Glycogenic acanthosis.A 48-year-old woman presented to the Scripps Center for Voice and Swallowing with complaints of pyrosis pyrosis: see heartburn. , dysphagia dysphagia /dys·pha·gia/ (-fa´jah) difficulty in swallowing. dys·pha·gia or dys·pha·gy n. Difficulty in swallowing or inability to swallow. , excessive throat clearing, nocturnal cough, and intermittent dysphonia dysphonia /dys·pho·nia/ (-fo´ne-ah) a voice impairment or speech disorder.dysphon´ic dys·pho·ni·a n. Difficulty in speaking, usually evidenced by hoarseness. . Direct laryngoscopy revealed moderate laryngeal laryngeal /lar·yn·ge·al/ (lah-rin´je-al) pertaining to the larynx. la·ryn·geal or la·ryn·gal adj. Of, relating to, affecting, or near the larynx. inflammation and bilateral edema edema (ĭdē`mə), abnormal accumulation of fluid in the body tissues or in the body cavities causing swelling or distention of the affected parts. of the ventral surface of the vocal folds (pseudosulcus vocalis) (figure 1). Screening transnasal esophagoscopy revealed benign-appearing white patches as large as 9 mm in diameter throughout the lumen of the proximal and middle esophagus (figure 2). Biopsy analysis revealed hyper-plastic squamous epithelium with increased glycogen content; these findings were consistent with a diagnosis of glycogenic acanthosis. [FIGURES 1-2 OMITTED] Glycogenic acanthosis is a benign condition of the esophagus that is found on as many as 3.5% of esophageal endoscopies. (1) Some investigators have reported that this condition is associated with gastroesophageal reflux. It does not require surveillance. (1) Reference (1.) Vadva MD, Triadafilopoulos G. Glycogenic acanthosis of the esophagus and gastroesophageal reflux. J Clin Gastroenterol Jul 1993;17(1):79-83. From the Scripps Center for Voice and Swallowing, La Jolla, Calif. |
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