Elevated IL-8 linked to poor outcome after lung transplantation.High levels of interleukin-8 (IL-8) in donor lungs are associated with severe graft dysfunction and early morality, according to researchers at the University of Newcastle University of Newcastle can refer to:
In a study of 26 lung transplant lung transplant Surgery Transplant of a lung allograft into a Pt with failing lungs; 90 US centers perform LT; 35 centers perform ≥ 10/yr Mean wait time 18 months Indications COPD–eg, emphysema due to α1 recipients, increased IL-8 in the donor bronchoalveolar lavage Bronchoalveolar lavage A way of obtaining a sample of fluid from the airways by inserting a flexible tube through the windpipe. Used to diagnose the type of lung disease. fluid was associated with both severe early graft dysfunction and early death. The authors suggested that reducing preexisting pre·ex·ist or pre-ex·ist v. pre·ex·ist·ed, pre·ex·ist·ing, pre·ex·ists v.tr. To exist before (something); precede: Dinosaurs preexisted humans. v.intr. inflammation in the donor lung may improve early graft function and survival after lung transplantation. They further speculated that their findings may not be unique to the lung and could be relevant to early function of other solid organ transplants. (American Journal of Respiratory and Critical Care Medicine 2001;163:259-265.) |
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