INHALED-INSULIN TESTS PLANNED MANNKIND CORP. ENROLLING PATIENTS IN PHASE 3 SAFETY TRIAL.Byline: Daily News VALENCIA - MannKind Corp. of Valencia has begun enrolling patients in its two-year phase 3 safety trial of inhaled insulin to evaluate its pulmonary safety in diabetics. Testing in Europe began late last year and, so far, shows the inhaled insulin is more rapidly absorbed into the bloodstream, improving glucose control without increasing the risk of hypoglycemia hypoglycemia: see diabetes. hypoglycemia Below-normal levels of blood glucose, quickly reversed by administration of oral or intravenous glucose. Even brief episodes can produce severe brain dysfunction. . The system shows the inhaled insulin mimics normal insulin release. MannKind presented data on its progress earlier this month at the American Diabetes Association The American Diabetes Association, or the ADA, is an American health organization providing diabetes research, information and advocacy. Founded in 1940, the American Diabetes Association conducts programs in all 50 states and the District of Columbia, reaching hundreds of scientific sessions. ``We hope to obtain further confirmation of these findings in our phase 3 studies, moving this important new treatment for diabetes closer to commercialization,'' said Hakan Edstrom, president and chief operating officer Chief Operating Officer (COO) The officer of a firm responsible for day-to-day management, usually the president or an executive vice-president. of MannKind Corp. Now the company is expanding its manufacturing facilities in anticipation of regulatory filings and approvals for commercial use. The inhaled version of insulin - trademarked as Technosphere Insulin - is stable for at least 18 months under refrigerated re·frig·er·ate tr.v. re·frig·er·at·ed, re·frig·er·at·ing, re·frig·er·ates 1. To cool or chill (a substance). 2. To preserve (food) by chilling. conditions and for at least two months at room temperature, equivalent to or surpassing the shelf life of commercially available insulin products. The MannKind inhaled-insulin delivery system consists of a proprietary dry powder Dry Powder A slang term for cash reserves kept on hand to cover future obligations. Notes: For example, if a venture capitalist expects bad times in the IPO markets you might hear him say something like, "we want to keep enough dry powder around to keep funding our Technosphere formulation of insulin that is inhaled into the deep lung using MannKind's MedTone inhaler inhaler /in·hal·er/ (in-hal´er) 1. an apparatus for administering vapor or volatilized medications by inhalation. 2. ventilator (2). in·hal·er n. , a single-use disposable plastic cartridge containing the medication. The inhaler is lightweight and fits in the palm of the hand, and is designed for easy use. Because of that and the effectiveness seen so far in the method, company officials believe the product could change the way diabetes is treated. |
|
||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion