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Icagen Announces Formation of Drug Discovery and Development Expert Panel.


RESEARCH TRIANGLE PARK Research Triangle Park, research, business, medical, and educational complex situated in central North Carolina. It has an area of 6,900 acres (2,795 hectares) and is 8 × 2 mi (13 × 3 km) in size. Named for the triangle formed by Duke Univ. , N.C. -- Icagen, Inc. (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
: ICGN ICGN International Corporate Governance Network ) announced today the formation of a drug discovery and development expert panel with the initial appointment of two distinguished pharmaceutical industry executives. Icagen's drug discovery and development expert panel, which will include individuals from both the pharmaceutical industry and academia, is being formed in order to provide ongoing advice and guidance on key scientific and clinical development issues related to the Company's portfolio of drug discovery and development programs. In addition to the Company's program in sickle cell disease sickle cell disease or sickle cell anemia, inherited disorder of the blood in which the oxygen-carrying hemoglobin pigment in erythrocytes (red blood cells) is abnormal. , these programs include ion channel-focused efforts in epilepsy, neuropathic pain, inflammation and attention deficit/hyperactivity disorder Attention deficit/hyperactivity disorder
A persistent pattern of inattention, hyperactivity and/or impulsiveness; the pattern is more frequent and severe than is typically observed in people at a similar level of development.
. The initial members of this panel from the pharmaceutical industry are Christopher Cimarusti, Ph.D. and Ian Skidmore, Ph.D. The Company expects to announce the appointment of additional members to its drug discovery and development expert panel over the next several weeks.

Dr. Cimarusti worked for over thirty-five years at Squibb and Bristol-Myers Squibb Bristol-Myers Squibb (NYSE: BMY), colloquially referred to as BMS, is a pharmaceutical corporation, formed by a 1989 merger between pharmaceutical companies Bristol-Myers Company, founded in 1887 by William McLaren Bristol and John Ripley Myers in Clinton, NY (both were , or BMS BMS
abbr.
Bachelor of Marine Science
, in a variety of senior management positions across a broad range of functional areas, including medicinal and process chemistry, pharmaceutical development and project management. His responsibilities while at BMS included overall management of the BMS exploratory development portfolio. He is the author of over sixty patents in the areas of cardiovascular, steroid and beta-lactam research, including both compound and process patents. Dr. Cimarusti received his bachelor's degree in chemistry from Providence College
This page refers to a college in Rhode Island. For the college in Manitoba, see Providence College and Theological Seminary.
Providence College is a Catholic college in Providence, Rhode Island, the state's capital city.
 and his doctorate degree in organic chemistry from Purdue University, and performed his post-doctoral research at Columbia University.

Dr. Skidmore worked for approximately thirty years at Glaxo in several senior management positions spanning a number of disciplines. Among other responsibilities, he served as chairman of the worldwide exploratory development committee, with responsibility for exploratory development across all therapeutic areas, spanning preclinical development through Phase IIa. He is a joint holder of patents on Salmeterol[R] and related molecules as long acting bronchodilators Bronchodilators Definition

Bronchodilators are medicines that help open the bronchial tubes (airways) of the lungs, allowing more air to flow through them.
 for the treatment of asthma, and led the Epivir[R] and Combivir[R] project teams. Dr. Skidmore received both his bachelor's and doctorate degrees in biochemistry from the University of Oxford.

Mark Suto, Ph.D., Vice President of Chemistry, stated, "We are delighted to announce the formation of our drug discovery and development expert panel with these two distinguished leaders from the industry, each of whom brings a unique area of expertise. In addition, over the next several weeks we intend to further expand the expertise of our expert panel with the addition of new members, as we seek to tap into expertise across the spectrum of drug development issues. We anticipate that this group will be actively involved in the ongoing evaluation, analysis and decision-making with regard to all of our drug discovery and development programs and will bring a valuable new perspective to our research and development efforts. We look forward to working with each of the members of our expert panel as we continue to advance our mission of discovering and developing novel ion channel-based pharmaceuticals."

About Icagen

Icagen, Inc. is a biopharmaceutical company based in Research Triangle Park, North Carolina North Carolina, state in the SE United States. It is bordered by the Atlantic Ocean (E), South Carolina and Georgia (S), Tennessee (W), and Virginia (N). Facts and Figures


Area, 52,586 sq mi (136,198 sq km). Pop.
, focused on the discovery, development and commercialization of novel orally-administered small molecule drugs that modulate ion channel ion channel
n.
See channel.
 targets. Utilizing its proprietary know-how and integrated scientific and drug development capabilities, Icagen has identified multiple drug candidates that modulate ion channels. The Company's four most advanced programs are:

- senicapoc for sickle cell disease, future options for the development of which the Company is evaluating subsequent to the recent termination of the Phase III ASSERT trial;

- lead compounds for epilepsy and neuropathic pain, for which the Company is conducting preclinical studies preclinical studies,
n.pl a term used to describe research done before a clinical study. May be laboratory or epidemiologic research.
;

- a lead compound for atrial fibrillation atrial fibrillation

Irregular rhythm (arrhythmia) of contraction of the atria (upper heart chambers). The most common major arrhythmia, it may result as a consequence of increased fibrous tissue in the aging heart, of heart disease, or in association with severe infection.
, for which the Company's collaborator Bristol-Myers Squibb Company is conducting preclinical studies; and

- lead compounds for dementia, including Alzheimer's disease Alzheimer's disease (ăls`hī'mərz, ôls–), degenerative disease of nerve cells in the cerebral cortex that leads to atrophy of the brain and senile dementia. , for which the Company's collaborator Astellas Pharma Inc. is conducting preclinical studies, and lead compounds for attention deficit/hyperactivity disorder, which were derived from the collaboration and for which the Company is conducting preclinical studies.

Icagen is also conducting ongoing drug discovery programs focused on new therapeutics for pain and inflammatory disorders.

Forward Looking Statements

This press release contains forward-looking statements that involve a number of risks and uncertainties. For this purpose, any statements contained herein that are not statements of historical fact may be deemed to be forward-looking statements. Without limiting the foregoing, the words "believes," "anticipates," "plans," "expects," "intends," and similar expressions are intended to identify forward-looking statements. Important factors that could cause actual results to differ materially from the expectations described in these forward-looking statements are set forth under the caption "Risk Factors" in the Company's most recent Annual Report on Form 10-K Form 10-K

A report required by the SEC from exchange-listed companies that provides for annual disclosure of certain financial information.


Form 10-K

See 10-K.
, filed with the SEC on March 6, 2007. These risk factors include risks as to the Company's ability to raise additional funding; the Company's ability to maintain compliance with NASDAQ's continued listing requirements Listing requirements

Requirements, including minimum shares outstanding, market value, and income, that are laid down by an exchange for any stock to be listed for trading.
; the Company's history of net losses and how long the Company will be able to operate on its existing capital resources; whether the Company's products will advance in the clinical trials process; the timing of such clinical trials; whether the results obtained in preliminary studies will be indicative of results obtained in clinical trials; whether the clinical trial results will warrant continued product development; whether and when, if at all, the Company's products will receive approval from the U.S. Food and Drug Administration or equivalent regulatory agencies, and for which indications, and if such products receive approval, whether they will be successfully marketed; and the Company's dependence on third parties, including manufacturers, suppliers and collaborators, including McNeil, the Company's collaborator for its sickle cell disease program. We disclaim any intention or obligation to update any forward-looking statements as a result of developments occurring after the date of this press release.
COPYRIGHT 2007 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2007, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Apr 10, 2007
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