Four antiretrovirals reduced to three after 48 weeks.A trial started over 400 antiretroviral-naive patients on an intensive 4-drug regimen--Trizivir, (AZT AZT or zidovudine (zīdō`vy  dēn'), drug used to treat patients infected with the human immunodeficiency virus (HIV), which causes AIDS; also called , 3TC, and abacavir) together with Sustiva (efavirenz efavirenz /ef·a·vi·renz/ (ef´ah-vi?renz) an antiretroviral, inhibiting reverse transcriptase; used in the treatment of HIV infection. e·fa·vir·enz n. ). After 48 weeks, 282 of them were randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. to either continue that regimen, or to drop the Sustiva, for another 48 weeks in the study. "After induction with ABC/3TC/ZDV + EFV EFV Expeditionary Fighting Vehicle EFV Electronic Viewfinder EFV Enhanced Fixed Variable (rate) EFV Electric-Field-Variant Function , simplification to ABC/3TC/ZDV alone maintained virologic control and immunologic response, reduced fasting lipids and ART-associated adverse events, and improved adherence" (quoted from abstract). There were more virologic failures in the group that dropped the Sustiva and switched to three drugs (16 vs. 8), but this difference did not reach statistical significance (P = 0.134). Markowitz M, Hill-Zabala C, Lang J, and others, for the ESS40013 study team. Induction With Abacavir/Lamivudine/Zidovudine Plus Efavirenz for 48 Weeks Followed by 48-Week Maintenance With Abacavir/Lamivudine/Zidovudine Alone in Antiretroviral-Naive HIV-l-Infected Patients. JAIDS JAIDS Journal of Acquired Immune Deficiency Syndromes (Journal of Acquired Immune Deficiency Syndromes). July 1, 3005; volume 39, number 3, pages 257-264. |
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