Growth hormone therapy in pediatrics; 20 years of KIGS.9783805582568 Growth hormone therapy in pediatrics; 20 years of KIGS. Ed. by Michael B. Ranke et al. S. Karger, AG 2007 519 pages $163.75 Hardcover RC658 Begun in 1987, KIGS (Pfizer International Growth Database) is a pharmacoepidemiological survey project investigating recombinant growth hormone treatment Growth hormone (GH) is a protein hormone secreted by the pituitary gland which stimulates growth and cell reproduction. In the past growth hormone was extracted from human pituitary glands. GH is now produced by recombinant DNA technology, and prescribed for a variety of reasons. in some 60,000 children with short stature in 50 countries around the world. In this work, Ranke (pediatric pediatric /pe·di·at·ric/ (pe?de-at´rik) pertaining to the health of children. pe·di·at·ric adj. Of or relating to pediatrics. oncology, U. Children's Hospital, U of Tubingen, Germany), Price (Royal Manchester Children's Hospital Royal Manchester Children's Hospital was founded in 1829 as a small dispensary based in Salford, Greater Manchester, England for the treatment of sick children. It was the first such hospital in Great Britain and by 1855 had developed to a six-bed hospital. , UK), and Reiter (Baystate Children's Hospital, Tufts U. School of Medicine, US) present 36 papers, some of which review the medical literature relevant to the use of growth hormone treatment and others of which analyze the data from the program's database, frequently pairing related topics from both categories (a few combine the two foci). In the first category one finds such topics as assessment of growth and puberty, the role of insulin-like growth factors insulin-like growth factors (IGF), n a group of polypeptides responsible for the activity of growth hormones, similar in chemical structure to insulin. in growth hormone deficiency growth hormone deficiency Hypopituitarism Endocrinology A condition which affects 1:4000 children; ♂:♀, 3-4:1 Etiology 70% of GHD is idiopathic and attributed to a prenatal insult, possibly due to hypothalamic dysfunction, given that GHD children , characteristics of idiopathic growth hormone deficiency at the start of growth hormone therapy and response to growth hormone, childhood brain tumors and growth hormone treatment, growth hormone treatment of cystic fibrosis, and growth and growth hormone treatment in patients with juvenile idiopathic arthritis
Juvenile idiopathic arthritis (JIA), formerly known as juvenile rheumatoid arthritis (JRA),[1] , and metabolic effects of growth hormone. The second category includes discussions of data analyses within KIGS, the KIGS etiology classification system, the KIGS experience with growth hormone treatment to final height in idiopathic growth hormone deficiency, KIGS patients with acquired growth hormone deficiency, and results of growth hormone treatment of Noonan syndrome in KIGS. ([c]20072005 Book News, Inc., Portland, OR) |
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