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Immune response in brain sparks nausea.


Ailments ranging from the common cold to many types of cancer can make people nauseous nauseous /nau·seous/ (naw´shus) pertaining to or producing nausea.

nau·seous
adj.
1. Causing nausea.

2. Affected with nausea.
. A new study in the September AMERICAN JOURNAL OF PHYSIOLOGY: GASTROINTESTINAL AND LIVER PHYSIOLOGY may explain this unpleasant symptom.

Researchers at Ohio State University Ohio State University, main campus at Columbus; land-grant and state supported; coeducational; chartered 1870, opened 1873 as Ohio Agricultural and Mechanical College, renamed 1878. There are also campuses at Lima, Mansfield, Marion, and Newark.  in Columbus injected rats with an immune-signaling molecule, called tumor necrosis factor tumor necrosis factor
n. Abbr. TNF
A protein that is produced in the presence of an endotoxin, especially by monocytes and macrophages, is able to attack and destroy tumor cells, and exacerbates chronic inflammatory diseases.
, that the body produces in response to illness. They found that it caused the rats' brain stem neurons to suppress the muscle contractions required for digestion. The resulting lack of gastrointestinal activity is known to trigger nausea, loss of appetite loss of appetite Medtalk Anorexia, see there , and vomiting, explain the researchers.
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Title Annotation:immune-signaling molecule
Author:D.C.
Publication:Science News
Article Type:Brief Article
Geographic Code:1U3OH
Date:Oct 21, 2000
Words:96
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