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Elixir Pharmaceuticals to Present at BIO CEO and Investor Conference.


CAMBRIDGE, Mass. -- Elixir elixir /elix·ir/ (e-lik´ser) a clear, sweetened, alcohol-containing, usually hydroalcoholic liquid containing flavoring substances and sometimes active medicinal ingredients.

e·lix·ir
n.
 Pharmaceuticals announced today that William Heiden, President and Chief Executive Officer, is scheduled to participate in a panel discussion and to present a corporate update at the BIO CEO (1) (Chief Executive Officer) The highest individual in command of an organization. Typically the president of the company, the CEO reports to the Chairman of the Board.  and Investor Conference at The Waldorf=Astoria Hotel in New York, NY. The company presentation will take place in the hotel's Park Avenue Suite on Wednesday, February 14 at 11:15am. Mr. Heiden will also participate in the conference workshop entitled, "Baby Boomers - Where Are the Growth Market Opportunities?," which is scheduled for Wednesday, February 14 at 9:00 am in the Waldorf's Jade Room.

About Elixir Pharmaceuticals

Elixir is a Cambridge, MA-based biopharmaceutical company focused on developing and commercializing drugs to treat and prevent metabolic disease, and prevent age-related diseases, ultimately extending the quality and length of human life.

Elixir is advancing a novel proprietary potent, orally available ghrelin antagonist through lead optimization and is preparing to nominate a clinical candidate. Compounds are currently being evaluated in in-vivo models of Type 2 diabetes type 2 diabetes
n.
See diabetes mellitus.
 and obesity, both of which represent exciting drug development targets in metabolic disease and multi-billion dollar product opportunities.

In addition to its ghrelin antagonist program, the Company has leveraged its knowledge of ghrelin biology and pharmacology by licensing a small molecule ghrelin agonist (designated EX-1314) from Bristol-Myers Squibb Company in April 2005. EX-1314 binds selectively to the ghrelin receptor and mimics the body's naturally occurring ghrelin. In doing so this novel, orally available agent is capable of stimulating appetite, gastric motility motility /mo·til·i·ty/ (mo-til´ite) the ability to move spontaneously.mo´tile
Motility
Motility is spontaneous movement.
 and the release of growth hormone. Elixir is currently in IND-enabling studies with EX-1314 targeting a variety of therapeutic indications.

Further, in March 2006, Elixir in-licensed North and South American rights to Glufast[R] (mitiglinide calcium hydrate hydrate (hī`drāt), chemical compound that contains water. A common hydrate is the familiar blue vitriol, a crystalline form of cupric sulfate. Chemically, it is cupric sulfate pentahydrate, CuSO4·5H2O. ), an insulin secretagogue secretagogue /se·cret·a·gogue/ (se-kret´ah-gog) stimulating secretion, or an agent that so acts.

se·cre·ta·gogue
n.
A hormone or another agent that causes or stimulates secretion.
, which lowers post-meal glucose levels by improving the body's own ability to produce insulin. Already marketed in Japan, Glufast has undergone extensive clinical development demonstrating the product's ability to safely and effectively treat Type 2 diabetes.

Elixir has also developed expertise and a broad IP portfolio of more than twenty patents and patent applications related to the Sirtuin class of proteins, including small molecular weight SIRT1 activators and inhibitors. The Company's own R&D efforts and those of its numerous research partners utilizing modulators of SIRT1 (a human sirtuin) have significantly extended the SIRT knowledge base in recent years. Elixir is also actively pursuing drug discovery efforts focused on other key targets, such as AMP-activated kinase (AMPK AMPK AMP-Activated Protein Kinase
AMPK 5-Prime-Amp-Activated Protein Kinase
) and the INDY See Indigo.  gene, both of which have been implicated im·pli·cate  
tr.v. im·pli·cat·ed, im·pli·cat·ing, im·pli·cates
1. To involve or connect intimately or incriminatingly: evidence that implicates others in the plot.

2.
 in the regulation of aging and metabolism in a variety of organisms.

More information about Elixir is available at http://www.elixirpharm.com/
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Copyright 2007, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Publication:Business Wire
Date:Feb 8, 2007
Words:437
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