IBD and IBS: Novel mechanisms and future practice.
IBD and IBS: Novel mechanisms and future practice, S.P.L. Travis, R.C. Spiller, J.F. Colombel, P. Holzer, editors (S. Karger, Basel, Switzerland) 2010. 149 pages. Price: CHF/US $ 56.00 ISBN 978-3-8055-9385-4
Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) are two common clinical conditions in gastroenterology practice. In recent years, phenomenal advances have taken place in understanding pathogenesis of IBD and its management. On the other hand, understanding the pathogenesis of IBS is moving from the arena of psychosomatic disease to low grade gut inflammation, dysbiosis, abnormal gastrointestinal motility and sensation. In fact, in recent years, a subset of IBS is thought to be low grade IBD. Post-infection and small bowel bacterial overgrowth-associated IBS are other subsets of patients that suggest possible organic nature of this syndrome hitherto thought to be a functional disease. Considering these issues, it is very appropriate to have a book summarizing the current literature. Though several research papers are available for scientists working in this field, this book comprehensively describes the subject and will be of value to those working in these fascinating and challenging areas of luminal gastrointestinal diseases.
The book is divided into several chapters. These chapters deal with visceral and somatic pain- similarities and differences, molecular mechanisms of visceral hypersensitivity, role of emotion in pain, pharmacotherapy of pain, overlap between IBS and IBD, experimental models of stress and pain, placebo response in IBS, stress and IBD, acquisition, evolution and maintenance of normal gut microbiota, role of pathogenic microbes and commensal bacteria in IBS, bacterial flora in IBD, probiotics in IBD, aminosalicylates and other anti-inflammatory compounds for IBS, eosinophilic esophagitis, mast cell and mastocytosis and collagenous and lymphocytic colitis. All the chapters are written by experts in the field most of whom are astute clinicians as well as innovators and original researchers. There are several Figures, Tables and Flow-charts, which make the book reasonably easy to read.
Some points about this book need particular mention. The book is a concise review of extensive amount of published papers in the field. There are several chapters with varied coverage of the two important diseases, IBD and IBS. Further, this book has a "bench to bedside approach" in which the basic research is covered and extended to clinical applications. The book also gives future direction to the research in this area. This book will be an important asset to clinicians trying to remain up-to-date in IBS and IBD, postgraduate students and clinical and basic researchers.
Department of Gastroenterology
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Lucknow 226 014, India