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GeneThera to Advance RNA Interference Work Through Collaboration Agreement.


WHEAT RIDGE, Colo. -- GeneThera, Inc. (OTCBB OTCBB

See OTC Bulletin Board (OTCBB).
:GTHA) is pleased to update its shareholders with this release announcing the continuation of work done earlier by the Company on RNA Interference (RNAi) in its Colorado laboratory.

RNA interference is used to regulate gene expression in the cells of humans. Hundreds of genes in our genome encode small RNA RNA: see nucleic acid.
RNA
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
 molecules called microRNAs. They contain pieces of the code of other genes. Such a microRNA molecule can form a double-stranded structure and activate the RNA interference machinery to block protein synthesis. The expression of that particular gene is silenced. Genetic regulation by microRNAs plays an important role in the development of the organism and the control of cellular functions.

RNAi has already become an important research tool in biology and biomedicine. In the future, it is hoped that it will be used in many disciplines including clinical medicine and agriculture. Several recent publications show successful gene silencing in human cells and experimental animals. For instance, a gene causing high blood cholesterol levels was recently shown to be silenced by treating animals with silencing RNA. Plans are underway to develop silencing RNA as a treatment for virus infections, cardiovascular diseases, cancer, endocrine disorders and several other conditions.

"With the collaboration agreement in place with IZSLER, GeneThera can now advance our previous research work to the next stage with our access to experimentally infected cattle," said Dr. Tony Milici, CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of GeneThera. "We had received some promising results on some specific cell lines using RNAi but were unable to continue the research until infected cattle were available".

"With a Nobel prize being issued this year to two highly respected scientists for their discovery and research on RNAi, we feel that it is of great importance for the regulation of gene expression Gene modulation redirects here. For information on therapeutic regulation of gene expression, see therapeutic gene modulation.
For vocabulary, see Glossary of gene expression terms


.
 and it may lead to advances in vaccine programs for both animals and humans. Large pharmaceutical companies are beginning to understand the importance of RNAi as evidenced by Merck's recent purchase of Sirna Therapeutics and GeneThera hopes to further its use of RNAi as a discovery tool in our TSE See Tokyo Stock Exchange.

TSE

1. See Tokyo Stock Exchange (TSE).

2. See Toronto Stock Exchange (TSE).
 studies as well."

About GeneThera, Inc.

GeneThera, Inc. is a molecular biotechnology company located in Wheat Ridge, CO. The Company provides genetic diagnostic solutions for the veterinary and agricultural industries with future plans to include the health-care industry. The Company's proprietary diagnostic solution is based on a genetic expression assay, GEA[TM], a protocol designed to function on a highly automated Fluorogenic PCR PCR polymerase chain reaction.

PCR
abbr.
polymerase chain reaction


Polymerase chain reaction (PCR) 
 platform. This platform enables GeneThera to offer tests that are presently not available from other technologies. The GEA[TM] is designed for a host of individual diseases, the current priority being Mad Cow disease mad cow disease: see prion.
mad cow disease
 or bovine spongiform encephalopathy (BSE)

Fatal neurodegenerative disease of cattle. Symptoms include behavioral changes (e.g.
, Chronic Wasting Disease Noun 1. chronic wasting disease - a wildlife disease (akin to bovine spongiform encephalitis) that affects deer and elk
animal disease - a disease that typically does not affect human beings
, a disease affecting elk and deer in North America; E.Coli 0157:H7 and Johnne's Disease, which are diseases affecting cattle worldwide.

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"Safe Harbor" Statement: Certain statements in this release are "forward-looking" statements as defined in the Private Securities Litigation Reform Act The Private Securities Litigation Reform Act of 1995 (PSLRA) implemented several significant substantive changes affecting certain cases brought under the federal securities laws, including changes related to pleading, discovery, liability, class representation and awards fees and  of 1995. Such statements are subject to numerous risks and uncertainties. Actual results may vary significantly from the results expressed or implied in such statements. Factors that could cause actual results to materially differ from forward-looking statements include, but are not limited to, the Company's ability to meet the terms and conditions required to obtain its project financing, risks and delays associated with product development, risk of market acceptance of new products, risk of technology or product obsolescence ob·so·les·cent  
adj.
1. Being in the process of passing out of use or usefulness; becoming obsolete.

2. Biology Gradually disappearing; imperfectly or only slightly developed.
, competitive risks, reliance on development partners and the need for additional capital.
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Publication:Business Wire
Date:Nov 8, 2006
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