Halozyme Therapeutics Presents rHuPH20 Hyaluronidase Preclinical Data at the 2005 American Association for Cancer Research; - rHuPH20 Enzyme Increases Tumor Sensitivity to Chemotherapy -.
ANAHEIM, Calif. and SAN DIEGO San Diego (săn dēā`gō), city (1990 pop. 1,110,549), seat of San Diego co., S Calif., on San Diego Bay; inc. 1850. San Diego includes the unincorporated communities of La Jolla and Spring Valley. Coronado is across the bay. , April 19 /PRNewswire-FirstCall/ -- Halozyme Therapeutics Halozyme Therapeutics (AMEX: HTI) is an American international pharmaceutical company based in San Diego, California. They are a developmental and commercial stage biopharmaceutical company. They currently have two products on the market which include Hylenex and Cumulase. , Inc. , a development stage biopharmaceutical company focused on the development and commercialization of recombinant human enzymes, announced today that results from new preclinical studies investigating the use of Halozyme's recombinant human PH20 (rHuPH20) hyaluronidase Hyaluronidase
Any one of a family of enzymes, also known as hyaluronate lyases or spreading factors, produced by mammals, reptiles, insects, and bacteria, which catalyze the breakdown of hyaluronic acid. enzyme in conjunction with chemotherapy were presented today at the American Association for Cancer Research Annual Meeting in Anaheim, California. Studies conducted in collaboration with the University of Trondheim, Norway, showed that rHuPH20 reduced both tumor interstitial fluid interstitial fluid
The fluid in spaces between the tissue cells.
The fluid between cells in tissues. Referred to as the liquid subtance of the body.
Mentioned in: Lymphedema pressure in animal models and the resistance of cultured human bladder carcinoma aggregates to a commonly used chemotherapy agent.
Bladder carcinoma cells were found to become more resistant to chemotherapy when they were grown as multicellular aggregates shaped as spheres (i.e., "spheroids") vs. grown as flat single cell layers, potentially due to the gel-like substance made of hyaluronic acid hyaluronic acid: see mucopolysaccharide.
A polysaccharide which is an integral part of the gel-like substance of animal connective tissue; it supposedly serves as a lubricant and shock absorbent in the joints. (HA) that surrounds the spheroids and acts as a barrier to the dispersion and penetration of chemotherapy into tumors. After the addition of rHuPH20 to the tumor aggregates to remove the HA, investigators demonstrated increased penetration of chemotherapeutic agents and greater cell killing in the treated spheroids vs. controls. The chemosensitivity of the tumor cells increased to the point where they exhibited the same degree of chemosensitivity as the flat single cell layers, which can be potentially attributed to the increased accessibility of tumor cells by chemotherapy once the HA barrier was removed.
"The challenge for chemotherapy to effectively reach the inner core of tumors is often forgotten when studying cells grown in petri dishes," said Gregory Frost, PhD, Halozyme's Vice President and Chief Scientific Officer. "These studies lay the pharmacologic foundation for the development of Chemophase(TM), and generally support the previous positive clinical findings from treating transitional bladder cancer bladder cancer
Malignant tumour of the bladder. The most significant risk factor associated with bladder cancer is smoking. Exposure to chemicals called arylamines, which are used in the leather, rubber, printing, and textiles industries, is another risk factor. patients with animal-sourced hyaluronidase and chemotherapy. We are excited about pursuing the development of a potential new bladder cancer treatment, which we plan to bring into the clinic in the second half of this year, pending appropriate FDA authorization."
Halozyme's rHuPH20 is a highly purified, recombinant form of the naturally occurring human enzyme and is being investigated for its ability to break down hyaluronic acid (HA), the space-filling "gel"-like substance that is a major component of tissues throughout the body. Hyaluronidase injected in the bladder through intravesical administration may temporarily digest the HA gel found around bladder tumor cells to potentially enhance the penetration and diffusion of other administered drugs, such as chemotherapy.
About Halozyme Therapeutics, Inc.
Halozyme is a development stage biopharmaceutical company dedicated to developing and commercializing recombinant human enzymes for the infertility, ophthalmology, and oncology communities. The company's portfolio of products under development is based on intellectual property covering the family of human enzymes known as hyaluronidases. Halozyme's recombinant human enzymes may replace current animal slaughterhouse-derived enzymes that carry potential risks of animal pathogen transmission and immunogenicity immunogenicity /im·mu·no·ge·nic·i·ty/ (-je-nis´it-e) the property enabling a substance to provoke an immune response, or the degree to which a substance possesses this property. . The versatility of the first enzyme, rHuPH20, enables Halozyme to develop the product as a medical device, drug enhancement agent, and therapeutic biologic.
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Halozyme Contact Investor Relations Contacts David A. Ramsay Ina McGuinness / Bruce Voss Chief Financial Officer Lippert/Heilshorn & Associates (858) 794-8889 (310) 691-7100 firstname.lastname@example.org email@example.com Media Contacts Kathy Sweeney / Joleen Schultz Mentus 858-455-5500, x230/x215 firstname.lastname@example.org email@example.com
CONTACT: David A. Ramsay, Chief Financial Officer of Halozyme Therapeutics, Inc., +1-858-794-8889, firstname.lastname@example.org; or Investor Relations Investor relations
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