Gene expression helps classify cancers.Only about 60 percent of people with diffuse large B-cell lymphoma diffuse large B-cell lymphoma Oncology A B-cell lymphoma that is the most common type–accounting for 30-40%–of NHL, which occurs in children and adults. See Lymphoma, Non-Hodgkin's lymphoma, WHO classification. , a common cancer of white blood cells White blood cellsA group of several cell types that occur in the bloodstream and are essential for a properly functioning immune system. Mentioned in: Abscess Incision & Drainage, Bone Marrow Transplantation, Complement Deficiencies , respond well to therapy. This cancer, as currently defined, is in fact two distinct diseases, according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. new tests that use so-called gene chips to look at the activity of thousands of genes simultaneously. Patients with one pattern of gene expression, called germinal-center B-like pattern, seem to respond better to treatment than the other patients do, says R. Eric Davis Eric Davis may refer to:
Among 19 people with germinal-center B-like disease, 14 were still alive 5 years after diagnosis, he and his colleagues report in the Feb. 3 NATURE. In contrast, only 3 of 19 patients with so-called activated B-like disease survived for 5 years. The team hopes that gene chips will illuminate the cellular pathways that give rise to the slightly different cancers and those results will lead to more successful therapies. |
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