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Hospital Infection Control in Hematopoietic Stem Cell Transplant Recipients.

Guidelines for Preventing Opportunistic Infections Among Hematopoietic Stem Cell Hematopoietic stem cell
A cell that can develop into any type of specialized blood cell.

Mentioned in: Umbilical Cord Blood Banking
 Transplant Recipients contains a section on hospital infection control including evidence-based recommendations regarding ventilation, construction, equipment, plants, play areas and toys, health-care workers, visitors, patient skin and oral care, catheter-related infections, drug-resistant organisms, and specific nosocomial infections. These guidelines are intended to reduce the number and severity of hospital infections in hematopoietic stem cell transplant recipients.

The Centers for Disease Control and Prevention Centers for Disease Control and Prevention (CDC), agency of the U.S. Public Health Service since 1973, with headquarters in Atlanta; it was established in 1946 as the Communicable Disease Center.  (CDC See Control Data, century date change and Back Orifice.

CDC - Control Data Corporation
), the Infectious Diseases Society of America The Infectious Diseases Society of America (IDSA) is a medical association representing physicians, scientists and other health care professionals who specialize in infectious diseases.  (IDSA IDSA Infectious Diseases Society of America
IDSA Industrial Designers Society of America
IDSA Interactive Digital Software Association
IDSA Institute for Defense Studies and Analyses (India)
IDSA International Dark Sky Association
), and the American Society for Blood and Marrow Transplantation (ASBMT ASBMT American Society for Blood and Marrow Transplantation ) sponsored the Guidelines for Preventing Opportunistic Infections Among Hematopoietic Stem Cell Transplant Recipients. This document was drafted in 1997 by a working group of infectious disease and transplant experts,(1) revised extensively from 1997 to 1999, and released for public comment on September 15, 1999, on the CDC website. The final document was published in CDC's Morbidity and Mortality Weekly Report Morbidity and Mortality Weekly Report (MMWR) is a weekly epidemiological digest for the United States published by the Centers for Disease Control and Prevention. The 5 June 1981 issue of the MMWR published the cases of five men in what turned out to be the first report of AIDS.  on October 20, 2000, and in the Biology of Blood and Marrow Transplantation in late 2000. The term hematopoietic stem cell transplant recipients (HSCT HSCT Hematopoietic Stem Cell Transplant
HSCT High Speed Civil Transport
HSCT High School Competency Test
HSCT Hypersonic Commercial Transport
HSCT Hygiène Sécurité Conditions de Travail en Collectivité Territoriale
HSCT Hayling Sentence Completion Task
) is preferable to "bone marrow transplant bone marrow transplant: see bone marrow.  recipients" because the new term more accurately describes the current state of transplantation, which may involve harvesting donor cells from peripheral blood, umbilical cord blood umbilical cord blood Transplantation A source of primitive and stem cells that can be used to reconstitute BM destroyed by aplastic anemia or by RT or chemotherapy for CA, lymphoproliferative malignancies. See Bone marrow transplantation, Stem cell therapy. , or bone marrow (1).

The document is an evidence-based statement of recommended strategies for preventing opportunistic infections in HSCT recipients. The prevention strategies are rated by the strength of the recommendation and the quality of the evidence supporting it. This rating system was developed by IDSA and the U.S. Public Health Service for use in the guidelines for the prevention of opportunistic infections in persons infected with HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States.  (2). The rating system allows the importance of each recommendation to be assessed. An A rating indicates strong evidence for efficacy and clinical benefit and an intervention that should always be offered; an intervention with a B rating is supported by moderate evidence and generally should be offered; a C rating indicates an optional intervention because evidence is insufficient to support a recommendation or evidence for efficacy might not outweigh adverse effects; a D rating indicates that moderate evidence for lack of efficacy or adverse outcome supports recommending against the intervention; and an E rating indicates strong evidence that an intervention is contraindicated because of lack of efficacy or adverse effects. Three categories are used to rate the quality of evidence supporting each recommendation, with I the highest, indicating evidence from at least one randomized ran·dom·ize  
tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es
To make random in arrangement, especially in order to control the variables in an experiment.
, controlled trial; II indicating evidence from at least one well-designed clinical trial without randomization randomization (ranˈ·d·m , from cohort or case-controlled analytic studies, or from multiple time-series, or dramatic results from uncontrolled experiments; and III indicating evidence from authorities' opinions based on clinical experience, descriptive studies, or reports of expert committees. This article summarizes the hospital infection control guidelines in the Guidelines for Preventing Opportunistic Infections Among Hematopoietic Stem Cell Transplant Recipients, with ratings in brackets.


All allogeneic HSCT recipients should be placed in rooms with [is greater than] 12 air exchanges per hour (3,4) and point-of-use, high-efficiency ([is greater than] 99%) particulate air (HEPA HEPA  
1. high-efficiency particulate air

2. high-efficiency particulate arresting
) filters capable of removing particles [is greater than or equal to] 0.3 [micro]m in diameter (4-7) [AIII AIII Autologic Information International, Inc. ]. This recommendation is particularly important for facilities undergoing construction and renovation (8). The need for environmental HEPA filtration for autologous autologous /au·tol·o·gous/ (aw-tol´ah-gus) related to self; belonging to the same organism.

 HSCT recipients has not been established; however, the use of HEPA-filtered rooms should be considered for autologous HSCT recipients who have prolonged neutropenia, the major risk factor for nosocomial nosocomial /noso·co·mi·al/ (nos?o-ko´me-il) pertaining to or originating in a hospital.

1. Of or relating to a hospital.

 aspergillosis Aspergillosis Definition

Aspergillosis refers to several forms of disease caused by a fungus in the genus Aspergillus. Aspergillosis fungal infections can occur in the ear canal, eyes, nose, sinus cavities, and lungs.
 [CIII CIII Schedule III Controlled Substance (USA) ].

The use of laminar air flow rooms for bone marrow transplant recipients has been controversial. Such rooms contain filtered air that moves in parallel, unidirectional flow; the air enters the room from one wall and exits the room on the opposite wall (3). Although LAF protects patients from infection in aspergillosis outbreaks during hospital construction (9,10), its routine use may not be valuable for all HSCT recipients (11). Since 1983, rooms with laminar air flow have been preferred for allogeneic HSCT recipients with aplastic anemia and human leukocyte antigen-identical sibling donors because the reported death rate of patients in regular rooms was nearly four times higher (12). However, the survival of aplastic anemia HSCT recipients in the late 1990s exceeds that reported in the early 1980s, and no study has yet determined whether survival of HSCT recipients with aplastic anemia improves when they are treated in rooms with laminar air flow. Therefore, such rooms need not be constructed for every HSCT recipient, and use of available rooms is optional [CII].

Hospital rooms should have directed airflow so that air enters at one side of the room and is exhausted at the opposite side (5) [BIII]. Each hospital room should be well sealed (e.g., around windows and electrical outlets) (5) [BIII]. To provide consistent positive pressure in the HSCT recipient's room, consistent pressure differentials should be maintained between patients' rooms and the hallways or anterooms at [is greater than] 2.5 Pascals (3,4) [BIII]. In general, air pressure in hospital rooms of HSCT recipients should be higher than in adjoining' hallways, toilets, and anterooms.

Backup emergency power and redundant systems should be provided to maintain room pressurization Pressurization generally refers to the application of pressure in a given situation or environment; and more specifically refers to the process by which atmospheric pressure is maintained in an isolated or semi-isolated atmospheric environment (for instance, in an aircraft, or  and a constant number of air exchanges in HSCT units when the central ventilation system is shut off for maintenance and repair (131) [BIII]. In addition, protocols should be developed to protect HSCT units from bursts of mold spores when air-handling systems are restarted after routine maintenance [BIII].


Hospital construction and renovation have been associated with increased risk for nosocomial fungal infection, especially aspergillosis, among severely immunocompromised immunocompromised /im·mu·no·com·pro·mised/ (-kom´pro-mizd) having the immune response attenuated by administration of immunosuppressive drugs, by irradiation, by malnutrition, or by certain disease processes (e.g., cancer).  patients (14). Therefore, people responsible for HSCT unit construction or renovation should consult published recommendations for environmental controls (15,16) [AIII]. Planning for construction or renovation should include strategies for intensified aspergillosis-control measures [AIII]. The planning committee should include engineers, architects, housekeeping staff, infection control personnel, the director of the HSCT unit, administration representatives, and safety officers [BIII].


HSCT units should follow published guidelines for hospital isolation practices, including CDC guidelines for the prevention of nosocomial infections (17,18) [AIII]. However, the efficacy of specific isolation and barrier precautions in preventing nosocomial infections in HSCT recipients has not been evaluated. HSCT recipients should be placed in private rooms [BIII]. When indicated, HSCT recipients should also be placed on airborne, droplet, or contact precautions in addition to standard precautions (17) [AIII]. Careful observation of isolation precautions is important to prevent transmission of infectious agents among HSCT recipients, health-care workers, and visitors.

Hand Hygiene

Hand hygiene is the single most effective procedure for preventing nosocomial infection (17). Everyone, especially health-care workers, should wash hands before entering and after leaving rooms of HSCT recipients and candidates undergoing conditioning therapy (chemotherapy and radiation) (17,19) or before and after any direct contact with patients, regardless of whether hands were soiled [AI]. HSCT recipients should be encouraged to practice good hand hygiene (e.g., washing hands before eating, after using the toilet, before and after touching a wound) [BIII]. Hands should be washed with antimicrobial soap and water [AIII]; hygienic hand rubs are also an acceptable means of maintaining hand hygiene (20,21). Health-care workers wearing gloves should put them on in the patient's room after handwashing and then discard them in the same patient's room before washing hands again on exiting the room. Gloves should always be changed between patients or before touching a clean area if the gloves become soiled (e.g., change gloves after touching the perineum perineum /peri·ne·um/ (-ne´um)
1. the pelvic floor and associated structures occupying the pelvic outlet, bounded anteriorly by the pubic symphysis, laterally by the ischial tuberosities, and posteriorly by the coccyx.
 and before touching a clean area) [AIII]. Appropriate gloves should be used by all persons handling potentially contaminated biological materials [AII].


HSCT units should monitor opened and unopened wound-dressing supplies such as adhesive bandages (22) and surgical and elastic adhesive tape (23) to detect mold contamination and prevent cutaneous transmission to patients [BII]. All bandages and wound dressings should be discarded that are out of date, have damaged packaging, or are visually contaminated by construction debris, moisture. [BIII].


Exposure to plants and flowers has not been conclusively shown to cause fungal infections in HSCT recipients. However, most experts strongly recommend that plants and dried or fresh flowers not be allowed in the hospital rooms of HSCT recipients or candidates undergoing conditioning therapy because Aspergillus Aspergillus

Any fungus of the genus Aspergillus of the Fungi Imperfecti (form-class Deuteromycetes). Species for which the sexual phase is known are placed in the order Eurotiales. A. niger causes black mold on some foods; A. niger, A. flavus, and A.
 spp. have been isolated from the soil of potted ornamental plants (e.g., cacti), the surface of dried flower arrangements, and fresh flowers (5,7,24) [BIII].

Play Areas and Toys

Play areas for pediatric pediatric /pe·di·at·ric/ (pe?de-at´rik) pertaining to the health of children.

Of or relating to pediatrics.
 HSCT recipients and candidates undergoing conditioning therapy should be cleaned and disinfected Disinfected
Decreased the number of microorganisms on or in an object.

Mentioned in: Isolation
 weekly and as needed [BIII]. Only toys, games, and videos that can be kept clean and disinfected should be allowed in the HSCT unit [BIII]. HSCT units and clinics should follow published recommendations for washing and disinfecting toys (25) [BIII].

Health-Care Workers

Each hospital or HSCT center should prepare a written comprehensive policy on the immunization of hospital personnel that meets current recommendations of CDC, the Advisory Committee on Immunization Practices The Advisory Committee on Immunization Practices (ACIP) consists of fifteen advisors to the Centers for Disease Control and Prevention (CDC), selected by the Secretary of the United States Department of Health and Human Services, to provide advice and guidance on the most effective , and the Healthcare Infection Control Practices Advisory Committee (26) [BIII]. Immunizations are needed to prevent transmission of vaccine-preventable diseases to HSCT recipients and candidates undergoing conditioning therapy. In general, health-care workers should be immune to measles, mumps, rubella, and especially varicella varicella: see chicken pox.  and influenza.


Hospitals should have written policies for screening HSCT unit visitors, especially children, for potentially infectious conditions. Such screening should be performed by clinically trained health-care personnel [BII]. Visitors who have communicable infectious diseases such as upper respiratory infection Noun 1. upper respiratory infection - infection of the upper respiratory tract
respiratory infection, respiratory tract infection - any infection of the respiratory tract
 or flulike illness, recent exposure to communicable diseases, an active shingles rash (whether covered or not), a Varicella zoster-like rash within 6 weeks of receiving a chickenpox vaccine, or a history of receiving an oral polio vaccine within the previous 3 to 6 weeks should not be allowed to enter the HSCT unit or have direct contact with HSCT recipients or candidates undergoing conditioning therapy [AII].

Patient Skin Care

Skin care during neutropenia should include daily inspection of sites likely to be portals of infection, such as the perineum and intravascular intravascular /in·tra·vas·cu·lar/ (in?trah-vas´ku-lar) within a vessel.

Within one or more blood vessels.
 access sites [BIII]. HSCT recipients and candidates undergoing conditioning therapy should maintain good perineal perineal /peri·ne·al/ (-ne´al) pertaining to the perineum.
The diamond-shaped region of the body between the pubic arch and the anus.
 hygiene to minimize loss of skin integrity and risk for infection [BIII]. To facilitate this, HSCT units should develop special protocols for patient perineal care. To prevent vaginal or cervical irritation and abrasions, menstruating men·stru·ate  
intr.v. men·stru·at·ed, men·stru·at·ing, men·stru·ates
To undergo menstruation.

[Late Latin m
 immunosuppressed Immunosuppressed
A state in which the immune system is suppressed by medications during the treatment of other disorders, like cancer, or following an organ transplantation.

Mentioned in: Fifth Disease
 HSCT recipients should not use tampons [DIII]. (Immunosuppressed HSCT recipients are defined as being <24 months post-HSCT, on immunosuppressive therapy, or having graft-versus-host disease.) The use of rectal thermometers, enemas Enemas Definition

An enema is the insertion of a solution into the rectum and lower intestine.

Enemas may be given for the following purposes:
, suppositories suppositories, solid capsules made of materials that melt at body temperature and are used to deliver medicinal substances into the rectum.
, and rectal exams are contraindicated for HSCT recipients because of the risk for skin or mucosal breakdown [DIII].

Oral and Dental Care

Establishing optimal periodontal health before HSCT is one of the most important steps patients can take to avoid oral infections, and maintaining good oral hygiene after the transplant can minimize the severity and facilitate healing of mucositis, especially before engraftment engraftment /en·graft·ment/ (en-graft´ment) incorporation of grafted tissue into the body of the host.
The process of transplanted stem cells reproducing new cells.
 [BIII]. All HSCT candidates should receive a dental evaluation and relevant treatment before conditioning therapy begins (27) [AIII]. Likely sources of dental infection should be rigorously eliminated [AIII].

HSCT recipients with mucositis and HSCT candidates undergoing conditioning therapy should maintain good oral hygiene by rinsing the mouth four to six times a day with sterile water, normal saline, or sodium bicarbonate solutions (27) [AIII]. HSCT recipients and candidates should brush their teeth at least twice a day with a soft regular toothbrush (27) [BIII]. Patients who cannot tolerate these brushings may use ultra-soft toothbrushes or sponge or foam toothettes (Sage Products, Crystal Lake, IL) [CIII], but these products are less effective in removing dental debris (17). Toothpaste is optional, depending on patient tolerance (27) [CIII]. HSCT recipients and candidates undergoing conditioning therapy who are skilled at dental flossing should floss daily if this can be done without trauma [BIII].

Prevention of Bacterial Infections Related to Intravascular Catheters

HSCT units are advised to implement published guidelines for preventing infections related to the use of intravascular devices (28) [AIII]. HSCT units should avoid tap-water contact with the central venous catheter central venous catheter
A catheter passed through a peripheral vein and ending in the thoracic vena cava; it is used to measure venous pressure or to infuse concentrated solutions.
 site [BIII]. To prevent bloodstream infections associated with the use of needleless intravenous-access devices, HSCT recipients should cover and protect the catheter tip or end cap during bathing or showering to protect it from tap-water contamination, change the device in accordance with manufacturers' recommendations, and have a care giver perform IV infusions whenever possible (29) [BII].

Drug-Resistant Organisms

Avoiding the misuse of antibiotics will decrease the emergence of drug-resistant strains of bacteria. Therefore, HSCT units should routinely review patterns of use for antibiotics and should prudently prescribe all antibiotics, especially vancomycin, to prevent the emergence of multidrug-resistant organisms. Medical and ancillary staff members responsible for monitoring antimicrobial use patterns should routinely review vancomycin use (30) [AIII]. Vancomycin and all other antibiotics, especially third-generation cephalosporins Cephalosporins Definition

Cephalosporins are medicines that kill bacteria or prevent their growth.

Cephalosporins are used to treat infections in different parts of the body—the ears, nose, throat, lungs, sinuses, and
 and antianaerobic agents such as metronidazole metronidazole /met·ro·ni·da·zole/ (-ni´dah-zol) an antiprotozoal and antibacterial effective against obligate anaerobes; used as the base or the hydrochloride salt. It is also used as a topical treatment for rosacea. , must be used judiciously (30) [AII].

Specific Nosocomial Infections

Nosocomial pathogens are potential threats to all patients; however, if infected, HSCT recipients are at risk for more severe disease. Nosocomial pathogens of concern include Legionella Legionella /Le·gion·el·la/ (le?jah-nel´ah) a genus of gram-negative, aerobic, rod-shaped bacteria (family Legionellaceae), normal inhabitants of lakes, streams, and moist soil; they have often been isolated from cooling-tower water,  spp., methicillin-resistant Staphylococcus aureus methicillin-resistant Staphylococcus aureus Methicillin-aminoglycoside resistant Staphylococcus aureus, MRSA An organism with multiple antibiotic resistances–eg, aminoglycosides, chloramphenicol, clindamycin, erythromycin, rifampin, tetracycline, , Streptococcus viridans, and Mycobacterium tuberculosis, and community respiratory viruses such as influenza, respiratory syncytial virus respiratory syncytial virus (sĭnsĭsh`əl): see cold, common. , adenovirus adenovirus

Any of a group of spheroidal viruses, made up of DNA wrapped in a protein coat, that cause sore throat and fever in humans, hepatitis in dogs, and several diseases in fowl, mice, cattle, pigs, and monkeys.
, and parainfluenza virus.


Clinicians should always consider infection with Legionella spp. in the differential diagnosis of pneumonia in HSCT recipients. Because HSCT recipients are at much higher risk for disease and death from legionellosis (31), periodic routine culturing for legionellae in water samples from the transplant units' potable water supply may be part of an overall prevention strategy in such units [CIII]. However, the optimal methods (frequency, number of sites) for environmental surveillance cultures in transplant units have not been determined, and the cost-effectiveness of this strategy has not been evaluated. Because HSCT recipients are at high risk for legionellosis and a safe concentration of legionellae organisms in potable water has not been determined, the goal, if environmental surveillance is undertaken, should be to maintain water systems with no detectable organisms [AIII]. Clinicians must maintain a high index of suspicion index of suspicion Medtalk A phrase broadly used to indicate how seriously a particular disease is being entertained as a diagnosis; as an example, there is a high IOS that rapid and unexplained weight loss in an elderly Pt is due to pancreas CA, and a low IOS that  for legionellosis in transplant patients with nosocomial pneumonia even when environmental surveillance cultures do not yield legionellae [AIII].

Community Respiratory Virus Infections

Clinicians should institute appropriate precautions and infection control measures to prevent nosocomial pneumonia in hospitalized HSCT recipients and candidates undergoing conditioning therapy, especially during community or nosocomial respiratory virus outbreaks (5) [AIII]. Even when there is no nosocomial or community outbreak of respiratory virus infections, which are emerging infections in HSCT recipients, everyone who enters an HSCT unit, including visitors and health-care workers, should be screened daily for symptoms of upper respiratory infection [BIII]. Some experts recommend that health-care workers who work in HSCT units should provide daily verification (e.g., sign-in sheets) that they are symptom free before being allowed to care for patients. To minimize the risk for transmission, health-care workers and visitors with upper respiratory symptoms should be restricted from contact with HSCT recipients and candidates undergoing conditioning therapy [AIII]. All health-care workers with upper respiratory infection symptoms should be restricted from patient contact and reassigned to nonpatient care duties until their symptoms resolve [BIII]. Visitors with such symptoms should be asked to defer their visit to the HSCT unit until their symptoms resolve [BIII].

Viral shedding among HSCT recipients with community respiratory virus infection has been documented to last up to 4 months for influenza (32), 2 years for adenovirus (33), and 22 days for respiratory syncytial virus (34); however, viral shedding has been reported to last up to 112 days in a child with severe combined immunodeficiency Severe Combined Immunodeficiency Definition

Severe combined immunodeficiency (SCID) is the most serious human immunodeficiency disorder(s). It is a group of congenital disorders in which both the humoral part of the patient's immune system and the cells
 (35). Therefore, to prevent nosocomial transmission, HSCT units should factor such possible prolonged viral shedding into policy decisions about duration of precautions for infected HSCT recipients or candidates undergoing conditioning therapy [CIII].

Mycobacterium tuberculosis

HSCT candidates should be screened for tuberculosis (TB) by a careful medical history and chart review to ascertain any history of TB exposure [AIII] because latent TB infection is more likely to progress to active disease among persons who are immunocompromised (36). HSCT units should also consider administering a tuberculin skin test Tuberculin Skin Test Definition

Tuberculosis (TB) is an airborne infectious disease caused by the bacteria Mycobacterium tuberculosis. Besides culturing in the laboratory, the two most common types of tests to screen for exposure to this disease
 (TST TST 1 Toxic shock toxin 2 Treadmill stress test, see there ) by the Mantoux method with 5 tuberculin tuberculin /tu·ber·cu·lin/ (-lin) a sterile solution containing the growth products of, or specific substances extracted from, the tubercle bacillus; used in various forms in the diagnosis of tuberculosis; see also under test.  units of purified protein derivative purified protein derivative

see purified protein derivative of tuberculin.
 (PPD (1) (Parallel Presence Detect) The method used by earlier SIMM memory modules to communicate their capacity to the computer. A binary number coming from a parallel set of pins was read by the system, with each pin representing one bit. Contrast with SPD. ) [CIII]; however, the TST may not be reliable in immunocompromised patients. Patients with a recent positive TST result or a history of a positive TST result and no prior preventive therapy should be given a chest X ray and evaluated for active TB (36) [AI]. Because immunocompromised patients have a decreased ability to mount a delayed hypersensitivity response, a positive TST result for them is defined as [is greater than or equal to] 5 mm of in duration (36) rather than [is greater than or equal to] 10 mm [CIII]. Since immunosuppressive therapy decreases the sensitivity of the TST, HSCT providers should not rely solely on the TST to determine presence of latent TB infection and need for preventive therapy [DIII]. Instead, a full 9-month course of isoniazid isoniazid (ī'sōnī`əzĭd), drug used to treat tuberculosis. Also known as isonicotinic acid hydrazide, isoniazid is the most effective antituberculosis drug currently available.  preventive therapy should be given to immunocompromised HSCT recipients or candidates who have had close contact with someone with active, infectious (i.e., sputum-smear positive) pulmonary or laryngeal TB, regardless of the HSCT recipient's or candidate's TST status (36) [BIII]. Routine energy screening results may not be reliable for HSCT recipients and candidates undergoing conditioning therapy, and therefore such screening is not recommended [DIII]. HSCT should not be canceled or delayed because of a positive TST result [DIII].

Infection Control Surveillance

HSCT units should not perform routine fungal or bacterial cultures of asymptomatic HSCT recipients (37) [DII]. In the absence of epidemiologic clusters of infections, HSCT units should not perform routine periodic bacterial surveillance cultures of the HSCT unit environment or of equipment or devices used for respiratory therapy, pulmonary-function testing, or delivery of inhalation anesthesia (5) [DIII]. Some experts suggest that hospitals routinely sample air, ceiling tiles, ventilation ducts, and filters to test for molds, especially when construction or renovation occurs near or around the rooms of immunocompromised patients (24,37) or when clinical surveillance demonstrates a possible increase in mold (e.g., aspergillosis) cases [CIII]. In the absence of a nosocomial fungal outbreak, HSCT units need not perform routine fungal cultures of devices and dust in the rooms of HSCT recipients and candidates undergoing conditioning therapy [DIII]. HSCT units should routinely monitor the number of aspergillosis cases occurring in HSCT recipients, especially during hospital construction or renovation [BIII]. A twofold or greater increase in the attack rate of aspergillosis during any 6-month period indicates that the HSCT unit environment should be evaluated for breaks in infection control techniques and procedures and that the ventilation system should be carefully investigated (21) [BIII].

Careful adherence to the recommendations in these Guidelines for the Prevention of Opportunistic Infections in Hematopoietic Stem Cell Transplant Recipients may decrease the rate of hospital infections among HSCT recipients.


The author thanks Richard Besser, John M. Boyce, Raymond Chinn, Harold W. Jaffe, William R. Jarvis, Jonathan E. Kaplan, William Kohn, David L. Longworth, Michael McNeil, Lauren Patton, Doug Peterson, Michele Pearson, Frank Rhame, Renee Ridzon, Kent A. Sepkowitz, Jane D. Siegel, Andrew J. Streifel, Raymond Strikas, Keith Sullivan, Thomas Walsh, and Estella Whimbey for their assistance.

(1) Chair: Clare A. Dykewicz: Members: Raleigh A. Bowden, David Emanuel, David Longworth, Philip A. Rowlings, Robert H. Rubin, Kent A. Sepkowitz, Keith Sullivan, and John R. Wingard. CDC members: Robert T. Chen, Brian R. Edlin, Beth Hibbs, Harold W. Jaffe, William R. Jarvis, Jonathan Kaplan, Thomas J. Spira.


(1.) Dykewicz CA. Preventing opportunistic infections in bone marrow transplant recipients. Transplant Infectious Disease 1999;1:40-9.

(2.) United States Public Health Service United States Public Health Service (USPHS), a major division of the Department of Health and Human Services. The USPHS provides oversight of the following agencies: the Centers for Disease Control and Prevention (CDC); Food and Drug Administration
 (USPHS USPHS United States Public Health Service.

United States Public Health Service
)/Infectious Diseases Society of America (IDSA) Prevention of Opportunistic Infections Working Group. USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus human immunodeficiency virus

Human immunodeficiency virus (HIV)
A transmissible retrovirus that causes AIDS in humans.
: a summary. MMWR MMWR Morbidity & Mortality Weekly Report Epidemiology A news bulletin published by the CDC, which provides epidemiologic data–eg, statistics on the incidence of AIDS, rabies, rubella, STDs and other communicable diseases, causes of mortality–eg,  Morb Mortal Wkly Rep 1995;44(No. RR-8):1-34. Available from: URL URL
 in full Uniform Resource Locator

Address of a resource on the Internet. The resource can be any type of file stored on a server, such as a Web page, a text file, a graphics file, or an application program.
: http://

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(6.) American Institute of Architects The American Institute of Architects (AIA) is a professional organization for architects in the United States. Organized in 1857, the Institute conducts various activities and programs to support the profession and enhance its public image, including periodically awarding the AIA  Academy of Architecture for Health. 1996-1997 Guidelines for design and construction of hospitals and health care facilities. Washington: The Institute; 1996.

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(12.) Storb R, Prentice RL, Buckner CD, Clift RA, Appelbaum F, Deeg J, et al. Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. N Engl J Med 1983;308:302-7.

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(18.) Centers for Disease Control and Prevention. Overview of CDC Guidelines for the Prevention and Control of Nosocomial Infections. Available at URL: http://www/cdc/gov/ncidod/hip/ Guide/overview.htm

(19.) Garner JS, Favero MS. CDC Guidelines for the prevention and control of nosocomial infections. Guideline for handwashing and hospital environmental control, 1985. Supersedes guideline for hospital environmental control published in 1981. Am J Infect Control 1986;14:110-29, or available at URL: ncidod/hip/Guide/handwash.htm

(20.) Rotter ML. Hand washing and hand disinfection disinfection,
n the process of destroying pathogenic organisms or rendering them inert.

disinfection, full oral cavity,
n a procedure used to reduce active periodontal disease, usually completed within a certain short time frame.
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Dr. Dykewicz is a medical epidemiologist in the Division of AIDS, STD (Subscriber Trunk Dialing) Long distance dialing outside of the U.S. that does not require operator intervention. STD prefix codes are required and billing is based on call units, which are a fixed amount of money in the currency of that country. , and TB Laboratory Research, National Center for Infectious Diseases, CDC. She was an officer in the Epidemic Intelligence Service The Epidemic Intelligence Service is a program of the United States' Centers for Disease Control and Prevention. Established in 1951 due to biological warfare concerns arising from the Korean War, it has become a hands-on two-year postgraduate training program in epidemiology, with  from 1989 to 1991 and completed a fellowship in pediatric infectious diseases at Yale University in 1995.

Address for correspondence: Clare A. Dykewicz, Centers for Disease Control and Prevention, 1600 Clifton Rd., N.E., Mailstop A12, Atlanta, GA 30333, USA; fax: 404-639-4664; e-mail:
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Author:Dykewicz, Clare A.
Publication:Emerging Infectious Diseases
Geographic Code:1USA
Date:Mar 1, 2001
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