GPC BIOTECH GETS U.S. PATENT FOR ANTI-CANCER CELL INHIBITOR.GPC Biotech AG (Frankfurt Stock Exchange Frankfurt Stock Exchange
The largest of Germany's eight securities exchanges, operated by Deutsche Borse AS. : GPC (1) A PC that uses the Linux-based gOS operating system. See gOS.
(2) (GPC Group) Originally the Graphics Performance Characterization committee of the NCGA, the GPC Group is now part of Standard Performance Evaluation Corporation (SPEC) and oversees the following ; TecDAX 30) has announced that the U.S. Patent and Trademark Office has issued a patent with claims covering RGB-286199, cell cycle inhibitor, to GPC Biotech.
The patent (U.S. Patent No. 6,753,329) claims the composition of matter of a family of cell cycle inhibitors that includes RGB-286199. Claims also include pharmaceutical compositions (the compound as a medicinal product medicinal product,
n a substance administered to humans or animals through injection, application, oral ingestion, inhalation, and so forth, whose purpose is to ultimately restore health or eliminate disease in an individual. ), as well as methods of treating certain diseases, including cancer. The basic term of the patent will expire in late 2022. International equivalents of this patent are pending in other major markets, including Europe, Japan and Canada.
"GPC Biotech has extensive expertise in the cell cycle field, and the issuance of this patent strengthens our position in this family of small molecule compounds that may be important in the area of cell cycle control and anti-cancer drug development," said Sebastian Meier-Ewert, Ph.D., chief scientific officer. "Our cell cycle inhibitor, RGB-286199, has made solid progress over the past year, and our goal is to complete pre-clinical development work on this compound in the first half of 2005."
About RGB-286199 cell cycle inhibitor
The cell cycle is a key cellular process that fails to function normally in cancer development. Cyclin-dependent kinases (Cdks) are proteins that are involved in the regulation of the cell cycle. At least four different Cdks control various key events during the cell cycle. RGB-286199 is a potent inhibitor of all of these Cdks, inhibiting cell division and inducing cell death in cancer cells. The compound has also been shown to inhibit other kinases that have been associated with the development of cancer. Anticancer activity of RGB-286199 has been demonstrated in animal models of ovarian, prostate and colon cancer colon cancer, cancer of any part of the colon (often called the large intestine). Colon cancer is the second most common cancer diagnosed in the United States. .
GPC Biotech is currently planning additional toxicology studies, as well as studies to determine appropriate dosing and administration schedules. The company's goal is to complete pre-clinical development work on RGB-286199 in the first half of 2005 and, if successful, GPC Biotech anticipates advancing the drug candidate into clinical trials thereafter.
GPC Biotech AG is a biotechnology company discovering and developing new anticancer drugs Anticancer Drugs Definition
Anticancer, or antineoplastic, drugs are used to treat malignancies, or cancerous growths. Drug therapy may be used alone, or in combination with other treatments such as surgery or radiation therapy. . The company's lead product candidate - satraplatin - is currently in a Phase 3 registrational trial as a second-line chemotherapy second-line chemotherapy Oncology Any chemotherapeutic administered after the agent of choice fails treatment in hormone-refractory prostate cancer prostate cancer, cancer originating in the prostate gland. Prostate cancer is the leading malignancy in men in the United States and is second only to lung cancer as a cause of cancer death in men. primarily in the U.S. and Europe, following successful completion of a Special Protocol Assessment by the U.S. FDA FDA
Food and Drug Administration
n.pr See Food and Drug Administration.
n.pr the abbreviation for the Food and Drug Administration. and receipt of a Scientific Advice letter from the European regulatory authority, EMEA (Europe, Middle East, Africa) Refers to that region of the world. For example, one might see products packaged differently for the UK, EMEA and Asia Pacific markets. . The FDA has also granted fast track designation to satraplatin for this indication. Satraplatin was in-licensed from Spectrum Pharmaceuticals, Inc. Other anticancer programs in development include a monoclonal antibody and a cell cycle inhibitor. The company is leveraging its drug discovery technologies to elucidate the mechanisms-of-action of drug candidates and to support the growth of its drug pipeline. The company has formed successful alliances with a number of pharmaceutical and biotechnology firms. For example, the company has a multi-year alliance with ALTANA Pharma AG to establish the ALTANA Research Institute in the U.S., which provides GPC Biotech with revenues until 2007. GPC Biotech AG is headquartered in Martinsried/Munich (Germany). The company's wholly owned U.S. subsidiary has research sites in Waltham, Massachusetts and Princeton, New Jersey
Princeton, New Jersey is located in Mercer County, New Jersey, United States. Princeton University has been sited in the town since 1756. .
For additional information, visit http://www.gpc-biotech.com or call 781/890 9007, ext. 267.