ERGOLOID MESYLA.TES (HYDERGINE).MODE OF ACTION Mechanism is unclear, but may improve cerebral blood flow. EFFECTS ON ALZHEIMER'S DISEASE May have modest benefits in a variety of age-related mental impairment. CONTRAINDICATIONS Known hypersensitivity to ergoloid mesylates. Acute or chronic psychosis. Pregnancy Category D. ADVERSE EFFECTS Gastrointestinal adverse effects, such as nausea. DRUG-DRUG INTERACTIONS Delavirdine delavirdine /del·a·vir·dine/ (del?ah-vir´den) an antiretroviral, inhibiting reverse transcriptase; used as the mesylate salt in the treatment of HIV infection. del·a·vir·dine n. (Rescriptor), indinavir (Crixivan), nelfinavir nelfinavir /nel·fin·a·vir/ (nel-fin´ah-vir) an HIV protease inhibitor that causes formation of immature, noninfectious viral particles; used as the mesylate salt in the treatment of HIV infection. (Viracept), saquinavir (Fortovase), and efavirenz (Sustiva) may increase ergot ergot (ûr`gət), disease of rye and other cereals caused by the fungus Claviceps purpurea. The cottony, matlike body, or mycelium, of the fungus develops in the ovaries of the host plant; it eventually turns into a hard pink or purple levels resulting in ergotism ergotism /er·got·ism/ (er´go-tizm) chronic poisoning produced by ingestion of ergot, marked by cerebrospinal symptoms, spasms, cramps, or by a kind of dry gangrene. er·got·ism n. (nausea, vomiting, and vasospastic ischemia). Ergoloid mesylates should NEVER be given with naratriptan (Amerge), rizatriptan (Maxalt), or zolmitriptan zolmitriptan /zol·mi·trip·tan/ (zol?mi-trip´tan) a selective serotonin receptor agonist used to relieve acute migraine. zol·mi·trip·tan n. (Zomig) due to the potential for vasospastic reactions. RECOMMENDED DOSE Initial dose is 1 mg three times a day. May titrate ti·trate v. To determine the concentration of a solution by titration or perform the operation of titration. ti up to 12 mg/day, although 6 mg/day is usually an effective dose. May take up to 6 months before efficacy can be determined. DOSAGE FORMS AVAILABLE Oral tablets: 0.5 mg and 1 mg. Sublingual tablets: 0.5 mg and 1 mg. Liquid capsule: 1 mg. Liquid: 1 mg/ml. MANUFACTURER Rugby, Sandoz, and various generic companies. OTHER POINTS OF INTEREST Sublingual tablets should not be crushed or chewed. This therapy is rarely used. References (1.) Hutchison TA, Shahan DR, Anderson ML (Eds): DRUGDEX System. MICROMEDEX, Inc., Englewood, Colorado (Edition expires 12/2000). (2.) Hebel SK. Katstrup EK (Eds): Drug Facts and Comparisons. St. Louis, MO (2001). |
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