HIV protease inhibitors vs. malaria.Researchers at San Francisco General Hospital San Francisco General Hospital is the main public hospital in San Francisco, California, and the only Level I Trauma Center serving San Francisco and San Mateo. The hospital budget is for only 302 beds at SFGH. and the Howard Hughes Institute tested seven HIV protease inhibitors in the laboratory and found that all of them have activity against Plasmodium falciparum at concentrations found in patients. The best one in their tests was Kaletra. "These findings suggest that use of HIV-1 protease inhibitors may offer clinically relevant antimalarial antimalarial /an·ti·ma·lar·i·al/ (-mah-lar´e-al) therapeutically effective against malaria, or an agent with this quality. an·ti·ma·lar·i·al adj. Preventing or relieving the symptoms of malaria. activity." Comment: If protease inhibitors that were never designed or optimized for malaria can be active, it should be possible to produce much better anti-malarial drugs in this class. Reference: Parikh S, Gut J, Istvan E, Goldberg DE, Havlier DV, and Rosenthal PJ. Antimalarial activity of human immunodeficiency virus human immunodeficiency virus n. HIV. Human immunodeficiency virus (HIV) A transmissible retrovirus that causes AIDS in humans. type 1 protease inhibitors. Antimicrobial Agents and Chemotherapy Antimicrobial Agents and Chemotherapy (print-ISSN 0066-4804, CODEN AMACCQ; canceled ISSN 0074-9923, canceled CODEN AACHAX) is an academic journal published by the American Society for Microbiology. . July 2005; volume 49, number 7, pages 2983-2985. |
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