Errata.Siemiatycki et al. have detected some errors in their review of occupational carcinogens Carcinogens Substances in the environment that cause cancer, presumably by inducing mutations, with prolonged exposure. Mentioned in: Colon Cancer, Rectal Cancer published in the November 2004 issue of EHP EHP abbr. 1. effective horsepower 2. electric horsepower [Environ Health Perspect 112:1447-1459 (2004)]. Specifically, they inadvertently included in their list of Group 2B (possible) carcinogens some substances that had been downgraded to Group 3 (not classifiable) in a subsequent MRC See Maximum return criterion. (International Agency for Research on Cancer The International Agency for Research on Cancer (IARC, or CIRC in its French acronym) is an intergovernmental agency forming part of the World Health Organisation of the United Nations. Its main offices are in Lyon, France. ) Monograph. Their corrections are as follows: * On page 1449, 3rd column, "113 possible human occupational carcinogens (IARC Group 2B; Table 5)" should be replaced by "110 possible human occupational carcinogens (IARC Group 2B; Table 5)." * On page 1454, Table 5 (under "Respirable respirable /res·pir·a·ble/ (re-spir´ah-b'l) 1. suitable for respiration. 2. small enough to be inhaled. res·pi·ra·ble adj. 1. Fit for breathing, as air. dusts and fibers"), glass wool glass wool n. Fine-spun fibers of glass used especially for insulation and in air filters. Noun 1. glass wool - glass fibers spun and massed into bundles resembling wool , rock wool rock wool n. See mineral wool. Noun 1. rock wool - a light fibrous material used as an insulator mineral wool , and slag wool mineral wool. See under Mineral. Same as See also: Slag Wool fireproofing fireproofing, method of making normally combustible materials as nearly noncombustible as possible. Fireproofing generally applies to textiles and construction materials that are treated with a solution or coating of some substance that will tend to retard their should not have appeared in the listing of Group 2B human carcinogens because they were downgraded to Group 3 in the latest monograph to address these substances (IARC 2002a); special purpose glass fibers such as E-glass and "475" glass fibers are not used in the "Reinforced plastic industry" but rather in "High-efficiency air filtration media and battery separator media" (IARC 2002a). A corrected version of this section of Table 5 is presented below. * On page 1459, Table 8, as a result of the previous corrections, the last section of Table 8 (Current rating 2B) should be modified as follows: the total number of substances with this rating should read 110 instead of 113; the number of substances unrated by IARC in 1987 should read 36 instead of 39; and the number of substances unrated by the World Health Organization (WHO) in 1964 should read 104 instead of 107. A corrected version of Table 8 is presented below. Siemiatycki et al.'s review of the IARC Monographs was intended to cover volumes 1-83. With these corrections, the tables and text are complete. REFERENCES IARC. 1987. Overall Evaluations of Carcinogenicity carcinogenicity /car·ci·no·ge·nic·i·ty/ (kahr?si-no-je-nis´i-te) the ability or tendency to produce cancer. carcinogenicity the ability or tendency to produce cancer. : An Updating of IARC Monographs Volumes 1 to 42. IARC Monogr Eval Carcinog Risk Chem Hum hum (hum) a low, steady, prolonged sound. venous hum a continuous blowing, singing, or humming murmur heard on auscultation over the right jugular vein in the sitting or erect position; it is (suppl 7). IARC. 1997b. Silica silica or silicon dioxide, chemical compound, SiO2. It is insoluble in water, slightly soluble in alkalies, and soluble in dilute hydrofluoric acid. Pure silica is colorless to white. , Some Silicates, Coal Dust and Para-aramid Fibrils. IARC Monogr Eval Carcinog Risks Hum 68. IARC. 2002a. Man-Made Vitreous vitreous /vit·re·ous/ (vit´re-us) 1. glasslike or hyaline. 2. vitreous body. primary persistent hyperplastic vitreous Fibres. IARC Monogr Eval Carcinog Risks Hum 81. WHO. 1964. Prevention of Cancer. Report of a WHO Committee. Technical Report Series 276. 6eneva:World Health Organization.
Table 5. Substances and mixtures that have been evaluated by IARC as
possible (Group 2B) human carcinogens and that are occupational
exposures [corrected section only].
Substance Occupation or industry in which
or mixture the substance is found (a)
Respirable dusts and fibers
Palygorskite (long fibers > 5 Miners and millers; production
[micro]m) of waste absorbents,
fertilizers, and pesticides
Refractory ceramic fibers Production; furnace insulators;
ship builders, heat-resistant
fabric manufacture
Special-purpose glass fibers such as High-efficiency air filtration
E-glass and "475" glass fibers media, battery separator
media
Substanceor IARC Monograph Human
mixture volume (year) (b) evidence
(c)
Respirable dusts and fibers
Palygorskite (long fibers > 5 Vol. 68 (1997b) Inadequate
[micro]m)
Refractory ceramic fibers Vol. 81 (2002a) Inadequate
Special-purpose glass fibers such as Vol. 81 (2002a) Not
E-glass and "475" glass fibers available
Substance Animal
or mixture evidence (c)
Respirable dusts and fibers
Palygorskite (long fibers > 5 Sufficient
[micro]m)
Refractory ceramic fibers Sufficient
Special-purpose glass fibers such as Sufficient
E-glass and "475" glass fibers
Table 8. Evolution in knowledge regarding current
(2003) IARC occupational carcinogens (corrected
version).
Earlier evaluation
Current rating Past rating IARC 1987 WHO 1964
1 1 19 13
(n = 28) 2A 4 ] 4
2B 1 ]
3 0 NA
Unrated 4 11
Total 28 28
2A 1 0 0
(n = 27) 2A 16 ] 0
2B 6 ]
3 2 NA
Unrated 3 27
Total 27 27
2B 1 0 1
(n = 110) 2A 2 ] 5
2B 63 ]
3 9 NA
Unrated 36 104
Total 110 110
NA, not applicable.
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