EP MedSystems' Ultrasound Product Used in Heart Failure Treatment.

WEST BERLIN, N.J. -- EP MedSystems, Inc. (NASDAQ: EPMD), a market leader in electrophysiology products used in cardiac rhythm management, today announced that its ViewFlex(TM) ultrasound imaging catheter was used in a unique procedure to treat a patient in dysynchrony with heart failure. The procedure was performed by Sanjeev Saksena, MD, the Company's Senior Medical Advisor. Dr Saksena is practicing cardiac electrophysiology and Clinical Professor of Medicine at the Robert Wood Johnson School of Medicine in New Brunswick, New Jersey.

The procedure was successfully performed to resynchronize the left ventricle in a patient who previously had an implanted cardiac resynchronization pacemaker device, which had failed to improve heart function. Cardiac resynchronization therapy (CRT) is an innovative new therapy that can relieve heart failure symptoms by improving the coordination of the heart contractions. EP MedSystems' ViewMate(R) system provided visualization used in both optimizing the positioning of the pacemaker electrode and the programming of the device, allowing resynchronization as well as increased cardiac output. The patient's ejection fraction, the percentage of blood that is pumped out of a filled ventricle with each heartbeat, improved from 21% to 39%.

Dr Saksena stated, "The real time measurements from EP MedSystems' ViewFlex(TM) catheter allowed me to optimize the intended therapy of the implanted resynchronization device, thereby improving the patient's heart function. We see failed resynchronization therapy in 30-40% of patients implanted with these devices. I believe that utilization of this ultrasound technique during original implant procedures, could improve success rates significantly, benefiting the patients."

Studies have shown that cardiac resynchronization therapy can improve quality of life for heart failure patients by reducing symptoms like fatigue and shortness of breath. Heart failure is a condition that progressively weakens the heart and therefore loses its ability to pump an adequate supply of blood to the body. Approximately 5 million Americans suffer from heart failure, with approximately 550,000 new cases diagnosed each year. The economic burden of heart failure is estimated at $40 billion per year.

EP MedSystems' ViewMate(R) ultrasound system is a fully computerized instrument for the capture of intracardiac ultrasound images. It provides digital image acquisition and display of images from the ViewFlex(TM) intracardiac catheter inserted into the heart through intravascular access.

EP MedSystems will be sponsoring a symposium at the upcoming HRS meeting in Boston, MA. The symposium is entitled New Clinical Techniques and Imaging Technology in Interventional Electrophysiology. This symposium will focus on two areas of clinical importance; Atrial Fibrillation, as well as, New Directions in Interventional Electrophysiology. After the presentations, the Symposium will conclude with a panel discussion. The chairman for the symposium will be Dr. Bradley Knight, University of Chicago, Dr. Fred Kusumoto, Mayo Clinic, Dr. James Maloney, Carondelet Heart Institute and Dr. Steven A. Kutalek, Hahnemann University Hospital. The symposium will be held on Thursday May 18th, 2006 from 7:00 to 9:00PM at the Essex North/Center Ballroom in the Westin Copley Hotel.

About EP MedSystems:

EP MedSystems develops and markets cardiac electrophysiology ("EP") products used to diagnose and treat certain cardiac rhythm disorders. The Company's EP product line includes the EP-WorkMate(R) Electrophysiology Workstation with RPM(TM) Real-time Position Management(TM) navigation technology, the EP-4(TM) Computerized Cardiac Stimulator, fixed and deflectable diagnostic electrophysiology catheters and related disposable supplies, the ALERT(R) System and ALERT family of internal cardioversion catheters, and the ViewMate(R) intracardiac ultrasound catheter imaging system. For more information, visit our Website at www.epmedsystems.com.

Forward Looking Statements:

This Release may contain certain statements of a forward-looking nature relating to future events or the future financial performance of the Company. Forward-looking statements include information concerning our possible or assumed future results of operations and statements preceded by, followed by or including the words "believes", "expects", "anticipates", "intends", "plans", "estimates", or similar expressions. Such forward-looking statements are based on our management's beliefs and assumptions and on information currently available to our management. Such forward-looking statements are only predictions and are subject to risks and uncertainties that could cause actual results or events to differ materially and adversely from the events discussed in the forward-looking statements. Factors that could cause or contribute to such differences include, but are not limited to, EP MedSystems' history of losses, uncertainty of market acceptance of our products and level of sales, uncertainty of future profitability and future liquidity needs; possible costs, fines or penalties that may be incurred in connection with government inquiries and investigations and risks regarding regulatory approvals and demand for new and existing products, as stated in the Company's Annual Report filed on Form 10-K and quarterly reports filed on Form 10-Q.

EP MedSystems cautions investors and others to review the cautionary statements set forth in this press release and in EP MedSystems' reports filed with the Securities and Exchange Commission and cautions that other factors may prove to be important in affecting the EP MedSystems' business and results of operations. Readers are cautioned not to place undue reliance on this press release and other forward-looking statements, which speak only as of the date of this press release. EP MedSystems undertakes no obligation to publicly release the results of any revisions to these forward-looking statements that may be made to reflect events or circumstances after the date of this press release or to reflect the occurrence of unanticipated events.