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Genome Quebec Innovation Centre Purchases Production-Scale SNP Genotyping Solution From Illumina.


Business Editors & Health/Medical Writers

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SAN DIEGO San Diego (săn dēā`gō), city (1990 pop. 1,110,549), seat of San Diego co., S Calif., on San Diego Bay; inc. 1850. San Diego includes the unincorporated communities of La Jolla and Spring Valley. Coronado is across the bay.  & MONTREAL, QUEBEC--(BUSINESS WIRE)--Jan. 9, 2003

Illumina's BeadArray(TM) Technology Will Underpin Canadian Genotyping

Contribution to the International HapMap Project The International HapMap Project is an organization whose goal is to develop a haplotype map of the human genome (the HapMap), which will describe the common patterns of human genetic variation.  

Illumina, Inc. (Nasdaq: ILMN) announced today an agreement with Genome Quebec for the purchase of Illumina's SNP SNP Scottish National Party

Noun 1. SNP - (genetics) genetic variation in a DNA sequence that occurs when a single nucleotide in a genome is altered; SNPs are usually considered to be point mutations that have been evolutionarily
 genotyping solution. Illumina's solution includes all aspects of a production-scale laboratory and will be an integral component of the new Genome Quebec Innovation Centre, located on the McGill University McGill University, at Montreal, Que., Canada; coeducational; chartered 1821, opened 1829. It was named for James McGill, who left a bequest to establish it. Its real development dates from 1855 when John W. Dawson became principal.  campus in Montreal, Canada.

The genotyping solution will be used to support Canada's contribution to the International HapMap Project as well as genotyping projects for Genome Quebec, Genome Canada, McGill University and other academic institutions in Canada. The Centre, which is also funded by Genome Canada and the Ministry of Finance, Economy and Research (MFER) in Quebec, aims to create and develop world-leading capabilities for genomics and proteomics research.

The genotyping laboratory solution is built around Illumina's proprietary BeadArray(TM) technology and features high sample throughput, unprecedented multiplex levels, LIMS LIMS Laboratory Information Management System
LIMS Library Information Management System
LIMS Limb Infrared Monitor of the Stratosphere
LIMS Land Information Management System (Canada)
LIMS Logistics Information Management System
 (laboratory information management system) control and low running cost per SNP scored. The complete offering is fully integrated to ensure optimal SNP genotyping performance. Included in the turnkey offering are Sherlock(TM) scanning equipment, GoldenGate(TM) assay protocols, LIMS and analytical software Analytical software is software that is designed specifically for and development of a particular environment or object. , fluid-handling robotics, and access to Sentrix(TM) array matrices and reagent supply, along with installation, start-up, training, and support services support services Psychology Non-health care-related ancillary services–eg, transportation, financial aid, support groups, homemaker services, respite services, and other services . When installed, the genotyping laboratory at Genome Quebec Innovation Centre will be able to produce routinely one million genotypes per day, the world's largest throughput of any genotyping system outside of Illumina.

Thomas Hudson Thomas Hudson can refer to:
  • Thomas Hudson (painter), an English portrait painter of the eighteenth century
  • Thomas Hudson (poet), part of the Castalian Band at the court of James VI of Scotland
  • Thomas J. Hudson, a Canadian genome scientist
  • Thomas Hudson, actor
, M.D., principal investigator Noun 1. principal investigator - the scientist in charge of an experiment or research project
PI

scientist - a person with advanced knowledge of one or more sciences
 and head of the Canadian HapMap Project team, commented, "Illumina's system enables a scale of experimentation and cost-effectiveness that is unmatched in the industry and consistent with what we need to execute our HapMap Project deliverables. We'll leverage Illumina's technology to develop over 150,000 assays and provide the Canadian HapMap contribution - ten per cent of the global total. Equally important, the system will support a wide range of additional genotyping applications, such as linkage analysis linkage analysis Genetics A gene-hunting technique that traces patterns of heredity in large, high-risk families, in an attempt to locate a disease-causing gene mutation by identifying traits co-inherited with it; the formal study of the association between the  and fine chromosomal mapping, to help the Canadian genomics community contribute materially to an improved global understanding of genetic variation and function."

Paul L'Archeveque, President and CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Genome Quebec, added, "It is exciting for all of us to be among the first to integrate this leading-edge technology to Genome Quebec Innovation Centre. This is in line with our mission, to create in Quebec within five years, one of the most important centres for genomic and proteomic research in the world."

Jay Flatley, Illumina President and CEO, stated, "We're very pleased that Genome Quebec will use our BeadArray-based system as the core genotyping platform in the new Innovation Centre. As a fellow HapMap Project participant, we look forward to working closely with Tom Hudson, his colleagues, and other international contributors on this seminal post-genome initiative."

Illumina (Nasdaq: ILMN; www.illumina.com) is developing next-generation tools that permit large-scale analysis of genetic variation and function. The Company's proprietary BeadArray(TM) technology provides the throughput, cost effectiveness and flexibility necessary to enable researchers in the life sciences and pharmaceutical industries to perform the billions of tests necessary to extract medically valuable information from advances in genomics and proteomics. This information will help pave the way to personalized medicine.

Genome Quebec is a not-for-profit investment organization created to implement and apply a comprehensive development strategy for the genomics and proteomics research sector in Quebec. Working with universities and many private-sector partners, Genome Quebec's mission is to establish in Quebec one of the world's ten largest research centres in this sector. Quebec, already a recognized leader in biotechnology and pharmaceuticals, must invest in genomics and proteomics if it is to retain its leadership role in these fields and thus continue growing in today's knowledge economy.

"Safe Harbor Safe Harbor

1. A legal provision to reduce or eliminate liability as long as good faith is demonstrated.

2. A form of shark repellent implemented by a target company acquiring a business that is so poorly regulated that the target itself is less attractive.
" Statement under the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995: this release may contain forward-looking statements that involve risks and uncertainties. Among the important factors which could cause actual results to differ materially from those in the forward-looking statements are Illumina's ability to fully develop its BeadArray and Oligator technologies, the Company's ability to successfully build international sales and support organizations to install and service its laboratory facilities at customer locations, the Company's ability to develop and deploy new applications for its platform technology, and other factors detailed in the Company's filings with the Securities and Exchange Commission including its recent filings on Forms 10-K and 10-Q or in information disclosed in public conference calls, the date and time of which are released beforehand. Illumina disclaims any intent or obligation to update these forward-looking statements beyond the date of this release.

Editors' Note

Announced in late October in Washington, DC, the International HapMap Project will speed the discovery of genes related to common illnesses such as asthma, cancer and heart disease. The Project will identify and map blocks of DNA DNA: see nucleic acid.
DNA
 or deoxyribonucleic acid

One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes.
 into which the human genome is organized. These haplotype haplotype /hap·lo·type/ (-tip) the group of alleles of linked genes, e.g., the HLA complex, contributed by either parent; the haploid genetic constitution contributed by either parent.

hap·lo·type
n.
 blocks contain many SNPs (single-letter sequence variations that represent the most common source of genetic variation), only one or two of which need to be identified to know all the SNPs associated with that one block.

Project contributors include research groups representing Canada, China, Japan, Nigeria, the United Kingdom and the United States. Illumina is one of five funded U.S. organizations working on the project. The Company received the largest award of any U.S participant and will be responsible for mapping over 10% of the haplotypes in the genome. Illumina is collaborating with the Wellcome Trust Sanger Institute and the Wellcome Trust Centre for Human Genetics Human genetics

A discipline concerned with genetically determined resemblances and differences among human beings. Technological advances in the visualization of human chromosomes have shown that abnormalities of chromosome number or structure are surprisingly
, Oxford University.

More information on the HapMap Project and its participants at the following addresses: http://www.illumina.com/tech_life_hapmap.htm http://www.genomequebec.com
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Publication:Business Wire
Geographic Code:1CANA
Date:Jan 9, 2003
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