How 'triggering event' in cancer occurs.Byline: ANI Washington, Oct 30 (ANI): A research team at the University of Michigan (body, education) University of Michigan - A large cosmopolitan university in the Midwest USA. Over 50000 students are enrolled at the University of Michigan's three campuses. The students come from 50 states and over 100 foreign countries. Comprehensive Cancer Center, including an Indian-origin scientist, has found how two genes fuse together and lead to prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men. . The study found that pieces of chromosome relocate near each other after exposure to the hormone androgen, which sets the scene for the gene fusion to occur. "This work shows the origin of how the gene fusion is actually created and perhaps the origin of prostate cancer itself. This is a triggering event Triggering Event A certain milestone or event that a participant in a qualified plan must experience in order to be eligible to receive a distribution from a qualified plan. for the genesis of prostate cancer," said study author Dr. Arul Chinnaiyan. In 2005, the researchers identified a prostate-specific gene called TMPRSS TMPRSS Transmembrane Protease, Serine 2 that fuses with the gene ERG, which is known to play a role in prostate cancer. Their earlier research has shown that this gene fusion acts as an "on switch" to trigger prostate cancer. In the current study, the researchers focused on what causes the gene fusion to occur. They took prostate cancer cells that did not reflect the gene fusion but that were sensitive to androgen, a male hormone known to play a role in some prostate cancers. They exposed the cells to androgen and found that two pieces of chromosome that are normally far apart are relocated near each other. Then, the researchers applied radiation to the androgen-stimulated cells. This stress or insult to the cells - designed to induce chromosomal breaks - led to the gene fusion to occur. "We thought the gene fusions occurred as a chance event, but it's not. Chromosomes can actually be induced in three-dimensional space to be close to each other. Then when an insult to the DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. occurs, the fusion happens," said lead study author Dr. Ram-Shankar Mani Mani (mä`nē): see Manichaeism. Mani or Manes or Manichaeus (born April 14, 216, southern Babylonia—died 274?, Gundeshapur) Persian founder of Manichaeism. . The researchers believe the findings could have implications for gene fusions that occur in other cancer types. The researchers suggest that by understanding how gene fusions occur, screening tools or prevention strategies could potentially be developed. The finding has been published in Science Express. (ANI) Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency. (ANI) - All Rights Reserved. Provided by Syndigate.info an Albawaba.com company |
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