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Improved detection of minor ischemic myocardial injury with measurement of serum cardiac troponin I.

Currently, the biochemical diagnosis of acute myocardial infarction acute myocardial infarction (·kyōōtˑ mī·ō·karˑ·dē·  (AMI) (2) is confirmed by observing a serial rise and fall in the serum activity of creatine kinase creatine kinase /cre·a·tine ki·nase/ (ki´nas) an enzyme that catalyzes the phosphorylation of creatine by ATP to form phosphocreatine.  (CK) and its MB isoenzyme isoenzyme /iso·en·zyme/ (-en´zim) isozyme.

i·so·en·zyme
n.
See isozyme.



i
 (CK-MB) [1]. Although the use of these enzyme markers enjoys widespread acceptance, both CK and CK-MB have deficiencies. First, both CK and CK-MB are present in tissues other than the myocardium myocardium /myo·car·di·um/ (-kahr´de-um) the middle and thickest layer of the heart wall, composed of cardiac muscle.

hibernating myocardium  see myocardial hibernation, under
. A serial rise and fall of these enzymes can be observed with conditions other than AMI [2, 3]. Second, it is now recognized that profound ischemic Ischemic
An inadequate supply of blood to a part of the body, caused by partial or total blockage of an artery.

Mentioned in: Antiangiogenic Therapy, Subarachnoid Hemorrhage, Ventricular Fibrillation


ischemic
 cardiac injury can occur without myocardial myocardial /myo·car·di·al/ (-kahr´de-al) pertaining to the muscular tissue of the heart.

myocardial

pertaining to the muscular tissue of the heart (the myocardium).
 necrosis and the release of CK and CK-MB can occur without infarction [4]. Confusion therefore exists with respect to the enzymatic diagnosis of AMI, especially when release of CK and CK-MB is minimal. The diagnostic problem in AMI with an increased CK-MB in the absence of abnormally increased total CK has challenged clinicians for decades [5]. As a result, the definition of an AMI varies widely among physicians, hospitals, and countries. Recently, two new markers have become available for detection of myocardial injury. Cardiac troponin I troponin I
n.
A subunit of troponin found in muscle and cartilage that inhibits the formation of blood vessels and is under investigation as a potential cancer therapy.
 (cTnI) and cardiac troponin T (cTnT) offer improved specificity and sensitivity for detection of acute myocardial injury when compared with CK-MB in patients with suspected acute myocardial injury [3, 6, 7]. In this study, we prospectively compared serum cTnI with CK-MB mass measurements in patients with minor ischemic myocardial injury on the basis of minimal increases of total CK activity and electrocardiography or echocardiography Echocardiography Definition

Echocardiography is a diagnostic test that uses ultrasound waves to create an image of the heart muscle. Ultrasound waves that rebound or echo off the heart can show the size, shape, and movement of the heart's valves and
 findings.

Materials and Methods

This study was conducted at the Hennepin County Medical Center Hennepin County Medical Center (HCMC) is a Level I trauma center based in Minneapolis, Minnesota, the county seat of Hennepin County. The primary 422-bed facility is located on five city blocks across the street from the Hubert H. , a 450-bed teaching hospital that provides acute care for the city of Minneapolis, MN. Over an 8-month period we identified 48 consecutive patients with a diagnosis of acute minor ischemic myocardial injury. We defined minor ischemic myocardial injury as follows: (a) chest discomfort suggestive of suggestive of Decision making adjective Referring to a pattern by LM or imaging, that the interpreter associates with a particular–usually malignant lesion. See Aunt Millie approach, Defensive medicine.  acute myocardial ischemia myocardial ischemia,
n a loss of oxygen to the heart muscle caused by blockage of the coronary arteries or their branches.

myocardial ischemia 
, (b) peak total CK activity less than twice the upper reference limit (300 U/L for men; 200 U/L for women), and either (c) electrocardiogram (ECG ECG electrocardiogram.

ECG
abbr.
1. electrocardiogram

2. electrocardiograph


ECG
Also called an electrocardiogram, it records the electrical activity of the heart.
) alterations indicative of ischemic injury or evolving AMI, defined as ST-segment deviations (ST-segment depression or elevation $0.1 mV on at least two contiguous leads) or new symmetric T-wave inversions [greater than or equal to]0.1 mV, or both, or (d) two-dimensional echocardiogram ech·o·car·di·o·gram
n.
A visual record produced by echocardiography.


Echocardiogram
A non-invasive ultrasound test that shows an image of the inside of the heart.
 (echo) alterations indicative of a new or presumably pre·sum·a·ble  
adj.
That can be presumed or taken for granted; reasonable as a supposition: presumable causes of the disaster.
 new regional wall motion abnormality. All patients were assessed by detailed clinical examination during a 24-72-h period after admission. Patients were not included if they had a peak total CK activity >600 U/L or had fewer than two blood samples drawn. All the biochemical measurements vs time were based on onset of chest pain.

Serial ECGs were performed on admission and thereafter at least once daily for all patients. ECGs were evaluated by an experienced cardiologist who was unaware of the biochemical marker results. A two-dimensional echo was recommended but not required for all patients. Coronary arteriograms were obtained at the discretion of the attending clinician and were not a criterion for this study.

Clotted blood samples (serum) for analysis of CK-MB mass and cTnI were obtained at admission and every 6-8 h for 36 h. The concentration of CK-MB was measured on the Stratus II analyzer (Dade International) by a mass immunoassay Immunoassay

An assay that quantifies antigen or antibody by immunochemical means. The antigen can be a relatively simple substance such as a drug, or a complex one such as a protein or a virus.
 on the basis of a monoclonal antibody that specifically recognizes CK-MB [8]. The lower limit for detection of CK-MB was 1.0 [micro]g/L. Imprecision (CV) was 4.8% at the upper reference limit of 5.0 [micro]g/L. cTnI also was measured on the Stratus II analyzer (Dade International) by a mass immunoassay that uses two monoclonal antibodies specific for independent epitopes of cTnI [9]. The lower limit for detection of cTnI was 0.35 [micro]g/L. Imprecision (CV) was 9.5% at the upper reference limit of 0.8 [micro]g/L. Total CK activity was measured at 37 [degrees]C on a Vitros analyzer with a kinetic enzymatic method (Johnson and Johnson Co.). The upper reference limits for total CK had been determined nonparametrically, stratified stratified /strat·i·fied/ (strat´i-fid) formed or arranged in layers.

strat·i·fied
adj.
Arranged in the form of layers or strata.
 for men and women of mixed race, who were hospitalized without cardiac pathology. The biochemical marker index was defined as and calculated from the measured serum marker concentration divided by the upper reference limit (i.e., CK-MB concentration/5.0; cTnI concentration/0.8).

Statistical comparisons of cTnI and CK-MB data were analyzed by one-way and two-way analyses of variance. Results are reported as mean [+ or -] 95% confidence intervals (bars on graphs) and SD. The level of significance was set at 0.05.

Results

Between October 1995 and May 1996 we identified 48 consecutive patients with a diagnosis of acute minor ischemic myocardial injury, 27 (54%) men and 21 (46%) women (Table 1). The mean age was 65 years (range 33-96 years). The mean KILLIP class was 1.3 (range 1-3). Electrocardiographic evidence of myocardial ischemia was present in 39 (81%) of the 48 patients. The ischemic change was ST-segment depression in 13 patients, ST-segment elevation in 17 patients, T-wave inversion in 13 patients, and combined T-wave inversion and ST-segment deviation in 6 patients. New Q-waves evolved in 5 patients. A two-dimensional echo was performed in 43 (90%) of the patients. In 32 patients the echo revealed a presumed new regional wall motion abnormality. This involved the anterior wall (n = 16), the inferior wall (n = 14), or the posterior wall (n = 2). In = patients no echo was performed because of previously known ischemic cardiomyopathy ischemic cardiomyopathy Cardiology A disorder caused by myocardial hypoxia, which compromises the heart's ability to efficiently pump blood; IC may cause heart failure and is a complication of cardiac ischemia, especially affecting older ♂, a disparity that ; however, all showed evidence of ischemic injury by ECG. Coronary arteriograms were obtained in 30 of the 48 patients (62.5%). Twenty-seven of the 30 (90%) arteriograms demonstrated 90-100% occlusion in at least one coronary artery coronary artery
n.
1. An artery with origin in the right aortic sinus; with distribution to the right side of the heart in the coronary sulcus, and with branches to the right atrium and ventricle, including the atrioventricular branches and
, indicating that coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue.  was present. Eighteen of these were in patients whose total CK peaked within the reference range. Arteries in the other three patients demonstrated 20%, 40%, and 70% occlusions by angiography angiography
 or arteriography

X-ray examination of arteries and veins with a contrast medium to differentiate them from surrounding organs. The contrast medium is introduced through a catheter to show the blood vessels and the structures they supply, including
.

A summary of biochemical findings together with ECG and echo findings for all patients is presented in Table 1. The peak CK activity was within normal limits in 28 (58%) patients. The mean ([+ or -]SD) peak CK was 282 [+ or -] 144 U/L (range 55-584 U/L). The mean peak CK-MB was 16.4 [+ or -] 11.8 [micro]g/L (1.2-52.5 [micro]g/L). The mean peak cTnI was 13.2 [+ or -] 13.0 [micro]g/L (0.4-47.7 [micro]g/L). The peak cTnI concentrations correlated significantly with the peak CK-MB concentration (P <0.0001; r 5 0.58) and peak total CK activity (P = 0.002; r 5 0.45). As shown in Fig. 1, within each biochemical marker index group, cTnI was significantly increased (P <0.01) at all time periods compared with the values at 0-6 h, whereas CK-MB was increased significantly only at 7-12 h (P <0.01) and 13-18 h (P <0.05) compared with the values at 0-6 h. Between groups, the cTnI index was increased significantly (P <0.05- 0.001) compared with CK-MB from 7 to 36 h after the onset of chest pain (Fig. 1). The clinical sensitivities (defined as the number of patients with increased activity above the upper reference limit compared with all 48 patients) with 95% confidence intervals of cTnI and CK-MB at each time period following onset of chest pain are shown in Table 2. Neither marker was a good early indicator of myocardial injury at <6 h (sensitivities <40%); however, the sensitivity of cTnI at 7-36 h after the onset of chest pain was 88-100%, a substantial improvement over CK-MB (sensitivity 61-81%).

Discussion

During the past two decades, several studies have described the entity called microinfarction or non-Q-wave infarction, characterized by an increased CK-MB in the presence of normal total CK [5]. Retrospective review retrospective review,
a posttreatment assessment of services on a case-by-case or aggregate basis after the services have been performed.
 of these studies reveals frequent clinical indicators of infarction (documented by ECG and echo) with the above enzyme pattern occurring more commonly in older patients. Further, because the ECG is nondiagnostic in 50% of patients with AMI, the confirmation of the diagnosis often requires the quantitative detection of CK-MB [1]. Our study presents unique data regarding the sensitive detection of minor ischemic myocardial injury with the use of serial measurements of cTnI in 48 consecutive patients with minimal increase of total CK activity within 36 h after the onset of chest pain. Determinations of both cTnI and CK-MB mass within several time frames over 36 h after onset of chest pain demonstrated cTnI to have higher clinical sensitivity (100%) than CK-MB mass did (82%) (Table 2). Further, within each time frame after 6 h, the cTnI index was significantly increased compared with CK-MB (Fig. 1). Thus, our data suggest that detection of myocardial injury during the course of minor ischemic injury may be facilitated by the measurement of serum cTnI.

[FIGURE 1 OMITTED]

The definition of an AMI on the basis of enzyme criteria (total CK and CK-MB) varies widely, both in the US and internationally. Many investigators have required the total CK activity to exceed twice normal before establishing the diagnosis of an AMI [10]. In our study of patients that display clinical evidence for myocardial injury (Table 1), an increased total CK activity less than twice the upper limit of the reference interval accounted for 42% of the study population, with the other 58% having normal total CK activities. Further, the cardiac catheterization findings documented that substantial coronary artery disease was present in our patient study group, with 18 patients with peak total CK activities less than the upper reference limit demonstrating >90% coronary artery occlusion of at least one vessel.

Minor increases of cTnI or CK-MB can serve as markers for the occurrence of an episode of severe myocardial ischemia, regardless of whether they are indicative of reversible or irreversible injury [11-13]. Further, patients with minor ischemic myocardial injury who demonstrate a release of either CK-MB or cTnI are at increased risk for future MI and death. Thus, increases in biochemical markers may lead clinicians to certain types of treatment. A recent study examined the prognostic value of cTnI activity in patients with unstable angina or non-Q-wave MI [14]. The mortality rate at 42 days was significantly higher in the patients with measurable cTnI ([greater than or equal to]0.4 [micro]g/L) than in those with undetectable amounts (<0.4 [micro]g/L), thus providing useful prognostic information and permitting early identification of patients with an increased risk of death. Although the current study was limited because no patient follow-up data were obtained, our findings complemented the study of Antman et al. [14]. cTnI measurements have also been used for risk stratification of non-AMI patients admitted with chest pain [15]. With the use of odds ratios, Wu et al. [15] showed that poor outcomes were significantly more frequent in the increased serum cTnI group than in the normal serum cTnI group, a substantial improvement over CK-MB implications. Further, preliminary evidence has shown that increased serum cTnI could be used for screening and risk assessment in congestive heart failure congestive heart failure, inability of the heart to expel sufficient blood to keep pace with the metabolic demands of the body. In the healthy individual the heart can tolerate large increases of workload for a considerable length of time.  patients [16].

Our findings complement other studies that have demonstrated cTnI to be a very sensitive marker for AMI in patients admitted to intensive care units with a high probability of AMI, although we show cTnI not to be a sensitive early marker (Table 2) [17, 18]. The very low to undetectable cTnI values in serum from noncardiac diseased and apparently healthy patients permits use of very low discrimination values compared with higher values of CK-MB for the determination of myocardial injury. Despite the possibility that there may be other tissue sources of cTnI not yet understood, the apparent unique aspect of cTnI as being 100% tissue-specific for the myocardium [9] makes it an excellent marker to serve as a biochemical tool for detecting myocardial injury in serum as well as differentiating patients that often show falsely increased CK-MB concentrations. These include patients with chest trauma [19], cocaine-associated chest pain [20], criticalness in ill intensive care [21], muscle trauma and disease [3], and renal disease [22]. Increased cTnI amounts in patients with little or no clinical evidence suggestive of myocardial injury should alert the clinician to consider occult cardiac injury or disease. One limitation of the study design was that our population had a higher incidence of ischemic heart disease Ischemic heart disease
Insufficient blood supply to the heart muscle (myocardium).

Mentioned in: Myocarditis

ischemic heart disease 
 (as defined by ECG and echo findings and documented by angiography findings) and that our findings may not be easily extrapolated to larger patient populations. Another potential limitation of this study was its relatively small sample size; however, our data add to growing literature supporting cTnI as the preferred marker compared with CK-MB for the detection of minor ischemic cardiac injury. These findings further demonstrate the need to reevaluate the use of a twofold increase of total CK activity as a criterion for AMI.

This work was supported in part from a grant from Dade International, Inc.

Received April 16, 1997; revision accepted July 25, 1997.

References

[1.] Lee TH, Goldman L. Serum enzyme assays in the diagnosis of acute myocardial infarction. Ann Intern Med 1986;205:221-33.

[2.] Apple FS, Rogers MA, Sherman WM, Casal DG, Ivy JL. Creatine kinase MB isoenzyme adaptations in stressed human skeletal muscle. J Appl Physiol 1985;59:149-53.

[3.] Adams JE III, Bodor GS, Davila-Roman VG, Delmez JA, Apple FS, Ladenson JH, Jaffe AS. Cardiac troponin I. A marker with high specificity for cardiac injury. Circulation 1994;89:1447-8.

[4.] Piper HM, Schwartz P, Spahr R, Hutter JF, Speickermann PG. Early enzyme release from myocardial cells is not due to irreversible cell damage. J Mol Cell Cardiol 1984;16:385-8.

[5.] Lipsitz LA, Pluchino FC, Wei JY. The prevalence and prognosis of minimally elevated creatine kinase myocardial band activity in elder patients with syncope syncope

Effect of temporary impairment of blood circulation to a part of the body. It is often used as a synonym for fainting, which is loss of consciousness due to inadequate blood flow to the brain.
. Arch Intern Med 1987;147:1321-3.

[6.] Wu AHB AHB Advanced High-performance Bus
AHB Assault Helicopter Battalion
AHB Air Historical Branch
AHB Attack Helicopter Battalion
AHB Automatic Half Barriers
AHB Aussie Home Brewers
AHB Active Hyper Bass
, Feng YJ, Contois JH, Pervaiz S. Comparison of myoglobin myoglobin (mī'əglō`bĭn), protein molecule isolated from the cells of vertebrate skeletal muscle that is both a structural and functional relative of hemoglobin, the oxygen-transport protein of the blood of higher animals. , creatine kinase MB, and cardiac troponin I for diagnosis of acute myocardial infarction. Ann Clin Lab Sci 1996;26:291-300.

[7.] Katus HA, Remppis A, Neumann FJ, Scheffold T, Diederich KW, Vibar G, et al. Diagnostic efficiency of troponin T measurements in acute myocardial infarction. Circulation 1991;83:902-12.

[8.] Vaidya vaidya /vai·dya/ (vi´dyah) [Sanskrit "one who knows"] in ayurveda, a physician.  H, Maynard Y, Dietzler DN, Ladenson JH. Direct measurement of creatine creatine /cre·a·tine/ (kre´ah-tin) an amino acid occurring in vertebrate tissues, particularly in muscle; phosphorylated creatine is an important storage form of high-energy phosphate.  kinase-MB activity in serum after extraction with a monoclonal antibody specific to the MB isoenzyme. Clin Chem 1986;32:657-63.

[9.] Bodor GS, Porterfield D, Voss E, Smith S, Apple FS. Cardiac troponin I is not expressed in fetal and adult human skeletal muscle tissue. Clin Chem 1995;41:1710-15.

[10.] WHO MONICA MONICA Cardiology A WHO initiative–Multinational Monitoring of Trends & Determinants of Cardiovascular Disease–which evaluated the effects of various factors on mortality in Pts MIs  Project. Myocardial infarction and coronary deaths in the world health organization MONICA project. Circulation 1994;90:583-612.

[11.] Pettersson T. Ohlsson Tryding N. Increased CK MB (mass concentration) in patients without traditional evidence of acute myocardial infarction. A risk indicator of coronary death. Eur Heart J 1992;13:1387-92.

[12.] Adams JE III, Abendschein DR, Jaffe AS. Biochemical markers of myocardial injury. Is MB creatine kinase the choice for the 1990s? Circulation 1993;88:750-63.

[13.] White RW, Grande P, Califf L, Palmeri ST, Califf RM, Wagner GS. Diagnostic and prognostic significance of minimally elevated creatine kinase-MB in suspected acute myocardial infarction. Am J Cardiol 1985;1478-84.

[14.] Antman EM, Tanasijevic MJ, Thompson B, Schachtman M, McCabe CH, Cannon CP, et al. Cardiac-specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. N Engl J Med 1996;335:1342-9.

[15.] Wu AHB, Feng YJ, Contois JH. Prognostic value of cardiac troponin I in patients with chest pain. Clin Chem 1996;42:651-2.

[16.] Missov E, Calzolan C, Pau B. High circulating levels of cardiac troponin I in human congestive heart failure [Abstract]. J Am Coll Cardiol 1996;338A:994-5.

[17.] Tucker JF, Collins RA, Anderson AJ, Hauser BS, Kalas KALAS Korean Association for Laboratory Animal Science  J, Apple FS. Early diagnostic efficiency of cardiac troponin I and troponin T for acute myocardial infarction. Acad Emerg Med 1997;4:13-21.

[18.] Brogan GY, Hollander JE, McCuskey CF, Thode HC, Snow J, Sama A, et al. Evaluation of a new assay for cardiac troponin I vs creatine kinase MB for the diagnosis of acute myocardial infarction. Ann Emerg Med 1997;4:6-12.

[19.] Adams JE, Davila-Roman VG, Bessey PDQ (Parallel Data Query) A query optimized for massively parallel processors (MPPs). The software breaks down the query into pieces so that several parts of the database can be searched simultaneously. See SMP. , Blake DP, Ladenson JH, Jaffe AS. Improved detection of cardiac contusion CONTUSION, med. jurisp. An injury or lesion, arising from the shock of a body with a large surface, which presents no loss of substance, and no apparent wound. If the skin be divided, the injury takes the name of a contused wound. Vide 1 Ch. Pr, 38; 4 Carr. & P. 381, 487, 558, 565; 6 Carr.  with cardiac troponin I. Am Heart J 1996;131:308-12.

[20.] McLaurin M, Apple FS, Henry TD, Sharkey SW. Cardiac troponin I and T in patients with cocaine associated chest pain. Ann Clin Biochem 1996;33:1-4.

[21.] Guest TM, Ramanthan AV, Tuteur PG, Schechtman KB, Ladenson JH, Jaffe AS. Myocardial injury in critically ill patients: a frequently unrecognized complication. JAMA 1995;273:1945-9.

[22.] McLaurin MD, Apple FS, Voss, EM, Herzog CA, Sharkey SW. Cardiac troponin I, cardiac troponin T, and CK-MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clin Chem 1997;43: 976-82.

FRED S. APPLE, * ALIREZA FALAHATI, PAMELA R. PAULSEN, ELIZABETH A. MILLER, and SCOTT W. SHARKEY (1)

Clinical Laboratories 812, Hennepin County Medical Center, and Departments of Laboratory Medicine and Pathology and Medicine, University of Minnesota (body, education) University of Minnesota - The home of Gopher.

http://umn.edu/.

Address: Minneapolis, Minnesota, USA.
, School of Medicine, 701 Park Ave., Minneapolis, MN 55414.

(1) Current address: Minneapolis Cardiology Associates, 1515 St. Frances Ave., Shakopee, MN 55379.

(2) Nonstandard non·stan·dard  
adj.
1. Varying from or not adhering to the standard: nonstandard lengths of board.

2.
 abbreviations: AMI, acute myocardial infarction; cTn, cardiac troponin troponin /tro·po·nin/ (tro´po-nin) a complex of muscle proteins which, when combined with Ca2+, influence tropomyosin to initiate contraction.

tro·po·nin
n.
; CK-MB, creatine kinase MB; ECG, electrocardiogram; echo, echocardiogram.

* Author for correspondence. Fax 612-904-4229; e-mail fred.apple@co.hennepin.mn.us.
Table 1. Summary of biochemical and clinical findings for all 48
patients with minor ischemic, myocardial injury.

       Total CK           CK-MB            cTnl

PT   Peak   Minimum   Peak   Minimum   Peak   Minimum

 1     55       20     5        1       1.4     0.35
 2     68       32     2.4      1       1.8     0.35
 3     80       22     2.4      1       2.9     0.35
 4     88       40     7.9      1       9       0.35
 5    105       94     5.1      1       2.6     0.8
 6    116       53     8.8      1.6     0.9     0.35
 7    127       60     3        1       2.3     0.7
 8    130       54    14        4.6     4       0.35
 9    134      114     7.3      1.5     2.5     0.35
10    145       72    13.4      6.2     3       0.7
11    152       98     3.7      1.4     0.4     0.35
12    173      133     8.3      6.6     1.3     0.5
13    179       86     5.7      1       1.3     0.35
14    180      148     6.1      2       1.5     0.35
15    181       89     8        4.3     9.2     6.1
16    181       88     8.3      2.7     4.3     0.35
17    185       97    14.9      3.4     5.1     1.9
18    206      <20     1.2     <1.0     2.1     1.3
19    209      129    18.9     11.9     9.7     2.6
20    214      197    10.5      8.7    43.8    31.8
21    220      164     7.3      2       9       4.1
22    229      130    23.3      2.8     6.9     0.4
23    254       20     9.2      1       5.3     0.35
24    254       40    14        1       7.7     0.35
25    268      193    42.8     25.2    41.7    12.9
26    287      245    25.6     11      21.7     6.5
27    287      156    31.8      5.5    47.7    31.6
28    300      119    24.8     10.6    38.8     4
29    305       26    24.6      1      37.6     0.35
30    321       78    24.9      1.1    18.6     1.4
31    332       61    23.1      1      12       0.35
32    339       79    10        2       8.9     0.35
33    352       99    22.6      4.8     8.3     0.7
34    363      101    12.8      3.6    20.5     6.2
35    380      354     9        3.8     3.5     0.35
36    399      115    22.2      1      20.1     0.8
37    408      217     3.3      3      17.2     8.5
38    409       81     8.9      2.7    31.2     4.5
39    411      245     8.2      3.2     5.7     4.8
40    432      152    38.4      3.5    10.6     0.35
41    450      296    32.3     20.2    13.7     7.9
42    461      127    29        3.7    24      10.1
43    481      113    52.5     12.7    23.2     1.3
44    511      402    29.1     16.9     7.7     5.7
45    516      390    19.9      6.4    13.2     8.4
46    527       62    26.2      1      38.9     0.35
47    561      153    23.9      5.9    15.8     0.35
48    584       80    30.4      1      19.4     0.35

PT   ECG                          Echo

 1   Pacer                        Anterior WMA
 2   ST depression                Anterior WMA
 3   ST depression, T inversion   Anterior WMA
 4   ST elevation                 Inferior WMA
 5   T inversion                  Posterior WMA
 6   LVH, strain                  Inferior WMA
 7   No new changes               Inferior WMA
 8   LVH, strain                  Inferior WMA
 9   T inversion                  No WMA
10   LBBB                         Inferior WMA
11   ST elevation                 No WMA
12   ST depression, T inversion   Anterior WMA
13   ST depression, Q-wave        No WMA
14   ST depression                No WMA
15   ST elevation, Q-wave         Inferior WMA
16   LVH, strain                  Inferior WMA
17   ST depression                No WMA
18   ST depression                No WMA
19   ST elevation                 Anterior WMA
20   No new changes               Inferior WMA
21   T inversion                  Anterior WMA
22   ST elevation                 Anterior WMA
23   T inversion                  Anterior WMA
24   ST depression, T inversion   No WMA
25   LVH, strain                  Anterior WMA
26   ST elevation                 Anterior WMA
27   ST elevation, Q-wave         Inferior WMA
28   ST depression                No echo
29   ST elevation, T inversion    No echo
30   T inversion                  Inferior WMA
31   ST elevation, T inversion    Anterior WMA
32   ST elevation, Q-wave         Inferior WMA
33   T inversion                  Anterior WMA
34   ST depression, T inversion   No WMA
35   ST depression                No WMA
36   T inversion                  Posterior WMA
37   ST elevation                 Anterior WMA
38   ST elevation, Q-wave         Inferior WMA
39   ST elevation                 Anterior WMA
40   T inversion                  No echo
41   No new changes               Inferior WMA
42   T inversion                  No echo
43   ST elevation                 Anterior WMA
44   ST elevation                 Inferior WMA
45   ST depression                No WMA
46   ST depression                No echo
47   ST elevation                 Anterior WMA
48   ST elevation                 No WMA

WMA, wall motion abnormality; LVH, left ventricular hypertrophy.

Table 2. Clinical sensitivity and 95% confidence intervals
(CI) of cTnl and CK-MB mass in 48 minor, ischemic,
myocardial injury patients.

                           Clinical sensitivity (95% CI), %

Hours following onset of
       chest pain                CK MB         cTnl

           0-6                    34.2         38.9
                              (21.8-54.0)   (26.3-59.2)
           7-12                  81.8          90.9
                              (67.3-91.8)   (78.3-97.5)
          13-18                  75.0          92.5
                              (60.8-89.9)   (77.5-98.2)
          19-24                  66.7           100
                              (46.0-83.5)   (87.2-100)
          25-36                  61.5          88.5
                              (44.3-82.8)   (69.8-97.6)
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Title Annotation:Enzymes and Protein Markers
Author:Apple, Fred S.; Falahati, Alireza; Paulsen, Pamela R.; Miller, Elizabeth A.; Sharkey, Scott W.
Publication:Clinical Chemistry
Article Type:Clinical report
Date:Nov 1, 1997
Words:3770
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