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Extensive test shows cholera vaccine works.


A reliable, long-lasting vaccine against cholera cholera (kŏl`ərə) or Asiatic cholera, acute infectious disease caused by strains of the bacterium Vibrio cholerae that have been infected by bacteriophages.  has eluded medical science. The best vaccine available during the 20th century was scrapped in the 1970s because it offered only weak protection. In the 1980s, Swedish researchers developed an oral vaccine, and trials done since then have indicated that it offers better protection than the abandoned vaccine did.

In its first massive test, the oral vaccine has proved effective in preventing the life-threatening diarrhea that cholera causes, researchers working in Mozambique report. These new data establish the vaccine's value for public health campaigns against cholera, suggests Jacqueline L. Deen of the International Vaccine Institute in Seoul, South Korea.

Mozambique accounts for 18 percent of all cholera cases worldwide, Deen notes. Many epidemics strike the country's marshy marsh·y  
adj. marsh·i·er, marsh·i·est
1. Of, resembling, or characterized by a marsh or marshes; boggy.

2. Growing in marshes.
 port city of Beira, which has poor water-supply and municipal-waste-disposal systems. Cholera spreads via tainted taint  
v. taint·ed, taint·ing, taints

v.tr.
1. To affect with or as if with a disease.

2. To affect with decay or putrefaction; spoil. See Synonyms at contaminate.

3.
 drinking water drinking water

supply of water available to animals for drinking supplied via nipples, in troughs, dams, ponds and larger natural water sources; an insufficient supply leads to dehydration; it can be the source of infection, e.g. leptospirosis, salmonellosis, or of poisoning, e.g.
.

At the start of a cholera outbreak during the rainy season spanning late 2003 and early 2004, clinics in Beira dispensed dis·pense  
v. dis·pensed, dis·pens·ing, dis·pens·es

v.tr.
1. To deal out in parts or portions; distribute. See Synonyms at distribute.

2. To prepare and give out (medicines).

3.
 two doses of the oral cholera vaccine, a month apart, to each of nearly 50,000 people. In a follow-up study, Deen and her colleagues determined that the vaccine was up to 81 percent effective in preventing cholera. In children under age 5, the vaccine was particularly protective. That's a heartening heart·en  
tr.v. heart·ened, heart·en·ing, heart·ens
To give strength, courage, or hope to; encourage. See Synonyms at encourage.

Adj. 1.
 result, since it's primarily young children that cholera kills, Deen says.--N.S.
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Title Annotation:Cholera
Publication:Science News
Article Type:Brief Article
Geographic Code:6MOZA
Date:Dec 4, 2004
Words:225
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