GENENTECH DISCONTINUES PURSUIT OF ACTIMMUNE FOR RENAL CELL CARCINOMA -- Phase III data analysis shows lack of demonstrable benefit --.SOUTH SAN FRANCISCO South San Francisco, city (1990 pop. 54,312), San Mateo co., W Calif.; inc. 1908. South San Francisco has several industrial parks; its manufactures include medical supplies and equipment, foods, paint, paper products, consumer goods, and clothing. , Calif.--(BUSINESS WIRE)--June 7, 1996--Genentech, Inc. (NYSE NYSE See: New York Stock Exchange :GNE) today announced that it has discontinued pursuing Actimmune(R) (Interferon gamma-1b) for renal cell carcinoma renal cell carcinoma or hypernephroma Malignant tumour of the cells that cover and line the kidney. It usually affects persons over age 50 who have vascular disorders of the kidneys. It seldom causes pain, unless it is advanced. because analysis of Phase III clinical data showed no significant benefit of the product for this targeted indication. Data were analyzed from two Phase III trials: an open-label, non-randomized U.S. study and a randomized, double-blinded, placebo-controlled Canadian study. The overall response rate was similar in both studies. The placebo-controlled Canadian trial demonstrated no statistically significant difference in response rate, response duration, time to progression, or survival between the placebo group and patients receiving Actimmune. Actimmune is currently marketed in the United States for the treatment of chronic granulomatous disease Chronic Granulomatous Disease Definition Chronic granulomatous disease (CGD) is an inherited disorder in which white blood cells lose their ability to destroy certain bacteria and fungi. (CGD CGD Chronic granulomatous disease, see there ). These findings do not change the current treatment recommendations for patients with CGD. Genentech, Inc. is a leading biotechnology company that discovers, develops, manufactures and markets human pharmaceuticals for significant unmet medical needs. The company has headquarters in South San Francisco, California South San Francisco is a city in San Mateo County, California, United States, located on the San Francisco Peninsula in the San Francisco Bay Area. The population was 60,552 at the 2000 census. , and is traded on the New York and Pacific Stock Exchanges under the symbol GNE. CONTACT: Genentech, Inc. Kathleen Rinehart, 415/225-8681 (Media Contact) Laura Leber, 415/225-5759 (Media Contact) Diane Schrick, 415/225-1599 (Investor Contact) GNE Website Address: http://www.gene.com |
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