Human Drug Metabolism: An Introduction.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c25812) has announced the addition of Human Drug Metabolism: An Introduction to their offering There is a gap in the market for a concise, basic drug metabolism textbook that is written at an accessible level for the broad range of students who take this course, especially vocational medical and dental students. Drug metabolism textbooks currently available are too detailed and provide few clinical examples to engage student interest. Topics Covered CHAPTER 1: INTRODUCTION. 1.1 Therapeutic Window. 1.2 Consequences of Drug Concentration Changes. 1.3 Clearance. 1.4 Hepatic Extraction and Intrinsic Clearance. 1.5 First Pass and Plasma Drug Levels. 1.6 Drug and Xenobiotic xen·o·bi·ot·ic adj. Foreign to the body or to living organisms. Used of chemical compounds. n. A xenobiotic chemical. xenobiotic any substance, harmful or not, that is foreign to the animal's biological system. Metabolism. CHAPTER 2: DRUG BIOTRANSFORMATIONAL SYSTEMS - ORIGINS AND AIMS. 2.1 Biotransforming enzymes. 2.2 Threat of Aromatic Hydrocarbons. 2.3 Cell Communication. 2.4 Potential Food Toxins. 2.5 Sites of Biotransforming Enzymes. 2.6 Biotransformation biotransformation /bio·trans·for·ma·tion/ (-trans?for-ma´shun) the series of chemical alterations of a compound (e.g., a drug) occurring within the body, as by enzymatic activity. . CHAPTER 3: HOW PHASE I SYSTEMS METABOLISE SUBSTRATES. 3.1 Introduction. 3.2 Capture of Lipophilic lipophilic, adj/n the ability to dissolve or attach to lipids. lipophilic (lipōfil´ik), adj 1. showing a marked attraction to, or solubility in, lipids. 2. Molecules. 3.3 Cytochrome P450s Basic Structure. 3.4 CYPs-Main and Associated Structures. 3.5 CYP CYP In currencies, this is the abbreviation for the Cyprus Pound. Notes: The currency market, also known as the Foreign Exchange market, is the largest financial market in the world, with a daily average volume of over US $1 trillion. Substrate Specificity and Regulation. 3.6 Main Human CYP Families. 3.7 Cytochrome P450 Catalytic Cycle. 3.8 Real-life Operations. 3.9 CYP Isoforms: how aims are translated into function. 3.10 Aromatic Ring Hydroxylation hydroxylation addition of -OH groups to a molecule. . 3.11 Alkyl alkyl /al·kyl/ (al´k'l) the monovalent radical formed when an aliphatic hydrocarbon loses one hydrogen atom. al·kyl n. Oxidations. 3.12 Rearrangement and Reactions. 3.13 Other Oxidation Processes. 3.14 Reduction Reactions. 3.15 Control of CYP Metabolic Function. CHAPTER 4: INDUCTION OF PHASE I SYSTEMS. 4.1 Introduction. 4.2 Causes of Accelerated Clearance. 4.3 Enzyme Induction. 4.4 Mechanisms of Enzyme induction. 4.5. Induction-General Clinical Aspects. CHAPTER 5: PHASE I ENZYME INHIBITION. 5.1 Introduction. 5.2 Inhibition of Metabolism-general aspects. 5.3 Mechanisms of Inhibition. 5.4 Cell transport systems and CYP 3A inhibitors. 5.5.Clinical Consequences of Drug Inhibition. 5.6. Use of Inhibitors for Positive Clinical Intervention. CHAPTER 6: PHASE II and III PROCESSES. 6.1 Introduction. 6.2 Glucuronidation. 6.3 Sulphation. 6.4 The GSH GSH reduced glutathione. GSH reduced glutathione. System. 6.5 Glutathione S-Transferases. 6.6 Epoxide hydrolases. 6.7 Acetylation acetylation /acet·y·la·tion/ (ah-set?i-la´shun) introduction of an acetyl radical into an organic molecule. a·cet·y·la·tion n. . 6.8 Methylation methylation, n a phase-II detoxification pathway in the liver; methyl groups combine with toxins to rid the body of various substances. methylation (meth´ . 6.9 Esterases/amidases. 6.10 Amino Acid Conjugation amino acid conjugation, n a phase II detoxification pathway that occurs in the liver in which amino acids in-cluding arginine, glutamine, glycine, ornithine, and taurine, combine with toxins and other substances. (Glycine glycine (glī`sēn), organic compound, one of the 20 amino acids commonly found in animal proteins. Glycine is the only one of these amino acids that is not optically active, i.e. or Glutamate). 6.11 Phase III Processes. CHAPTER 7: FACTORS AFFECTING DRUG METABOLISM. 7.1 Introduction. 7.2 Genetic Polymorphisms. 7.3 Effects of Age on Drug Metabolism. 7.4 Effects of Diet on Drug Metabolism. 7.5 Gender Effects. 7.6 Effects of Disease on Drug Metabolism. 7.7 Summary. CHAPTER 8 ROLE OF METABOLISM IN DRUG TOXICITY. 8.1 Adverse Drug Reactions. 8.2 Reversible Drug Adverse Effects Type A. 8.3. Irreversible Toxicity (Type B). 8.4 Type B1 Necrotic Reactions. 8.5. Type B2 Reactions: Immunotoxicity. 8.6 Type B3 Reactions: Role of Metabolism in Cancer. 8.7 Summary Of Biotransformational Toxicity. APPENDIX A - METHODS IN DRUG METABOLISM. A.1 Introduction. A.2 Human liver microsomes. A.3 Human hepatocytes. A.4 Heterolohous systems. A.5 Toxicological metabolism-based assays. A.6 In silico studies. APPENDIX B - METABOLISM OF MAJOR ILICIT DRUGS. B.1 Introduction. B.2 Opiates. B.3 Cocaine. B.4 Hallucinogens. B.5 Amphetamines:ecstacy (MDMA MDMA 3,4-methylenedioxymethamphetamine. MDMA n. 3,4-Methylenedioxymethamphetamine; a mescaline analog. MDMA 3,4 methylenedioxy-methamphetamine. See Ecstasy. ). B.6 Cannabis. B.7 PCP PCP abbr. 1. phencyclidine 2. primary care physician Pneumocystis carinii pneumonia (PCP) . APPENDIX C - EXAMINATION TECHNIQUES. C.1 Introduction. C.2 A first-class answer. C.3 Preparation. C.4 The day of reckoning. APPENDIX D - SUMMARY OF MAJOR CYP ISOFORMS AND THEIR SUBSTRATES, INHIBITORS AND INDUCERS. SUGGESTED FURTHER READING. Index. Summary Drug metabolism is a core area of pharmacology. Before any drug can be licensed it is essential to know how the body metabolises the drug, and the short and long-term effects it has on the body. It is an area of rapid advancement, which brings together the fields of pharmacy, pharmacology and medicine. This new text provides a concise, user-friendly introduction to drug metabolism that is ideal for undergraduates. Focusing on a conceptual understanding of the drug metabolism system, the book illustrates the basic mechanisms on how xenobiotics are detected, chemically modified and then eliminated from human systems. For more information visit http://www.researchandmarkets.com/reports/c25812 |
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