Insulin resistance and pre-diabetes.
National Diabetes Information Clearinghouse The National Diabetes Information Clearinghouse(NDIC) is an information dissemination service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health, which is part of the U.S.
Insulin resistance Insulin Resistance Definition
Insulin resistance is not a disease as such but rather a state or condition in which a person's body tissues have a lowered level of response to insulin, a hormone secreted by the pancreas that helps to regulate the level is a silent condition that increases the chances of developing diabetes and heart disease. Learning about insulin resistance is the first step you can take toward making lifestyle changes that will help you prevent diabetes and other health problems.
What does insulin do?
After you eat, the food is broken down into glucose, the simple sugar that is the main source of energy for the body's cells. But your cells cannot use glucose without insulin, a hormone produced by the pancreas. Insulin helps the cells take in glucose and convert it to energy. When the pancreas does not make enough insulin or the body is unable to use the insulin that is present, the cells cannot use glucose. Excess glucose builds up in the bloodstream, setting the stage for diabetes.
Being obese or overweight affects the way insulin works in your body. Extra fat tissue can make your body resistant to the action of insulin, but exercise helps insulin work well.
How are insulin resistance, pre-diabetes, and type 2 diabetes type 2 diabetes
See diabetes mellitus. linked?
If you have insulin resistance, your muscle, fat, and liver cells do not use insulin properly. The pancreas tries to keep up with the demand for insulin by producing more. Eventually, the pancreas cannot keep up with the body's need for insulin, and excess glucose builds up in the bloodstream. Many people with insulin resistance have high levels of blood glucose blood glucose Diabetology The principal sugar produced by the body from food–especially carbohydrates, but also from proteins and fats; glucose is the body's major source of energy, is transported to cells via the circulation and used by cells in the presence and high levels of insulin circulating in their blood at the same time.
People with blood glucose levels blood glucose level,
n level of glu-cose in the bloodstream, normally about 70 to 115 mg/dL after fasting overnight. Higher levels may indicate diseases such as diabetes mellitus. that are higher than normal but not yet in the diabetic range have "pre-diabetes." Doctors sometimes call this condition impaired fasting glucose fasting glucose Fasting blood sugar, fasting plasma glucose Endocrinology Glucose obtained from a Pt who has had nothing–except water by mouth for 8+ hrs; FG is used in evaluating Pts for possible DM Ref range 65-115 mg/dL non-diabetic; 110-140 mg/dL, or impaired glucose tolerance Impaired Glucose Tolerance (IGT) is a pre-diabetic state of dysglycemia, that is associated with insulin resistance and increased risk of cardiovascular pathology. IGT may precede type 2 diabetes mellitus by many years. IGT is also a risk factor for mortality. , depending on the test used to diagnose it. About 16 million people in the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. have pre-diabetes and most don't know Don't know (DK, DKed)
"Don't know the trade." A Street expression used whenever one party lacks knowledge of a trade or receives conflicting instructions from the other party. it.
If you have pre-diabetes, you have a higher risk of developing type 2 diabetes, formerly called adult-onset diabetes or noninsulin-dependent diabetes. Studies have shown that most people with pre-diabetes go on to develop type 2 diabetes within 10 years, unless they lose 5 to 7 percent of their body weight--which is about 10 to 15 pounds for someone who weighs 200 pounds--by making modest changes in their diet and level of physical activity. People with pre-diabetes also have a higher risk of heart disease.
Type 2 diabetes is sometimes defined as the form of diabetes that develops when the body does not respond properly to insulin, as opposed to type 1 diabetes type 1 diabetes
See diabetes mellitus. , in which the pancreas makes no insulin at all. At first, the pancreas keeps up with the added demand by producing more insulin. In time, however, it loses the ability to secrete secrete /se·crete/ (se-kret´) to elaborate and release a secretion.
To generate and separate a substance from cells or bodily fluids. enough insulin in response to meals.
Insulin resistance can also occur in people who have type 1 diabetes, especially if they are overweight.
What causes insulin resistance?
Because insulin resistance tends to run in families, we know that genes are partly responsible. Excess weight also contributes to insulin resistance because too much fat interferes with muscles' ability to use insulin. Lack of exercise further reduces muscles' ability to use insulin.
Many people with insulin resistance and high blood glucose have excess weight around the waist, high LDL LDL - ["LDL: A Logic-Based Data-Language", S. Tsur et al, Proc VLDB 1986, Kyoto Japan, Aug 1986, pp.33-41]. (bad) blood cholesterol levels, low HDL (Hardware Description Language) A language used to describe the functions of an electronic circuit for documentation, simulation or logic synthesis (or all three). Although many proprietary HDLs have been developed, Verilog and VHDL are the major standards. (good) cholesterol levels, high levels of triglycerides Triglycerides
Fatty compounds synthesized from carbohydrates during the process of digestion and stored in the body's adipose (fat) tissues. High levels of triglycerides in the blood are associated with insulin resistance. (another fat in the blood), and high blood pressure, all conditions that also put the heart at risk. This combination of problems is referred to as the metabolic syndrome metabolic syndrome
See syndrome X.
A group of risk factors for heart disease, diabetes, and stroke. , or the insulin resistance syndrome (formerly called Syndrome X syndrome X
A cluster of metabolic abnormalities, including insulin resistance, high blood levels of triglycerides, low blood levels of HDL-cholesterol, and obesity, that increase the risk of chronic diseases such as hypertension, coronary artery ).
What are the symptoms of insulin resistance and pre-diabetes?
Insulin resistance and pre-diabetes usually have no symptoms. You may have one or both conditions for several years without noticing anything. If you have a severe form of insulin resistance, you may get dark patches of skin, usually on the back of your neck. Sometimes people get a dark ring around their neck. Other possible sites for these dark patches include elbows, knees, knuckles, and armpits. This condition is called acanthosis nigricans acanthosis ni·gri·cans
An eruption of velvety wartlike growths accompanied by hyperpigmentation in the skin of the armpits, neck, anogenital area, and groin, occurring in a benign form in children, but associated with internal malignancy or .
If you have a mild or moderate form of insulin resistance, blood tests may show normal or high blood glucose and high levels of insulin at the same time.
Do you have insulin resistance or pre-diabetes?
If you are overweight and age 45 or older, you should ask your doctor about having one of the standard blood glucose tests that detect pre-diabetes and type 2 diabetes. If you are younger than 45 and overweight, your doctor may want to test your blood glucose, especially if you have one or more of the following risk factors:
* family history of diabetes
* low HDL cholesterol HDL cholesterol
See high-density lipoprotein.
About one-third or one-fourth of all cholesterol is high-density lipoprotein cholesterol. and high triglycerides
* high blood pressure
* history of gestational diabetes Gestational Diabetes Definition
Gestational diabetes is a condition that occurs during pregnancy. Like other forms of diabetes, gestational diabetes involves a defect in the way the body processes and uses sugars (glucose) in the diet. (diabetes during pregnancy) or gave birth to a baby weighing more than 9 pounds
* minority group background (African American African American Multiculture A person having origins in any of the black racial groups of Africa. See Race. , American Indian, Hispanic American/Latino, or Asian American/ Pacific Islander)
Diabetes and pre-diabetes can be detected with one of the following tests:
A fasting glucose test measures your blood glucose after you have gone overnight without eating. This test is most reliable when done in the morning. Fasting glucose levels of 110 to 125 mg/dL are above normal but not high enough to be called diabetes. This condition is called pre-diabetes or impaired fasting glucose (IFG IFG Impaired Fasting Glucose
IFG International Forum on Globalization
IFG Individual and Family Grant
IFG Inferior Frontal Gyrus
IFG Inter-Frame Gap
IFG I Feel Good
IFG International Facilities Group (Northbrook, Illinois) ), and it suggests that you have probably had insulin resistance for some time. IFG is considered a pre-diabetic state, meaning that you are more likely to develop diabetes but do not have it yet.
A glucose tolerance test glucose tolerance test
A test for evaluating the body's capability to metabolize glucose and based upon the ability of the liver to absorb and store excess glucose as glycogen. measures your blood glucose after an overnight fast and 2 hours after you drink a sweet liquid provided by the doctor or laboratory. If your blood glucose falls between 140 and 199 mg/dL 2 hours after drinking the liquid, your glucose tolerance is above normal but not high enough for diabetes. This condition, also a form of pre-diabetes, is called impaired glucose tolerance (IGT IGT impaired glucose tolerance. ) and, like IFG, it points toward a history of insulin resistance and a risk for developing diabetes.
These tests give only indirect evidence of insulin resistance. The test that most accurately measures insulin resistance is too complicated and expensive to use as a screening tool in most doctors' offices. The test, called the euglycemic clamp, is a research tool that helps scientists learn more about sugar metabolism problems. Insulin resistance can also be assessed with measurement of fasting insulin. If conventional tests show that you have IFG or IGT, your doctor may suggest changes in diet and exercise to reduce your risk of developing diabetes.
Can you reverse insulin resistance?
Yes. Physical activity and weight loss make the body respond better to insulin. By losing weight and being more physically active, you may avoid developing type 2 diabetes. In fact, a major study has verified the benefits of healthy lifestyle changes and weight loss. In 2001, the National Institutes of Health completed the Diabetes Prevention Program (DPP DPP - Dining Philosophers Problem ), a clinical trial designed to find the most effective ways of preventing type 2 diabetes in overweight people with pre-diabetes. The researchers found that lifestyle changes reduced the risk of diabetes by 58 percent. Also, many people with pre-diabetes returned to normal blood glucose levels.
The main goal in treating insulin resistance and pre-diabetes is to help your body relearn Verb 1. relearn - learn something again, as after having forgotten or neglected it; "After the accident, he could not walk for months and had to relearn how to walk down stairs" to use insulin normally. You can do several things to help reach this goal.
Be Active and Eat Well
Physical activity helps your muscle cells use blood glucose because they need it for energy. Exercise makes those cells more sensitive to insulin.
The DPP confirmed that people who follow a low-fat, low-calorie diet and who increase activities such as walking briskly or riding a bike for 30 minutes, five times a week, have a far smaller risk of developing diabetes than people who do not exercise regularly. The DPP also reinforced the importance of a low-calorie, low-fat diet low-fat diet A diet low in fats, especially saturated fats, which has a positive effect on arthritis, CA, ASHD, DM, HTN, obesity, and strokes. See Diet, Low-fat snack; Cf Animal fat, High-fat diet. . Following a low-calorie, low-fat diet can provide two benefits. If you are overweight, one benefit is that limiting your calorie and fat intake can help you lose weight. DPP participants who lost weight were far less likely to develop diabetes than others in the study who remained at an unhealthy weight. Increasing your activity and following a low-calorie, low-fat diet can also improve your blood pressure and cholesterol levels and has many other health benefits.
Scientists have established some numbers to help people set goals that will reduce their risk of developing glucose metabolism glucose metabolism,
n the process by which simple sugars found in many foods are processed and used to produce energy in the form of ATP. Once consumed, glucose is absorbed by the intestines and into the blood. problems.
* Weight. Body mass index (BMI BMI body mass index.
body mass index
Body mass index (BMI)
A measurement that has replaced weight as the preferred determinant of obesity. ) is a measure used to evaluate body weight relative to height. You can use BMI to find out whether you are underweight Underweight
An situation where a portfolio does not hold a sufficient amount of securities to satisfy the accepted benchmark of the portfolio's asset allocation strategy.
Notes: , normal weight, overweight, or obese. Use the table on page 5 to find your BMI.
--Find your height in the left-hand column.
--Move across in the same row to the number closest to your weight.
--The number at the top of that column is your BMI. Check the word above your BMI to see whether you are normal weight, overweight, or obese. If you are overweight or obese, talk with your doctor about ways to lose weight to reduce your risk of diabetes.
* Blood pressure. Blood pressure is expressed as two numbers that represent pressure in your blood vessels Blood vessels
Tubular channels for blood transport, of which there are three principal types: arteries, capillaries, and veins. Only the larger arteries and veins in the body bear distinct names. when your heart is beating (systolic pressure systolic pressure
The highest arterial blood pressure reached during any given ventricular cycle. ) and when it is resting (diastolic pressure diastolic pressure
The lowest arterial blood pressure reached during any given ventricular cycle. ). The numbers are usually written with a slash--for example, 140/90, which is expressed as "140 over 90." For the general population, blood pressure below 130/85 is considered normal, although people whose blood pressure is slightly elevated and who have no additional risk factors for heart disease may be advised to make lifestyle changes--that is, diet and exercise--rather than take blood pressure medicines. People who have diabetes, however, should take whatever steps necessary, including lifestyle changes and medicine, to reach a blood pressure goal of below 130/80.
* Cholesterol. Your cholesterol is usually reported with three values: low density lipoprotein Low density lipoprotein (LDL)
A fraction of total serum lipids, the so called "bad" cholesterol.
Mentioned in: Hypercholesterolemia (LDL) cholesterol, high Cholesterol, High Definition
Cholesterol is a fatty substance found in animal tissue and is an important component to the human body. It is manufactured in the liver and carried throughout the body in the bloodstream. density lipoprotein lipoprotein (lĭp'əprō`tēn), any organic compound that is composed of both protein and the various fatty substances classed as lipids, including fatty acids and steroids such as cholesterol. (HDL) cholesterol, and total cholesterol. LDL cholesterol LDL cholesterol
See low-density lipoprotein.
Low-density lipoprotein cholesterol is the primary cholesterol molecule. High levels of LDL increase the risk of coronary heart disease. is sometimes called "bad" cholesterol, while HDL cholesterol is called "good" cholesterol. To lower your risk of cardiovascular problems if you have diabetes, you should try to keep your LDL cholesterol below 100 and your total cholesterol below 200.
If you have metabolic syndrome, your doctor may recommend weight loss with diet and exercise, as well as medication to lower your cholesterol and blood pressure levels.
In addition to increasing your risk of cancer and cardiovascular disease Cardiovascular disease
Disease that affects the heart and blood vessels.
Mentioned in: Lipoproteins Test
cardiovascular disease , smoking contributes to insulin resistance. Quitting smoking is not easy, but it could be the single smartest thing you can do to improve your health.
Can medicines help?
Two classes of drugs can improve response to insulin and are used by prescription for type 2 diabetes--biguanides and thiazolidinediones. Other medicines used for diabetes act by other mechanisms. Alphaglucosidase inhibitors restrict or delay the absorption of carbohydrates after eating, resulting in a slower rise of blood glucose levels. Sulfonylureas and meglitinides increase insulin production.
The DPP showed that the diabetes drug metformin metformin /met·for·min/ (met-for´min) an antihyperglycemic agent that potentiates the action of insulin, used in the treatment of type 2 diabetes mellitus.
n. , a biguanide Biguanides (ATC A10 BA) form a class of oral antihyperglycemic drugs used for diabetes mellitus or prediabetes treatment. Examples
Examples of biguanides:
a thiazolidinedione compound that enhances peripheral insulin resistance in the management of diabetes mellitus. , a thiazolidinedione later withdrawn from the market following reports of liver toxicity, delayed or prevented type 2 diabetes in Hispanic women with a history of gestational diabetes. Acarbose acarbose /acar·bose/ (a´kahr-bos) an a inhibitor used in treatment of type 2 diabetes mellitus.
n brand name: Precose, Prandase;
drug class: , an alpha-glucosidase inhibitor, has been effective in delaying development of type 2 diabetes. Additional studies using other diabetes medicines and some types of blood pressure medicines to prevent diabetes are under way. No drug has been approved by the Food and Drug Administration (FDA FDA
Food and Drug Administration
n.pr See Food and Drug Administration.
n.pr the abbreviation for the Food and Drug Administration. ) specifically for insulin resistance or pre-diabetes.
Hope Through Research
Research sponsored by the National Institute of Diabetes and Digestive and Kidney Diseases About NIDDK
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), of the U.S. National Institutes of Health, conducts and supports research on many of the most serious diseases affecting public health. and other components of the Public Health Service has clearly shown that people can do a lot to prevent or delay type 2 diabetes. Volunteers in the DPP were recruited from groups known to be at particularly high risk for type 2 diabetes. About 45 percent of the DPP volunteers were from minority groups known to be at high risk for diabetes. The study was designed to assess the effectiveness of lifestyle changes (weight loss through exercise and diet) and drug therapy (metformin). A control group received a placebo and information on diet and exercise. Participants assigned to intensive lifestyle intervention reduced their risk of getting type 2 diabetes by 58 percent over 3 years. Participants treated with metformin reduced their risk by 31 percent. Metformin is not currently approved for use in preventing diabetes, but the FDA may determine whether to make diabetes prevention an added indication for this drug. In any event, the DPP demonstrated that a healthy diet and exercise are the most effective treatment for insulin resistance and pre-diabetes.
Body Mass Index Table Normal Overweight BMI 19 20 21 22 23 24 25 26 27 Height Body Weight (inches) (pounds) 58 91 96 100 105 110 115 119 124 129 59 94 99 104 109 114 119 124 128 133 60 97 102 107 112 118 123 128 133 138 61 100 106 111 116 122 127 132 137 143 62 104 109 115 120 126 131 136 142 147 63 107 113 118 124 130 135 141 146 152 64 110 116 122 128 134 140 145 151 157 65 114 120 126 132 138 144 150 156 162 66 118 124 130 136 142 148 155 161 167 67 121 127 134 140 146 153 159 166 172 68 125 131 138 144 151 158 164 171 177 69 128 135 142 149 155 162 169 176 182 70 132 139 146 153 160 167 174 181 188 71 136 143 150 157 165 172 179 186 193 72 140 147 154 162 169 177 184 191 199 73 144 151 159 166 174 182 189 197 204 74 148 155 163 171 179 186 194 202 210 75 152 160 168 176 184 192 200 208 216 76 156 164 172 180 189 197 205 213 221 Overweight Obese BMI 28 29 30 31 32 33 34 35 36 Height Body Weight (inches) (pounds) 58 134 138 143 148 153 158 162 167 172 59 138 143 148 153 158 163 168 173 178 60 143 148 153 158 163 168 174 179 184 61 148 153 158 164 169 174 180 185 190 62 153 158 164 169 175 180 186 191 196 63 158 163 169 175 180 186 191 197 203 64 163 169 174 180 186 192 197 204 209 65 168 174 180 186 192 198 204 210 216 66 173 179 186 192 198 204 210 216 223 67 178 185 191 198 204 211 217 223 230 68 184 190 197 203 210 216 223 230 236 69 189 196 203 209 216 223 230 236 243 70 195 202 209 216 222 229 236 243 250 71 200 208 215 222 229 236 243 250 257 72 206 213 221 228 235 242 250 258 265 73 212 219 227 235 242 250 257 265 272 74 218 225 233 241 249 256 264 272 280 75 224 232 240 248 256 264 272 279 287 76 230 238 246 254 263 271 279 287 295 Obese Extreme Obesity BMI 37 38 39 40 41 42 43 44 45 Height Body Weight (inches) (pounds) 58 177 181 186 191 196 201 205 210 215 59 183 188 193 198 203 208 212 217 222 60 189 194 199 204 209 215 220 225 230 61 195 201 206 211 217 222 227 232 238 62 202 207 213 218 224 229 235 240 246 63 208 214 220 225 231 237 242 248 254 64 215 221 227 232 238 244 250 256 262 65 222 228 234 240 246 252 258 264 270 66 229 235 241 247 253 260 266 272 278 67 236 242 249 255 261 268 274 280 287 68 243 249 256 262 269 276 282 289 295 69 250 257 263 270 277 284 291 297 304 70 257 264 271 278 285 292 299 306 313 71 265 272 279 286 293 301 308 315 322 72 272 279 287 294 302 309 316 324 331 73 280 288 295 302 310 318 325 333 340 74 287 295 303 311 319 326 334 342 350 75 295 303 311 319 327 335 343 351 359 76 304 312 320 328 336 344 353 361 369 Extreme Obesity BMI 46 47 48 49 50 51 52 53 54 Height Body Weight (inches) (pounds) 58 220 224 229 234 239 244 248 253 258 59 227 232 237 242 247 252 257 262 267 60 235 240 245 250 255 261 266 271 276 61 243 248 254 259 264 269 275 280 285 62 251 256 262 267 273 278 284 289 295 63 259 265 270 278 282 287 293 299 304 64 267 273 279 285 291 296 302 308 314 65 276 282 288 294 300 306 312 318 324 66 284 291 297 303 309 315 322 328 334 67 293 299 306 312 319 325 331 338 344 68 302 308 315 322 328 335 341 348 354 69 311 318 324 331 338 345 351 358 365 70 320 327 334 341 348 355 362 369 376 71 329 338 343 351 358 365 372 379 386 72 338 346 353 361 368 375 383 390 397 73 348 355 363 371 378 386 393 401 408 74 358 365 373 381 389 396 404 412 420 75 367 375 383 391 399 407 415 423 431 76 377 385 394 402 410 418 426 435 443 Source: Adapted from Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report.
Metabolic syndrome is the term researchers give to the presence of any three of the following conditions:
* excess weight around the waist (waist measurement of more than 40 inches for men and more than 35 inches for women)
* high levels of triglycerides (150 mg/dL or higher)
* low levels of HDL, or "good," cholesterol (below 40 mg/dL for men and below 50 mg/dL for women)
* high blood pressure (130/85 mm Hg or higher)
* high fasting blood glucose levels (110 mg/dL or higher)
Source: National Cholesterol Education Program The National Cholesterol Education Program is a program managed by the National Heart, Lung and Blood Institute, a division of the National Institutes of Health. Its goal is to reduce increased cardiovascular disease rates due to hypercholesterolemia (elevated cholesterol , Third Report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III), National Heart, Lung, and Blood Institute National Heart, Lung, and Blood Institute,
n.pr established in 1948, this division of the National Institutes of Health is responsible for research and education on cardiovascular, pulmonary, systemic diseases, and sleep disorders. , National Institutes of Health, May 2001.
Lab Tests and What They Show
* Blood glucose. High blood glucose may be a sign that your body does not have enough insulin or does not use it well. However, a fasting measurement or oral glucose tolerance test gives more precise information.
* Insulin. An insulin measurement helps determine whether a high blood glucose reading is the result of insufficient insulin or poor use of insulin.
* Fasting glucose. Your blood glucose level should be lower after several hours without eating. After an overnight fast, the normal level is below 110 mg/dL If it is in the 110 to 125 mg/dL range, you have impaired fasting glucose or pre-diabetes. A result of 126 or higher, if confirmed on a repeat test, indicates diabetes.
* Glucose tolerance. Your blood glucose level will be higher after drinking a sugar solution, but it should still be below 140 mg/dL 2 hours after the drink. If it is higher than normal (in the 140 to 199 mg/dL range) 2 hours after drinking the solution, you have IGT or pre-diabetes, which is another strong indication that your body has trouble using glucose. A level of 200 or higher, if confirmed, means diabetes is already present.
Points to Remember
* Glucose is the simple sugar that is the main source of energy for the body's cells.
* Insulin helps cells take in blood glucose and convert it to energy.
* If you have insulin resistance, your body's cells do not respond well to insulin.
* Insulin resistance is a steppingstone step·ping·stone
1. A stone that provides a place to step, as in crossing a stream.
2. An advantageous position for advancement toward a goal. to type 2 diabetes.
* Lack of exercise and excess weight contribute to insulin resistance.
* Engaging in moderate physical activity and maintaining proper weight can help prevent insulin resistance.
* Insulin resistance plays a role in the development of cardiovascular disease, which damages the heart and blood vessels.
* Controlling blood pressure and LDL cholesterol and not smoking can also help prevent cardiovascular problems.
* The Diabetes Prevention Program confirmed that exercise and a low-calorie, low-fat diet are the best ways to prevent type 2 diabetes.
National Diabetes Information Clearinghouse
1 Information Way
Bethesda, MD 20892-3560
Phone: 1-800-860-8747 or (301) 654-3327
Fax: (301) 907-8906
The National Diabetes Information Clearinghouse (NDIC) is a service of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK is part of the National Institutes of Health under the U.S. Department of Health and Human Services Noun 1. Department of Health and Human Services - the United States federal department that administers all federal programs dealing with health and welfare; created in 1979
Health and Human Services, HHS . Established in 1978, the clearinghouse provides information about diabetes to people with diabetes and to their families, health care professionals, and the public. NDIC answers inquiries, develops and distributes publications, and works closely with professional and patient organizations and Government agencies to coordinate resources about diabetes.
Publications produced by the clearinghouse are carefully reviewed by both NIDDK scientists and outside experts. This fact sheet was reviewed by George A. Bray, M.D., Pennington Biomedical Research Center The Pennington Biomedical Research Center, located in Baton Rouge, Louisiana, is a campus of the Louisiana State University System and conducts both clinical and basic research. Its mission is to promote healthier lives through research and education in nutrition and preventive medicine. , Louisiana State University Louisiana State University and Agricultural and Mechanical College, generally known as Louisiana State University or LSU, is a public, coeducational university located in Baton Rouge, Louisiana and the main campus of the Louisiana State University System. ; and Richard F. Hamman, M.D., Dr. P.H., Department of Preventive Medicine preventive medicine, branch of medicine dealing with the prevention of disease and the maintenance of good health practices. Until recently preventive medicine was largely the domain of the U.S. and Biometrics, University of Colorado Health Sciences Center The University of Colorado Health Sciences Center (UCHSC) is part of the University of Colorado System. It has recently been merged with the University of Colorado at Denver (UCD) to form the University of Colorado at Denver and Health Sciences Center. .