Inside story.Your article "Cancer Link: Gene regulates progesterone progesterone (prōjĕs`tərōn'), female sex hormone that induces secretory changes in the lining of the uterus essential for successful implantation of a fertilized egg. effect on breast cells" (SN: 12/2/06, p. 355) made a common mistake in characterizing the mechanism of steroid-hormone receptors. These receptors are not "proteins on the cell surface" but rather, and uniquely, positioned intracellularly. Steroid hormones steroid hormone n. See steroid. pass directly from the bloodstream to the cytoplasm cytoplasm: see protoplasm. cytoplasm Portion of a eukaryotic cell outside the nucleus. The cytoplasm contains all the organelles (see eukaryote). , where they induce changes in the receptor proteins receptor protein n. An intracellular protein or protein fraction having a high specific affinity for binding agents known to stimulate cellular activity, such as a steroid hormone or cyclic AMP. , enable movement into the nucleus, and activate specific genes. MAC BLACK, SEATTLE, WASH. |
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