Eisai Announces Results of Overseas Clinical Trials of Donepezil in Treating Vascular Dementia.Tokyo, Japan, Mar 17, 2006 - (JCN JCN Japan Corporate News JCN Journal of Cognitive Neuroscience JCN Journal of Cardiovascular Nursing JCN Journal of Christian Nursing JCN Job Control Number JCN Journal of Child Neurology JCN joint communications network (US DoD) ) - Eisai announced the results of its latest clinical trials of donepezil in patients with vascular dementia vascular dementia n. A steplike deterioration in intellectual functions that result from multiple infarctions of the cerebral hemispheres. Also called multi-infarct dementia. (VaD) on March 16. Randomized ran·dom·ize tr.v. ran·dom·ized, ran·dom·iz·ing, ran·dom·iz·es To make random in arrangement, especially in order to control the variables in an experiment. , double-blinded tests were conducted in nine countries with patients with VaD and with no prior diagnosis of Alzheimer's disease Alzheimer's disease (ăls`hī'mərz, ôls–), degenerative disease of nerve cells in the cerebral cortex that leads to atrophy of the brain and senile dementia. . Compared with a placebo group, the subjects receiving donepezil showed significant improvement in cognitive functions but not in global functions. No statistically significant difference in the occurrence of adverse effects was observed. However, the mortality rate was higher in the donepezil group than the placebo one. In the US, Japan and the EU, donepezil, under the trade name Aricept, is currently indicated for the treatment of mild to moderate Alzheimer's disease but not for VaD. In the meantime Adv. 1. in the meantime - during the intervening time; "meanwhile I will not think about the problem"; "meantime he was attentive to his other interests"; "in the meantime the police were notified" meantime, meanwhile , it is available for the treatment of VaD in India, New Zealand, the Philippines, Romania, South Korea and Thailand. Copyright [c] 2006 Japan Corporate News Network. All rights reserved. |
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