Four antiretrovirals reduced to three after 48 weeks.A trial started over 400 antiretroviral antiretroviral /an·ti·ret·ro·vi·ral/ (-ret´ro-vi?ral) effective against retroviruses, or an agent with this quality. an·ti·ret·ro·vi·ral (  n-naive patients on an intensive 4-drug regimen--Trizivir, (AZT AZT - Azido-Thymidine (AIDS drug)AZT - Aschheim-Zondek Test, 3TC, and abacavir abacavir /abac·a·vir/ (ah-bak´ah-vir) a nonnucleoside reverse transcriptase inhibitor used as the sulfate salt as an antiretroviral in the treatment of human immunodeficiency virus infection.) together with Sustiva (efavirenz efavirenz /ef·a·vi·renz/ (ef´ah-vi?renz) an antiretroviral, inhibiting reverse transcriptase; used in the treatment of HIV infection. e·fa·vir·enz (  -fä). After 48 weeks, 282 of them were randomized to either continue that regimen, or to drop the Sustiva, for another 48 weeks in the study. "After induction with ABC/3TC/ZDV + EFV EFV - Electric-Field-Variant FunctionEFV - Enhanced Fixed Variable (rate) EFV - Expeditionary Fighting Vehicle, simplification to ABC/3TC/ZDV alone maintained virologic control and immunologic response, reduced fasting lipids and ART-associated adverse events, and improved adherence" (quoted from abstract). There were more virologic failures in the group that dropped the Sustiva and switched to three drugs (16 vs. 8), but this difference did not reach statistical significance (P = 0.134). Markowitz Markowitz - The author of the original Simscript language. M, Hill-Zabala C, Lang J, and others, for the ESS40013 study team. Induction With Abacavir/Lamivudine lamivudine /la·miv·u·dine/ (lah-miv´u-den) a nucleoside analogue that inhibits reverse transcriptase, used as an antiviral agent in the treatment of chronic hepatitis B and, in combination with zidovudine, the treatment of HIV infection and AIDS. la·miv·u·dine /Zidovudine Plus Efavirenz for 48 Weeks Followed by 48-Week Maintenance With Abacavir/Lamivudine/Zidovudine Alone in Antiretroviral-Naive HIV-l-Infected Patients. JAIDS JAIDS - Journal of Acquired Immune Deficiency Syndromes (Journal of Acquired Immune Deficiency immune deficiency n. Syndromes). July 1, 3005; volume 39, number 3, pages 257-264.
See immunodeficiency. |
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