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EPIX Pharmaceuticals Announces Formation of Technology Advisory Board.

Board Comprised of Leaders in the Computational Technologies Field

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:EPIX), a biopharmaceutical company focused on discovering and developing novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform, today announced the formation of a Technology Advisory Board (TAB) that includes several leaders in the field of computational technologies. The EPIX TAB has been established to advise the company on key aspects of its computational technologies including EPIX's proprietary in silico modeling for drug discovery. The charter members of the TAB, convening its inaugural session this week, include Charles L. Brooks, III, Ph.D., Johan Aqvist, Ph.D., and Gabriele Cruciani, Ph.D.

"We are pleased to announce the formation of the EPIX Technology Advisory Board and welcome the additional experience and knowledge of these accomplished thought-leaders, which should be additive to our current and future in silico discovery and development efforts," said Hanoch Senderowitz, executive director of Computational Development. "We believe the TAB is a vital strategic asset for our continued growth, and we look forward to collaborating with the members of our TAB as we continue to pursue new discovery targets, develop our lead therapeutic product candidates and expand our proprietary technology footprint."

About the EPIX TAB

Charles L. Brooks, III, Ph.D.

Professor Brooks is the Warner-Lambert/Parke-Davis professor of chemistry and a professor of biophysics biophysics, application of various methods and principles of physical science to the study of biological problems. In physiological biophysics physical mechanisms have been used to explain such biological processes as the transmission of nerve impulses, the muscle  in the Department of Chemistry at the University of Michigan (body, education) University of Michigan - A large cosmopolitan university in the Midwest USA. Over 50000 students are enrolled at the University of Michigan's three campuses. The students come from 50 states and over 100 foreign countries. .

Professor Brooks' research interests focus on the application of statistical mechanics statistical mechanics, quantitative study of systems consisting of a large number of interacting elements, such as the atoms or molecules of a solid, liquid, or gas, or the individual quanta of light (see photon) making up electromagnetic radiation. , quantum chemistry and computational methods to chemically- and physically-oriented problems in biology. His current research interests include: free energy based methods for screening and optimization lambda-dynamics; ligand docking, protein stability and continuum based free energy approximations; the development of new polarizable po·lar·ize  
v. po·lar·ized, po·lar·iz·ing, po·lar·iz·es
1. To induce polarization in; impart polarity to.

2. To cause to concentrate about two conflicting or contrasting positions.
 force fields for proteins, lipids and small molecules; protein folding; and, protein structure prediction Protein structure prediction is one of the most important goals pursued by bioinformatics and theoretical chemistry. Its aim is the prediction of the three-dimensional structure of proteins from their amino acid sequences, sometimes including additional relevant information such as , ab initio [Latin, From the beginning; from the first act; from the inception.] An agreement is said to be "void ab initio" if it has at no time had any legal validity.  folding, homology modeling. Professor Brooks is the author/co-author of more than 240 journal articles and book chapters.

Johan Aqvist, Ph.D.

Professor Aqvist is a professor of theoretical chemistry in the Department of Cell and Molecular Biology Cell and Molecular Biology may refer to:
  • Cell biology
  • Molecular biology
 at Uppsala University, Sweden. Research in his group is focused on protein structure and function with a particular emphasis on enzymatic catalysts and binding energies between proteins and their ligands.

Professor Aqvist is the developer of the Linear Interaction Energy (LIE) method which he has successfully applied to the prediction of binding free energies in a variety of systems. Dr. Aqvist also is conducting work on the hERG channel; a large scale hERG binding prediction project is currently ongoing in his lab. Professor Aqvist is the author/co-author of more than 130 journal articles and book chapters.

Gabriele Cruciani, Ph.D.

Professor Cruciani is a professor of organic chemistry and cheminformatics in the Laboratory for Chemometrics and Cheminformatics at the University of Perugia The official seal of the university portraits Saint Herculan, one of the saint patrons, and the rampant crowned griffin, which is the city symbol: they represent the ecclesiastical and civil powers, respectively, which gave rise to the university in the Middle Ages. , Italy. In addition, he serves as the scientific director of Molecular Discovery Ltd., a scientific software company focused on the development of computational tools based on the GRID force field with an emphasis on ADMET ADMET Acyclic Diene Metathesis
ADMET Absorption, Distribution, Metabolism, Excretion, and Toxicity (drug properties) 

Professor Cruciani's expertise includes ADMET predictions with a particular emphasis on hERG and CYPs. Professor Cruciani is the author/co-author of more than 100 journal articles and book chapters.

About EPIX

EPIX Pharmaceuticals is a biopharmaceutical company focused on discovering and developing novel therapeutics through the use of its proprietary and highly efficient in silico drug discovery platform. The company has a pipeline of internally-discovered drug candidates currently in clinical development to treat diseases of the central nervous system and lung conditions. EPIX also has collaborations with leading organizations, including GlaxoSmithKline, Amgen, Cystic Fibrosis Foundation The Cystic Fibrosis Foundation (CFF) is a non-profit organization in the United States established to provide the means to cure and control cystic fibrosis. The Foundation provides information about cystic fibrosis (CF) and finances CF research that aims to improve the  Therapeutics and Bayer Schering Pharma. For more information, please visit the company's website at
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Publication:Business Wire
Date:Aug 14, 2008
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