ICAAC clinical trials review available.ICAAC ICAAC - Interscience Conference on Antimicrobial Agents and Chemotherapy ICAAC - Iowa Community College Athletic Conference, the Inter-Science Conference on Antimicrobial Agents and Chemotherapy, was held this year in San Diego, September 27-30. This annual conference focuses mainly on the development of new antibiotics and antivirals. On October 11 HIVandHepatitis.com published a review of the HIV clinical trial presentations at ICAAC, by Charles Hicks, M.D.; it is available at: http://www.hivandhepatitis.com/2002conf/iccac2002/pages/35.html Some of the topics: * Atazanavir, an experimental protease inhibitor protease inhibitor (prō`tē-ās'), any of a class of drugs that interfere with replication of the AIDS virus (HIV), by blocking an enzyme (protease) necessary in the late stages of its reproduction. being developed by Bristol-Myers Squibb, was compared in a large international trial with efavirenz efavirenz /ef·a·vi·renz/ (ef´ah-vi?renz) an antiretroviral, inhibiting reverse transcriptase; used in the treatment of HIV infection. e·fa·vir·enz ( -fä (brand name Sustiva--or Stocrin in some countries); * 3TC (Epivir Ep·i·vir ( p![]() -vîr) was successfully dosed for once-daily use; * Coviracil, an experimental nucleoside nucleoside /nu·cleo·side/ (noo´kle-o-sid?) one of the compounds into which a nucleotide is split by the action of nucleotidase or by chemical means; it consists of a sugar (a pentose) with a purine or pyrimidine base. nu·cle·o·side (n reverse-transcriptase inhibitor, was compared with d4T d4T - Didehydrodeoxythymidine (antiviral drug); and * For certain advanced patients, a combination of amprenavir amprenavir /am·pren·a·vir/ (am-pren´ah-vir) an HIV protease inhibitor used in the treatment of HIV-1 infection. (Agenerase) and lopinavir lopinavir /lo·pin·a·vir/ (lo-pin´ah-vir) an antiviral HIV protease inhibitor, used with ritonavir in the treatment of HIV infection. plus ritonavir (Kaletra), with some extra ritonavir (Norvir Nor·vir (nôr vîr ) A trademark for the drug ritonavir. All of these trials showed promising results that may improve HIV treatment in the future. |
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