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Forbes Medi-Tech Attracts Leading Cardiologist from Cleveland Clinic & Completes Equity Financing of US$10.75 Million.


Business Editors

VANCOUVER, British Columbia--(BUSINESS WIRE)--Jan. 7, 2004

Forbes Appoints Dr. Eric Topol from Cleveland Clinic as Chairman

of the Medical & Scientific Advisory Board and Scientific Consultant

Forbes Medi-Tech Inc. (NASDAQ NASDAQ
 in full National Association of Securities Dealers Automated Quotations

U.S. market for over-the-counter securities. Established in 1971 by the National Association of Securities Dealers (NASD), NASDAQ is an automated quotation system that reports on
:FMTI FMTI Forbes Medi-Tech Inc. (Vancouver, BC) )(TSX TSX Toronto Stock Exchange (TSE before April, 2002)
TSX Transfer from Stack Pointer to Index
TSX True Space Extension
:FMI FMI Fondo Monetario Internacional (Spanish: International Monetary Fund)
FMI Fonds Monétaire International
FMI For More Information
FMI Food Marketing Institute
FMI Fundo Monetário Internacional
) announced today it has raised US$10.75 million by Private Placement, resulting in the issuance of 5.375 million series A voting convertible preferred shares at a price of US$2.00 per share, with approximately 1.61 million warrants attached. Each preferred share is convertible without further consideration at any time at the option of the holder into 1 common share and each warrant entitles the holder to purchase one common share of the Company at US$2.40 for 3 years from the date of closing. Placement proceeds will be used to fund continued research on FM-VP4, further development of the FM-VPx library of compounds and for operational purposes.

Additionally, Dr. Eric Topol has been appointed Chairman of Forbes' Medical & Scientific Advisory Board and Scientific Consultant for its pharmaceutical development program. Dr. Topol is Provost, Cleveland Clinic Lerner College of Medicine The Cleveland Clinic Lerner College of Medicine (CCLCM) was established in 2004 through a collaboration of the Cleveland Clinic and Case Western Reserve University.

CCLCM is a 5-year program with the goal of training physician-scientists.
 and Chief Academic Officer of the Cleveland Clinic Foundation. He is also Chairman of the Department of Cardiovascular Medicine and Professor of Medicine. With the appointment of Dr. Topol, Dr. Jiri Frohlich will continue as a member of Forbes' Medical & Scientific Advisory Board. Forbes extends its gratitude to Dr. Frohlich for his contributions as chairman towards the Company's pharmaceutical development program.

"The culmination of financing and the addition of one of the world's leading cardiologists to Forbes' Medical & Scientific Advisory Board is a strong endorsement of the prospects for our portfolio of cardiovascular compounds," said Charles Butt, President & CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  of Forbes Medi-Tech Inc. "Dr. Topol's extensive background in cardiovascular research will be a tremendous asset in the clinical development program for FM-VP4 while the proceeds from this financing represents substantial support for further research and clinical programs."

Dr. Topol's initial responsibility will be to provide direction for Forbes' clinical development plans, selection of sites and the design of clinical studies for US FDA FDA
abbr.
Food and Drug Administration


FDA,
n.pr See Food and Drug Administration.

FDA,
n.pr the abbreviation for the Food and Drug Administration.
 clinical trials pending the results of the Phase II trials currently underway in Europe.

"I am very impressed with the information to date on FM-VP4 and the Company's Library of Compounds", said Dr. Topol. "The Company's portfolio of compounds represents a substantial opportunity beyond cholesterol reduction. I am excited to be part of such a robust development program towards the treatment of cardiovascular and related diseases."

Investors in the private placement include Great Point Partners, LLC (Logical Link Control) See "LANs" under data link protocol.

LLC - Logical Link Control
 of Greenwich, Connecticut and Biotechnology Development Fund IV, L.P. (BDF IV) of Palo Alto, California “Palo Alto” redirects here. For other uses, see Palo Alto (disambiguation).
Palo Alto (IPA: /ˌpæloʊˈʔæltoʊ/, from Spanish: palo: "stick" and alto: "high", i.e.
. This is the second investment from BDF IV in Forbes in the past four months. The Fund previously participated in a US$4.8 million private placement completed at US$1.485 per share in September of 2003. The cash commission payable on the current transaction is US$277,500.

"Forbes Medi-Tech is developing FM-VP4 for cardiovascular and related diseases, an area for large potential growth," said Dr. Jeffrey Jay, a Great Point Partners Managing Director. "Cardiovascular disease, including the treatment for elevated cholesterol, is currently the largest category in the pharmaceutical industry with approximately $30 billion in sales in 2002; FM-VP4 is in Phase II studies and has the potential to be a major therapeutic in this category," added David Kroin, also a Managing Director of Great Point Partners.

About Dr. Topol

Dr. Eric J. Topol has been elected to the American Association of Physicians and American Society of Clinical Investigation. He is a Fellow, American Heart Association American Heart Association (AHA),
n.pr a national voluntary health agency that has the goal of increasing public and medical awareness of cardiovascular diseases and stroke, and thereby reducing the number of associated deaths and disabilities.
; Fellow, American College of Cardiology The American College of Cardiology (ACC) is a nonprofit medical association established in 1949 to educate, research and influence health care public policy. The president for the 2006–2007 year is Steven E. Nissen. [1] The organization has 39 chapters in the U.S. ; Fellow, American College of Physicians The American College of Physicians (ACP) is a national organization of doctors of internal medicine (internists), physicians who specialize in the prevention, detection and treatment of illnesses in adults. ; Fellow, European Society of Cardiology The European Society of Cardiology (ESC) represents more than 50,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the impact of cardiovascular disease in Europe. ; Fellow and Trustee, Society of Cardiac Angiography and Interventions and Fellow, American College of Chest Physicians The American College of Chest Physicians (ACCP) is a medical organization consisting of physicians and non-physician specialists in the field of chest medicine, which includes pulmonology, thoracic surgery, and critical care medicine. . The program he directs in Cleveland in cardiology has been ranked Number 1 by U.S. News & World Report U.S. News & World Report

Weekly newsmagazine published in Washington, D.C. U.S. News was founded in 1933 by David Lawrence (1888–1973) to cover important domestic events; he founded World Report in 1945 to treat world news. The two magazines were merged in 1948.
 for the past 9 years.

Dr. Topol has served as a principal investigator for more than 15 international multi-center research trials, including GUSTO I-V, EPIC, EPILOG, EPISTENT, PURSUIT, CAVEAT, TARGET, REPLACE and many others, with cumulatively more than 200,000 patients enrolled. He was the first physician ever to administer recombinant t-PA and 2 different platelet glycoprotein IIb/IIIa inhibitors In medicine, a glycoprotein IIb/IIIa inhibitors, also GpIIb/IIIa inhibitors, is class of antiplatelet agents.

Several GpIIb/IIIa inhibitors exist:
  • abciximab (ReoPro®)
  • eptifibatide (Integrilin®)
  • tirofiban (Aggrastat®
 to patients. He has led the clinical development programs of t-PA, abciximab (ReoPro), eptifibatide (Integrilin), bivalirudin (Angiomax) and clopidogrel (Plavix). The results of these large programs, involving 40 countries around the world, have substantially changed the Clinic's approach to patients with coronary artery disease coronary artery disease, condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. . He and his colleagues at Cleveland Clinic recently reported the first gene to induce heart attacks and coronary disease (a MEF2A deletion mutation; Science, 2003).

Currently he serves on the editorial board for over 30 peer review medical publications including Circulation, Circulation Research, JACC JACC Journal of the American College of Cardiology
JACC Java Authorization Contract for Containers
JACC Joint Automatic Control Conference
JACC Journal Access Core Collection
JACC Joint Ambulatory Care Clinic
JACC joint airspace control center
, AJC, British and the European Heart Journals. He has over 850 original publications and has edited 16 books, including the Textbook of Interventional Cardiology (1st - 4th editions) and the Textbook of Cardiovascular Medicine (now in its second edition).

About Great Point Partners, LLC

Great Point Partners LLC of Greenwich, Connecticut (203-552-5353) manages the Biomedical Value Fund, L.P., a bottom-up, primary research oriented, investment fund which is focusing on publicly traded life sciences, medical technology and other healthcare companies. The Fund's investment objective is to generate superior investment returns by financing growth companies through PIPE (Private Investment in a Public Entity) financings, and in other directly negotiated investments.

About Biotechnology Development Fund IV, L.P.

Biotechnology Development Fund IV, L.P. is managed by BioAsia Investments, a Palo Alto, California-based venture firm formed in 1997 for the purpose of investing in private and public life sciences companies primarily in North America. BioAsia makes investment decisions for the Funds and, in addition, helps its portfolio companies to develop corporate strategy, recruit key management personnel, and acquire new products and technology to accelerate growth. BioAsia focuses on investments in companies with clinically proven products in development for unmet medical needs. Additional information on BioAsia can be found on the internet at www.bioasia.com.

About Forbes Medi-Tech Inc.

Forbes Medi-Tech Inc. is a biopharmaceutical company dedicated to the research, development and commercialization of innovative prescription pharmaceutical and nutraceutical products for the prevention and treatment of cardiovascular and related diseases. Forbes' scientific platform is based on core sterol Sterol

Any of a group of naturally occurring or synthetic organic compounds with a steroid ring structure, having a hydroxyl (—OH) group, usually attached to carbon-3.
 technology. By extracting plant sterols sterols (ster´ôlz),
n.pl steroids having one or more hydroxyl groups and no carbonyl or carboxyl groups (e.g., cholesterol).
 from by-products of the forestry industry, Forbes has developed cholesterol-lowering agents for use in pharmaceutical compounds, functional foods and dietary supplements.

This News Release contains forward-looking statements about the Company's future research and development plans, potential pharmaceutical products, future clinical trials, and other information in future periods, which statements can be identified by the use of forward-looking terminology such as "prospects", "further", "potential", "towards", "to provide", " opportunity", "growth", "will be", "is developing", "further", or the negative thereof or any other variations thereon or comparable terminology referring to future dates, events or results. Forward-looking statements are statements about the future and are inherently uncertain, and the Company's actual results could differ materially from those anticipated in those forward-looking statements as a result of numerous factors, including without limitation, uncertainty as to whether FM-VP4 or any other compound will be developed and marketed successfully or at all; the need for further clinical trials, and uncertainty as to their timing and outcome; research and development risks; the risk of technical obsolescence ob·so·les·cent  
adj.
1. Being in the process of passing out of use or usefulness; becoming obsolete.

2. Biology Gradually disappearing; imperfectly or only slightly developed.
; product liability risks; insurance risks; the need for government approvals; manufacturing risks; partnership/strategic alliance risks; the effect of competition; the risk of adverse side effects; intellectual property risks; as well as a description of other risks and uncertainties affecting the Company and its business, as contained in news releases and filings with the United States Securities and Exchange Commission and Canadian Securities Regulatory Authorities, any of which could cause actual results to vary materially from current results or the Company's anticipated future results. Forward-looking statements are based on the beliefs, opinions and expectations of the Company's management at the time they are made, and the Company does not assume any obligation to update its forward-looking statement if those beliefs, opinions or expectations, or other circumstances should change. Information contained in this news release regarding third parties has been provided by the third parties and is not guaranteed by the Company as to accuracy or completeness.

NASDAQ and the Toronto Stock Exchange Toronto Stock Exchange (TSE)

Canada's largest stock exchange, trading approximately 1,200 company stocks and 33 options.
 have not reviewed and do not accept responsibility for the adequacy or accuracy of the content of this News Release.
COPYRIGHT 2004 Business Wire
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2004, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Geographic Code:1CANA
Date:Jan 7, 2004
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