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In Vitro Technologies, Inc. (IVT) and SOLVO Biotechnologies Inc., Announce North American Distribution Agreement for SOLVO's In Vitro ABC Membrane Transporter Assay Products.


BALTIMORE & BUDAPEST, Hungary -- In Vitro Technologies, Inc. (IVT IVT

intravenous transfusion.
) and SOLVO Biotechnologies Inc., announced that they have formed a strategic partnership to distribute SOLVO's leading in vitro ABC ABC
 in full American Broadcasting Co.

Major U.S. television network. It began when the expanding national radio network NBC split into the separate Red and Blue networks in 1928.
 Membrane Transporter Assay Product Line in the U.S. and Canada.

IVT is a recognized leader in providing quality in vitro products and services, particularly for ADME-Tox research applications. Continuing with IVT's commitment to bring an extensive line of solutions for drug discovery and development research, IVT and SOLVO have collaborated to leverage IVT's strength in the marketplace and SOLVO's innovative Membrane Transporter products.

"We are very excited about this partnership with SOLVO and firmly believe that it will deliver additional value to pharmaceutical research customers in North America," said Dr. Paul Silber, president and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of IVT. "By making the products available from within the United States, we are making the purchase process efficient and cost-effective coupled with increased ability to provide technical support."

"By now, it is common knowledge among researchers that ABC transporters play a key role in the function of the blood-brain barrier (BBB BBB

A medium grade assigned to a debt obligation by a rating agency to indicate an adequate ability to pay interest and repay principal. However, adverse developments are more likely to impair this ability than would be the case for bonds rated A and above.
), blood-CSF barrier, blood-testis barrier, intestinal epithelia ep·i·the·li·a  
n.
A plural of epithelium.
 (absorption), airway epithelia, liver epithelia and the kidney epithelia," explained Gabor Heltovics, SOLVO's business development director. "SOLVO's leading in vitro assay systems are designed to detect interaction of test compounds with a wide array of ABC Transporter proteins found at these vital pharmacological barriers. Our products are widely used for in vitro ADME/Tox, DMPK, oncology drug research and multi-drug resistant (MDR MDR,
n See multidrug resistance.

MDR,
n the abbreviation for minimum daily requirement, specifically the Minimum Daily Requirements for Specific Nutrients compiled by the United States Food and Drug Administration.
) modulating agent discovery. We are very excited about the opportunity to work with IVT as an ideal partner to further expand the usage of our products."

SOLVO's unique technology platform is built on the following core capabilities:

--Expression of a wide array of human ABC transporters (MDR1, MDR2/3, MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MXR, BSEP and others) and rodent (rat, mouse) transporters in various expression systems (e.g. baculovirus-based insect cell).

--Functional characterization of proteins (ATPase, transport and binding data).

--Identification of new drug targets on ABC transporters.

About In Vitro Technologies, Inc.:

IVT is a privately held corporation Noun 1. privately held corporation - a corporation owned by a few people; shares have no public market
close corporation, closed corporation, private corporation
, recognized as a market leader in revolutionizing the drug discovery and development process through specialized in vitro products and services, with particular emphasis on ADME-Tox applications. IVT offers primary cell cultures from liver, kidney, and other organ systems along with microsomes and other subcellular fractions. Some of the key services offered include drug absorption (skin, gastrointestinal), metabolism (CYP CYP

In currencies, this is the abbreviation for the Cyprus Pound.

Notes:
The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion.
 inhibition, CYP induction), target organ toxicity, and bioanalytical services.

About SOLVO Biotechnology:

SOLVO Biotechnology is a privately held company privately held company

A firm whose shares are held within a relatively small circle of owners and are not traded publicly.
 specializing in R&D and commercialization of in vitro drug discovery assays, diagnostics and therapeutics related to Membrane Transport Proteins and Multidrug Resistance in cancer and other diseases.

SOLVO offers drug discovery products and services to pharmaceutical, biotechnology and consumer goods industries, relevant to many therapeutic areas and product categories.

SOLVO Biotechnology provides four different solutions for ABC (xenobiotic xen·o·bi·ot·ic
adj.
Foreign to the body or to living organisms. Used of chemical compounds.

n.
A xenobiotic chemical.



xenobiotic

any substance, harmful or not, that is foreign to the animal's biological system.
) transporter assays to be used in drug discovery:

--Membrane Preparations - to be used for ATPase Assay and Vesicular Transport Assay (direct uptake) measurements;

--Fee-For-Service Screening;

--Sublicense for the Calcein Assay;

--Custom-Made Expression and Screening Systems.
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Copyright 2005, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Oct 24, 2005
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