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GENMAB/ROCHE ANNOUNCE BROAD ANTIBODY DEVELOPMENT COLLABORATION.


Genmab A/S (CSE (Certified Systems Engineer) See Microsoft certification. : GEN and Neuer Markt: GE9D), Copenhagen, Denmark, has announced a broad collaboration with Roche for the creation and development of human antibody therapeutic products for life threatening and debilitating de·bil·i·tat·ing
adj.
Causing a loss of strength or energy.


Debilitating
Weakening, or reducing the strength of.

Mentioned in: Stress Reduction
 diseases. Roche will have access to Genmab's antibody development capabilities, as well as its pre-clinical and clinical development capabilities. Under the terms of the agreement, Genmab expects to receive milestones as well as royalty payments on successful products. In certain circumstances CIRCUMSTANCES, evidence. The particulars which accompany a fact.
     2. The facts proved are either possible or impossible, ordinary and probable, or extraordinary and improbable, recent or ancient; they may have happened near us, or afar off; they are public or
, Genmab could obtain rights to develop products based on disease targets identified by Roche.

Using the UltiMAb(tm) human antibody platform, Genmab's research team, led by Chief Scientific Officer Jan van de Winkel, Ph.D., will create novel human antibodies to disease targets identified by Roche. Dr. van de Winkel, and his team will also employ Genmab's extensive array of pre-clinical assays, including both laboratory and animal models, to assist in the pre-clinical development Pre-clinical development is a stage in the development of a new drug that begins before clinical trials (testing in humans) can begin, and during which important safety and pharmacology data is collected.  of the antibody products. The first three targets have already been identified and these projects will proceed under the direction of a joint Roche-Genmab Research Committee.

"This agreement with Roche is based on the combination of our world class organization and our state of the art human antibody technology, " said Lisa N. Drakeman, Ph.D., Chief Executive Officer of Genmab. "We are excited to work together with Roche and believe this collaboration is valuable to Genmab in a number of areas, including the potential for both future revenues and expanding our product portfolio."

"In several of the disease areas which are in the focus of our research we are working on targets appropriate for antibody therapy antibody therapy Clinical immunology Any therapeutic intervention in which a monoclonal or other concentrated antibody is used to manage a condition–eg, cancer or severe infection . Genmab with its broad experience in the development of human antibodies is therefore an ideal partner for us," said Prof. Klaus Strein, Head of Pharmaceutical Research Penzberg, Roche.

Genmab A/S is a biotechnology company that creates and develops fully human antibodies for the treatment of life-threatening and debilitating diseases. Genmab has four products in development to treat cancer, rheumatoid arthritis rheumatoid arthritis

Chronic, progressive autoimmune disease causing connective-tissue inflammation, mostly in synovial joints. It can occur at any age, is more common in women, and has an unpredictable course.
 and other inflammatory conditions, and intends to assemble a broad portfolio of new therapeutic products arising from research into the human genome The human genome is the genome of Homo sapiens, which is composed of 24 distinct pairs of chromosomes (22 autosomal + X + Y) with a total of approximately 3 billion DNA base pairs containing an estimated 20,000–25,000 genes. . At present, Genmab's commercial opportunities are based upon research conducted at leading international companies, including Immunex Corporation, Oxford GlycoSciences Ltd., Gemini Genomics plc, Eos Biotechnology Inc., and Glaucus Proteomics pro·te·o·mics
n.
The analysis of the expression, localization, functions, and interactions of the proteins produced by the genes of an organism.
 B.V., as well as in its own laboratories. A broad alliance provides Genmab with access to Medarex Inc.'s array of proprietary technologies, including the UltiMAb(tm) platform for the rapid creation and development of fully human antibodies to virtually any disease target.

For more information, visit http://www.genmab.com or call 212.699.2658.
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Comment:GENMAB/ROCHE ANNOUNCE BROAD ANTIBODY DEVELOPMENT COLLABORATION.
Publication:Worldwide Biotech
Geographic Code:4EUDE
Date:Jun 1, 2001
Words:433
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