GSK-3 as a Drug Target in Treating Disorders like Alzheimer's and Mood Disorders and the Development of GSK-3 Inhibitors.DUBLIN, Ireland -- Research and Markets (http://www.researchandmarkets.com/reports/c42218) has announced the addition of Glycogen Synthase synthase /syn·thase/ (-thas) a term used in the names of some enzymes, particularly lyases, when the synthetic aspect of the reaction is dominant or emphasized. syn·thase n. Kinase-3 (GSK-3) and Its Inhibitors: Drug Discovery and Development to their offering. This book gathers and systematically analyzes relevant up-to-date information concerning GSK-3 and its known inhibitors. Such a text is very useful to researchers interested in drug design and development, especially those directly involved in the fascinating world of GSK-3. Included in the book are chapters on: GSK-3 basics like cell biology and crystal structure; more advanced topics such as GSK-3 and stem cells stem cells, unspecialized human or animal cells that can produce mature specialized body cells and at the same time replicate themselves. Embryonic stem cells are derived from a blastocyst (the blastula typical of placental mammals; see embryo), which is very young ; GSK-3 as a drug target in treating disorders like Alzheimer's and mood disorders; and the development of GSK-3 inhibitors with assays and animal models. Content Titles Include: SECTION A: CELLULAR FUNCTIONS OF GSK-3. Chapter 1. Glycogen Synthase glycogen synthase n. An enzyme that catalyzes the transfer of glucose from UDP-glucose to glycogen. Kinase-3 an Introductory Synopsis Chapter 2. Glycogen-Synthase-Kinase- (GSK-3(2)) a Key Signaling Enzyme: A Developmental Neurobiological neu·ro·bi·ol·o·gy n. The biological study of the nervous system or any part of it. neu  ro·bi Perspective. Chapter 3. Role of GSK GSK GlaxoSmithKline plc (pharmaceutical company) GSK Glycogen Synthase Kinase GSK Gruppentraining Sozialer Kompetenzen (Germany) GSK Greenland Shark (FAO fish species code) 3/Shaggy in neuronal cell biology. Chapter 4. The Crystal Structures of Glycogen Synthase Kinase 3. Chapter 5. Kinase-Kinase and Site-Site Interactions in the Phosphorylation phosphorylation, chemical process in which a phosphate group is added to an organic molecule. In living cells phosphorylation is associated with respiration, which takes place in the cell's mitochondria, and photosynthesis, which takes place in the chloroplasts. of Tau by GSK-3. SECTION B: GSK3 AS A THERAPEUTIC TARGET IN HUMAN PATHOLOGY. Chapter 6. GSK-3, a Key Player in Alzheimers Disease. Chapter 7. Glycogen Synthase Kinase-3: A Target for Novel Mood Disorder mood disorder n. Any of a group of psychiatric disorders, including depression and bipolar disorder, characterized by a pervasive disturbance of mood that is not caused by an organic abnormality. Also called affective disorder. Treatments. Chapter 8. GSK3 and Stem Cells. Chapter 9. Glycogen synthase kinase-3: role in neurodegeneration and neuroprotection. Chapter 10. Protein Kinase Inhibitors. Assay Development. Chapter 11. Animal Models with Modified Expression of GSK-3 for the Study of Its Physiology and of Its Implications in Human Pathologies. Chapter 12. Lithium, the Seminal GSK3 Inhibitor. SECTION C: GSK-3 INHIBITORS: DEVELOPMENT AND THERAPEUTIC POTENTIAL. Chapter 13. Inhibition of GSK3 as Therapeutic Strategy in Disease: Efficacy of AR-A014418. Chapter 14. TDZDs: Selective and ATP ATP: see adenosine triphosphate. ATP in full adenosine triphosphate Organic compound, substrate in many enzyme-catalyzed reactions (see catalysis) in the cells of animals, plants, and microorganisms. Non Competitive Glycogen Synthase Kinase-3 Inhibitors. Chapter 15. 3-Amino Pyrazoles as Potent and Selective Glycogen Synthase (GSK-3) Inhibitors. Chapter 16. Marine compounds as a new source for Glycogen Synthase Kinase-3 Inhibitors. GSK-3 is a promising drug target that has been extensively tested, and shown great potential for treatment of diseases that have no current effective treatment like Alzheimers, bipolar disorder bipolar disorder, formerly manic-depressive disorder or manic-depression, severe mental disorder involving manic episodes that are usually accompanied by episodes of depression. , and cancer. GSK-3 and Its Inhibitors gathers and systematically analyzes a collection of studies and information in a single source and tool for biochemists and cell biologists. For more information visit http://www.researchandmarkets.com/reports/c42218 |
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