Evidence is accumulating that nonoxynol-9 is ineffective as a vaginal microbicide.Evidence is accumulating that nonoxynol-9 is ineffective as a vaginal microbicide. Investigators in Cameroon randomly assigned 1,251 women at high risk for sexually transmitted disease sexually transmitted disease (STD) or venereal disease, term for infections acquired mainly through sexual contact. Five diseases were traditionally known as venereal diseases: gonorrhea, syphilis, and the less common granuloma inguinale, to use either condoms alone or condoms plus a nonoxynol-9 gel. By the end of six months of follow-up, they found no differences between the groups in rates of new urogenital urogenital /uro·gen·i·tal/ (-jen´i-tal) genitourinary. u·ro·gen·i·tal or u·ri·no·gen·i·tal adj. Genitourinary. infections, gonorrhea infections or chlamydia infections. The findings are consistent with results of an earlier study in Cameroon. [Roddy RE et al., Effect of nonoxynol-9 on urogenital gonorrhea and chlamydial infection: a randomized controlled trial A randomized controlled trial (RCT) is a scientific procedure most commonly used in testing medicines or medical procedures. RCTs are considered the most reliable form of scientific evidence because it eliminates all forms of spurious causality. , JAMA JAMA abbr. Journal of the American Medical Association , 2002, 287(9):1117-1122.] |
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