consolidated income statement amounted to EUR 94.3 million, against EUR 5.0 million for the half-year to 30 June 2005. These payments will be recognized in the Group's income statement as revenues going forward as follows :
(in EUR million)                      Milestones received in cash but
                                            not yet recognized as
                                        revenues for the half-year
                                               periods ended :
------------------------------------- --------------------------------
                                        June 30, 2006    June 30, 2005
------------------------------------- ------------------ -------------
Total
These will be recognized as revenues
 in the future as follows:                         94.3           5.0
------------------------------------- ------------------ -------------
In the second  half  of 2006                        4.0           2.4
In 2007                                             8.0           1.1
In 2008 and beyond                                 82.3           1.5
------------------------------------- ------------------ -------------


After 30 June 2006, other milestones have been received in cash for a total of EUR 73.6 million in the context of Roche's opt-in To purposefully accept some situation or condition ahead of time. For example, to opt-in to an e-mail campaign means that you want to receive periodic newsletters or information, which may include advertising from the publisher or third parties.  for BIM 51077, as well as an additional payment by Medicis within the framework of the Reloxin(R) distribution agreement for the United States, Canada and Japan. In the future, these additional payments will be recognized as revenues in the Group's accounts as follows: EUR 2.6 million in the second half of 2006, EUR 5.5 million in 2007, and EUR 65.5 million in 2008 and beyond. These amounts are additional to the amounts shown in the table above.

2 - CASH FLOW AND CAPITAL FOR THE HALF-YEARS ENDED 30 JUNE 2006 AND 30 JUNE 2005

The consolidated cash flow statement shows a net increase in cash flow of EUR 24.2 million for the first half of 2006, before currency impact, compared to a decrease of EUR 55.6 million for the same period a year ago.

In the first half of 2006, the Group generated a strong EUR 130.2 million cash flow from operating activities, against EUR 62.5 million a year earlier. The cash position as at 30 June 2006 benefited from sustained activity during the period as well as from the payment of a EUR 75.5 million (USD90.1 million) milestone by Medicis under the Reloxin(R) distribution licence granted by the Group for the United States, Canada and Japan in the aesthetics indication. Under that same contract, the Group also received from Medicis during the first half of 2006 a down payment of EUR 10 million on the extra payment of USD35 million due from Medicis after the end of negotiations on a potential extension of its distribution activities in Europe. As a result, the Group has reimbursed most of its credit facilities, while keeping open the option of re-using them (for a total of EUR 241.2 million as of 30 June 2006). The Group utilised EUR 25.2 million for its investment transactions and paid out EUR 50.4 million in dividends during the half-year to 30 June 2006. Cash derived de·rive  
v. de·rived, de·riv·ing, de·rives

v.tr.
1. To obtain or receive from a source.

2.
 from discontinued dis·con·tin·ue  
v. dis·con·tin·ued, dis·con·tin·u·ing, dis·con·tin·ues

v.tr.
1. To stop doing or providing (something); end or abandon:
 activities amounted to EUR 1.6 million for the period (half-year to 30 June 2005 : nil).

ANALYSIS OF THE CASH FLOW STATEMENTS FOR THE HALF-YEARS TO 30 JUNE 2006 AND 30 JUNE 2005
30 June    30 June
                                                    2006       2005
(in thousands of euros)                                     pro forma
------------------------------------------------ ---------- ----------
   - Cash flow before variation in working
    capital requirements                            89,558     98,302
   - (Increase) decrease in working capital
    requirements for operations                     40,616    (35,775)
-- Net cash flow generated by operating
 activities                                        130,174     62,527
-- Net cash flow used in investment activities     (25,204)   (29,741)
-- Net cash flow used in financing activities      (82,358)   (88,416)
-- Net cash flow provided by discontinued
 activities                                          1,604          -
Increase (decrease) in cash flow for the half-
 year                                               24,216    (55,630)
Cash and cash equivalents at beginning of year     200,564     92,763
Impact of pro forma treatment                            -     (5,583)
Impact of foreign exchange variations                  (17)       192
------------------------------------------------ ---------- ----------
Cash and cash equivalents at end of half-year      224,763     31,742
------------------------------------------------ ---------- ----------


Net cash flow generated by operating activities

During the first half of 2006, cash flow before changes in working capital totalled EUR 89.6 million against EUR 98.3 million for the same period a year ago. This reflects an increase in deferred tax assets mainly due to the deferred tax asset recognized on the milestone of USD90.1 million received from Medicis.

Working capital requirements Capital requirements

Financing required for the operation of a business, composed of long-term and working capital plus fixed assets.
 for operating activities declined EUR 40.6 million for the first half of 2006 against an increase of EUR 35.8 million a year ago. This evolution is linked to the following :

--The balance between current assets Current Assets

Appearing on a company's balance sheet, it represents cash, accounts receivable, inventory, marketable securities, prepaid expenses, and other assets that can be converted to cash within one year.
 and current liabilities Current Liabilities

Usually appearing on a company's balance sheet, it represents the amount owed for interest, accounts payable, short-term loans, expenses incurred but unpaid, and other debts due within one year.
 represents a debt which increased by EUR 58.4 million during the first half of 2006. This increase resulted notably from the collection of payments received from Medicis out of which EUR 83.8 million had not yet been recognised as revenues as at 30 June 2006. This impact has been partially offset by the decrease of other assets other assets

Assets of relatively small value. For financial reporting purposes, firms frequently combine small assets into a single category rather than listing each item separately.
 and liabilities (linked in particular to partnerships and insurance premiums).

--An increase in inventories of EUR 3.4 million and in trade receivables Receivables

An asset designation applicable to all debts, unsettled transactions or other monetary obligations owed to a company by its debtors or customers. Receivables are recorded by a company's accountants and reported on the balance sheet, and they and include all debts owed
 of EUR 30.4 million, mainly resulting from business growth and from the modification A change or alteration in existing materials.

Modification generally has the same meaning in the law as it does in common parlance. The term has special significance in the law of contracts and the law of sales.
 of the payment terms of certain customers in France, were added to the decrease in trade payables Payables

Related: Accounts payable
 of EUR 18.1 million, partly due to the payment during the period of IPO-related fees accrued ac·crue  
v. ac·crued, ac·cru·ing, ac·crues

v.intr.
1. To come to one as a gain, addition, or increment: interest accruing in my savings account.

2.
 in 2005 and to an invoicing in·voice  
n.
1. A detailed list of goods shipped or services rendered, with an account of all costs; an itemized bill.

2. The goods or services itemized in an invoice.

tr.v.
 level from suppliers which was lower than in the fourth quarter of 2005.

--Conversely, tax payable increased by EUR 34.1 million, comprising EUR 12.6 million for the taxation resulting from the Medicis payment and EUR 16.7 million in respect of the balance of tax payable related to Group affiliates in France for the first half of 2006.

As a result of the above, net cash flow generated by operating activities amounted to EUR 130.2 million for the first half of 2006 against EUR 62.5 million a year ago.

Net cash flow used in investment activities

Net cash flow used in investment activities amounted to EUR 25.2 million for the first half of 2006 (first half of 2005, EUR 29.7 million). This comprised mainly fixed asset acquisitions, net of disposals, of EUR 14.4 million, against EUR 15.3 million a year ago, as well as a EUR 7.0 million increase in working capital requirements linked to investment activities for the period, compared with an increase of EUR 14.6 million a year ago. Additionally, the Group utilised EUR 2.1 million in the first half of 2006 to fund its liquidity contract on Ipsen shares.

During the first half of 2006, tangible Possessing a physical form that can be touched or felt.

Tangible refers to that which can be seen, weighed, measured, or apprehended by the senses. A tangible object is something that is real and substantial. An automobile is an example of tangible Personal Property.
 fixed asset acquisitions totalled EUR 14.2 million, mostly consisting of capital expenditure required to maintain the Group's industrial facilities, namely EUR 3.6 million for industrial buildings and fittings fit·ting  
adj.
Being in keeping with a situation; appropriate.

n.
1. The act of trying on clothes whose fit is being adjusted.

2. A small detachable part for a machine or apparatus.

3.
 and EUR 4.7 million for machinery, mainly at the Dreux Dreux (drö), town (1990 pop. 35,866), Eure-et-Loir dept., N central France. It is an industrial center where foundry products, boilers, metal products, radio and television equipment, and chemicals are manufactured.  and Wrexham Wrexham (rĕk`səm), Welsh Wrescam, town (1981 pop. 39,929) and county borough, 193 sq mi (499 sq km), NE Wales. It lies in the coal field of N Wales.  production sites.

The increase of EUR 7.0 million for working capital in investing activities during the first half of 2006 is mostly due to the payment during the period of liabilities recorded in 2005 in France.

Net cash flow used in financing activities

In the half-year to 30 June 2006, net cash flow used in financing activities totalled EUR 82.4 million against EUR 88.4 million a year ago. Following payments received from Medicis, EUR 31.1 million of the Group's credit facilities has been repaid, thus reducing the overdraft A check that is drawn on an account containing less money than the amount stated on the check.

The term overdraft is also used in reference to the condition that exists when vouchers 
 as at 30 June 2006 to EUR 6.6 million. In the half-year to 30 June 2005, repayment Repayment

The act of paying back a debt.

Notes:
Everyone has to repay their debts eventually.
See also: Debt, Defeasance, Loan
 of credit facilities amounted to EUR 70.0 million. The Group still has the option to utilise fully these credit facilities.

In the first half of 2006, the Group paid out EUR 50.4 million in dividends, compared with EUR 29.3 million in the same period of 2005.

Net cash flow from discontinued activities

In the half-year to 30 June 2006, net cash flow from discontinued activities amounted to EUR 1.6 million (half-year to 30 June 2005: nil), resulting from the decrease in working capital requirements linked to primary care activities in Spain, which were divested in October 2005.

ANALYSIS OF NET CASH

At 30 June 2006, the Group's net cash(1) was EUR 193.3 million, compared with EUR 138.3 million net cash as at 31 December 2005. The Group has four-year credit facilities totalling EUR 241.2 million, out of which only EUR 6.6 million was in use at 30 June 2006, compared with a EUR 37.8 million utilisation as at 31 December 2005. The covenants included in the loan agreements, namely net debt to equity and net debt to EBITDA (Earnings Before Interest, Taxes, Depreciation and Amortization) A metric used to show a company's profitability, but not its cash flow. EBITDA became popular in the 1980s to show the potential profitability of leveraged buyouts, but has become (2), are irrelevant Unrelated or inapplicable to the matter in issue.

Irrelevant evidence has no tendency to prove or disprove any contested fact in a lawsuit.


irrelevant adj.
 in respect of the current positive net cash situation.

3 - SHAREHOLDING STRUCTURE

On the basis of available information, Ipsen believes that its shareholding structure as at 30 June 2006 breaks down as follows.

On an outstanding basis:
Shares held      In %
----------------------------------------------------------- ----------
Mayroy                                          62,162,828       74.0%
Board members                                       14,345        0.0%
Employees                                        1,076,830        1.3%
Treasury shares                                     14,791        0.0%
Public                                          20,755,889       24.7%
----------------------------------------------------------- ----------
Total                                           84,024,683      100.0%
----------------------------------------------------------- ----------


On the same basis, after full exercise of stock options and bonus shares, Ipsen's shareholding structure would break down as follows:
Shares held      In %
------------------------------------------- --------------- ----------
Mayroy                                          60,506,884       71.7%
Board members                                       14,345        0.0%
Employees                                        3,082,774        3.7%
Treasury shares                                     14,791        0.0%
Public                                          20,755,889       24.6%
------------------------------------------- --------------- ----------
Total                                           84,374,683      100.0%
------------------------------------------- --------------- ----------


(1) Net cash: cash and cash equivalents minus bank overdrafts, bank borrowings and other financial liabilities plus or minus derivative derivative: see calculus.
derivative

In mathematics, a fundamental concept of differential calculus representing the instantaneous rate of change of a function.
 financial instruments

(2) EBITDA: Earnings before interest, tax, depreciation and amortisation Noun 1. amortisation - the reduction of the value of an asset by prorating its cost over a period of years
amortization

reduction, step-down, diminution, decrease - the act of decreasing or reducing something

2.
 
ANNEX 1

                 RESUME CONSOLIDATED INCOME STATEMENT


                                                   30 June
         (in thousand of euros)          30 June      2005   30 June
                                            2006   Pro forma  2005 (1)
                                                      (1)
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Sales                                     430,607   404,099   385,694
---------------------------------------- --------- --------- ---------
Other revenues                             46,569    45,684    39,992
---------------------------------------- --------- --------- ---------
Total Revenues                            477,176   449,783   425,686
---------------------------------------- --------- --------- ---------
Cost of goods sold                        (88,879)  (84,437)  (90,227)
---------------------------------------- --------- --------- ---------
Research and Development expenses         (83,817)  (75,565)  (74,110)
---------------------------------------- --------- --------- ---------
Selling expenses                         (150,608) (141,494) (138,627)
---------------------------------------- --------- --------- ---------
General and administrative expenses       (37,392)  (32,672)  (30,682)
---------------------------------------- --------- --------- ---------
Other operating income and expenses        (8,298)      174     1,919
---------------------------------------- --------- --------- ---------
Restructuring cost                            189         -         -
---------------------------------------- --------- --------- ---------
Impairment losses                               -         -         -
---------------------------------------- --------- --------- ---------
Operating income                          108,371   115,789    93,959
---------------------------------------- --------- --------- ---------
- Cash ans cash equivalent                  2,767     1,089       450
---------------------------------------- --------- --------- ---------
- Cost of financial debt                   (1,208)   (4,378)   (4,211)
---------------------------------------- --------- --------- ---------
Net cost of financial debt                  1,559    (3,289)   (3,761)
---------------------------------------- --------- --------- ---------
Other financial income and expenses        (1,202)   (1,348)   (1,007)
---------------------------------------- --------- --------- ---------
Income taxes                              (20,280)  (22,256)  (20,400)
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Net profit continuing operations           88,448    88,896    68,791
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Discontinued operations (1)                    33       683       683
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Net profit from continuing operation       88,481    89,579    69,474
---------------------------------------- --------- --------- ---------
- attributable to equity holders of the
 parent                                    88,144    89,368    62,075
---------------------------------------- --------- --------- ---------
- minority interest                           337       211     7,399
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Basic earnings per share, continuing
 operations (in euros)                      1.049     1.183     1.048
---------------------------------------- --------- --------- ---------
Diluted earnings per share, continuing
 operations (in euros)                      1.049     1.183     1.048
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Basic earnings per share, discontinuing
 operations (in euros)                      0.000     0.009     0.011
---------------------------------------- --------- --------- ---------
Diluted earnings per share,
 discontinuing operations (in euros)        0.000     0.009     0.011
---------------------------------------- --------- --------- ---------

---------------------------------------- --------- --------- ---------
Basic earnings per share (in euros)         1.049     1.192     1.059
---------------------------------------- --------- --------- ---------
Diluted earnings per share (in euros)       1.049     1.192     1.059
---------------------------------------- --------- --------- ---------


(1) In accordance with IFRS 5, the 2005 income statement has been restated to provide comparable data for the periods presented

ANNEX an·nex  
tr.v. an·nexed, an·nex·ing, an·nex·es
1. To append or attach, especially to a larger or more significant thing.

2.
 2

RESUME CONSOLIDATED BALANCE SHEET consolidated balance sheet

A balance sheet in which assets and liabilities of a parent company and its controlled subsidiaries are combined, thereby presenting balance sheet items for the parent and its subsidiaries as if they were a single firm.
 
30 June      31
             (in thousand of euros)                  2006     December
                                                                2005
------------------------------------------------- ---------- ---------
ASSET
------------------------------------------------- ---------- ---------
Goodwills                                           188,836   188,836
------------------------------------------------- ---------- ---------
Other intangible assets, net                         38,949    39,800
------------------------------------------------- ---------- ---------
Property, plant and equipment, at cost              186,058   187,769
------------------------------------------------- ---------- ---------
Equity investments                                    2,260     2,656
------------------------------------------------- ---------- ---------
Other non-current assets                              4,485     2,671
------------------------------------------------- ---------- ---------
Non-current financial assets                          6,745     5,327
------------------------------------------------- ---------- ---------
Deferred tax assets                                  48,621    13,096
------------------------------------------------- ---------- ---------
Total non-current assets                            469,209   434,828
------------------------------------------------- ---------- ---------
Inventories                                          77,738    74,390
------------------------------------------------- ---------- ---------
Trade receivables                                   194,371   164,681
------------------------------------------------- ---------- ---------
Current tax assets                                    1,532    10,951
------------------------------------------------- ---------- ---------
Other current assets                                 56,253    42,966
------------------------------------------------- ---------- ---------
cash and cash equivalent                            226,155   202,034
------------------------------------------------- ---------- ---------
Total current assets                                556,049   495,022
------------------------------------------------- ---------- ---------
Non current assets classified as held for sale        6,052    12,659
------------------------------------------------- ---------- ---------
TOTAL ASSETS                                      1,031,310   942,509
------------------------------------------------- ---------- ---------

SHAREHOLDER'S EQUITY AND LIABILITIES
------------------------------------------------- ---------- ---------
Share capital                                        84,025    84,025
------------------------------------------------- ---------- ---------
Share premiums and consolidated reserves            505,702   420,591
------------------------------------------------- ---------- ---------
Profit of the Year                                   88,144   119,230
------------------------------------------------- ---------- ---------
Cumulative translation reserve                       (5,176)   (4,080)
------------------------------------------------- ---------- ---------
Shareholders' equity attributable to equity
 holder of the parent                               672,695   619,766
------------------------------------------------- ---------- ---------
Minority interest                                     1,478     1,334
------------------------------------------------- ---------- ---------
Total Shareholders' equity                          674,173   621,100
------------------------------------------------- ---------- ---------
Retirement benefit obligations                        8,335     8,032
------------------------------------------------- ---------- ---------
Long-term provisions                                  9,599     8,266
------------------------------------------------- ---------- ---------
Bank loans                                            6,621    37,751
------------------------------------------------- ---------- ---------
Other financial liabilities                          16,245    15,508
------------------------------------------------- ---------- ---------
Deferred tax liabilities                              1,604     1,358
------------------------------------------------- ---------- ---------
Other non-current liabilities                        87,079         -
------------------------------------------------- ---------- ---------
Total non-current equivalent                        129,483    70,915
------------------------------------------------- ---------- ---------
Short-term provisions                                 3,138     3,309
------------------------------------------------- ---------- ---------
Bank loans                                            6,350     7,074
------------------------------------------------- ---------- ---------
Financial liabilities                                 2,286     1,760
------------------------------------------------- ---------- ---------
Trade payables                                       88,641   107,045
------------------------------------------------- ---------- ---------
Current tax liabilities                              26,916     2,223
------------------------------------------------- ---------- ---------
Other current liabilities                            89,522   113,525
------------------------------------------------- ---------- ---------
Bank overdrafts                                       1,392     1,470
------------------------------------------------- ---------- ---------
Total current liabilities                           218,245   236,406
------------------------------------------------- ---------- ---------
Liabilities directly associated with non-current
 assets classified as held for sale                   9,409    14,088
------------------------------------------------- ---------- ---------

TOTAL SHAREHOLDERS' EQUITY AND LIABILITIES        1,031,310   942,509
------------------------------------------------- ---------- ---------

                                ANNEX 3

              RESUME CONSOLIDATED STATEMENT OF CASH FLOW

                                                   30 June
                                          30 June    2005   30June2005
           (in thousand of 'euros)          2006     Pro       (1)
                                                    forma
                                                      (1)
----------------------------------------- -------- -------- ----------
Profit for the period                      88,481   89,579     69,474
----------------------------------------- -------- -------- ----------
Profit  from discontinued operations          (33)
----------------------------------------- -------- -------- ----------
Profit from continuing operations          88,448
----------------------------------------- -------- -------- ----------
Non-cash and non-operating items :                       -          -
----------------------------------------- -------- -------- ----------
- Depreciation, amortization and
 impairment losses                         19,068   14,167     12,433
----------------------------------------- -------- -------- ----------
- Increase/(decrease) in faire value of
 Financial Instruments                       (264)     436        436
----------------------------------------- -------- -------- ----------
- impairment of goodwill                        -        -          -
----------------------------------------- -------- -------- ----------
- Net gains or losses on disposal of non-
 current assets                              (139)      31         14
----------------------------------------- -------- -------- ----------
- Share of investment grant included in
 profit and loss                              (60)     (54)         -
----------------------------------------- -------- -------- ----------
- Exchange difference                         565     (224)      (589)
----------------------------------------- -------- -------- ----------
- Change in deferred taxes                (20,090)  (6,902)    (6,994)
----------------------------------------- -------- -------- ----------
- Cost of stock options                     1,994    1,269      1,269
----------------------------------------- -------- -------- ----------
- Profit/Loss coming down from own
 capital shares disposal                       29        -          -
----------------------------------------- -------- -------- ----------
- Other transactions of a non-cash nature       7        -          -
----------------------------------------- -------- -------- ----------
cash flow from operating activities
 before changes in working capital         89,558   98,302     76,043
----------------------------------------- -------- -------- ----------
- (Increase) / decrease in inventories     (3,378)  (3,810)    (6,595)
----------------------------------------- -------- -------- ----------
- (Increase) / decrease in tradre
 receivables                              (30,361) (14,598)   (11,786)
----------------------------------------- -------- -------- ----------
- (Decrease) / increase  in trade
 payables                                 (18,115) (10,374)   (11,516)
----------------------------------------- -------- -------- ----------
- net change in income tax liability       34,077    2,563      1,316
----------------------------------------- -------- -------- ----------
- Net change in other operating assets
 and liabilities                           58,393   (9,556)    (7,096)
----------------------------------------- -------- -------- ----------
Variation du besoin en fonds de roulement
 lie a l'activite                          40,616  (35,775)   (35,677)
----------------------------------------- -------- -------- ----------
NET CASH PROVIDED BY OPERATING ACTIVITIES 130,174   62,527     40,366
----------------------------------------- -------- -------- ----------
Acquisition  of property, plant &
 equipment                                (14,202) (13,482)   (12,720)
----------------------------------------- -------- -------- ----------
Acquisitions of intangible assets          (1,473)  (2,351)    (1,318)
----------------------------------------- -------- -------- ----------
Payments to post-employment benefit plans  (1,085)       -          -
----------------------------------------- -------- -------- ----------
Proceeds from disposal of intangible
 assets and property, plant and equipment   1,295      503        475
----------------------------------------- -------- -------- ----------
Acquisition of investments in non-
 consolidated companies                       (40)       -          -
----------------------------------------- -------- -------- ----------
Own capital shares                           (385)       -          -
----------------------------------------- -------- -------- ----------
Impact of changes in the scope of
 consolidation                                  -        -    (51,650)
----------------------------------------- -------- -------- ----------
Other cash-flow related to investing
 activities                                (2,301)     178        129
----------------------------------------- -------- -------- ----------
Change in working capital related to
 investing activities                      (7,013) (14,589)   (13,743)
----------------------------------------- -------- -------- ----------
NET CASH USED IN INVESTING ACTIVITIES     (25,204) (29,741)   (78,827)
----------------------------------------- -------- -------- ----------
Additional long-term borrowings                 -   11,714     11,712
----------------------------------------- -------- -------- ----------
Repayment of long-term borrowings         (31,083) (70,015)   (80,995)
----------------------------------------- -------- -------- ----------
Net change in short-term borrowings          (724)    (648)      (648)
----------------------------------------- -------- -------- ----------
Capital increase                                -        -    124,528
----------------------------------------- -------- -------- ----------
Increase of share premiums                      -        -     29,478
----------------------------------------- -------- -------- ----------
Dividends paid by Ipsen S.A.              (50,407) (29,303)   (29,303)
----------------------------------------- -------- -------- ----------
Dividends paid by subsidiaries to
 minority interest                           (158)     (24)       (24)
----------------------------------------- -------- -------- ----------
Change of working capital related to
 financing activities                          14     (140)    (2,427)
----------------------------------------- -------- -------- ----------
NET CASH PROVIDED/(USED) IN FINANCING
 ACTIVITIES                               (82,358) (88,416)    52,321
----------------------------------------- -------- -------- ----------
Reported change in cash and cash
 equivalent                                 1,604        -          -
----------------------------------------- -------- -------- ----------
THEORETICAL CHANGE IN CASH AND CASH
 EQUIVALENT                                24,216  (55,630)    13,860
----------------------------------------- -------- -------- ----------
Impact of pro forma restatements                -   (5,583)         -
----------------------------------------- -------- -------- ----------
CHANGE IN CASH AND CASH EQUIVALENTS        24,216  (61,213)    13,860
----------------------------------------- -------- -------- ----------

----------------------------------------- -------- -------- ----------
CASH AND CASH EQUIVALENT AT THE BEGINNING
 OF THE YEAR                              200,564   92,763     17,742
----------------------------------------- -------- -------- ----------
lmpact of exchange rate fluctuations          (17)     192        140
----------------------------------------- -------- -------- ----------
Cash and cash equivalent at the end of
 the year                                 224,763   31,742     31,742
----------------------------------------- -------- -------- ----------


(1) According to IFRS 5, since the Balance sheet as at 30 June 2005 has not been adjusted, the consolidated statement of cash flow at 30 June 2005 has not been adjusted either.
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