EGCG, COX-2 inhibitor fight prostate cancer.The combination of a COX-2 (cyclooxygenase-2) inhibitor drug and the green tea polyphenol polyphenol Any of various alcohols containing two or more benzene rings that each have at least one hydroxyl group (OH) attached. Many polyphenols occur naturally in plants and some kinds, such as the flavonoids and tannins, are believed to be beneficial EGCG EGCG Epigallocatechin Gallate (antioxidant in green tea) (epigallocatechin gallate) works synergistically syn·er·gis·tic adj. 1. Of or relating to synergy: a synergistic effect. 2. Producing or capable of producing synergy: synergistic drugs. 3. to thwart prostate cancer in cell cultures and live animals, according to a recent report. * [ILLUSTRATION OMITTED] While scientists have known for years that anti-inflammatory COX-2 inhibitors (such as celecoxib, or Celebrex[R]) may help prevent cancer, concerns about the toxicity of these drugs, particularly Vioxx[R], has spurred a search for complementary agents that can be combined with low doses of the drugs to help prevent cancer. When three lines of human prostate cancer cells were treated with EGCG, a COX-2 inhibitor used in experimental studies called NS398, or a combination of the two in the laboratory, the combination resulted in greater inhibition of cancer cell growth and increased apoptosis (programmed cell death pro·grammed cell death n. See apoptosis. programmed cell death proposed system of cell death, often including poly(ADP)-ribosylation, ensures that a cell will not survive if it is so badly damaged that its recovery would harm the ) than either agent alone. In mice implanted with human prostate cancer cells, combination treatment with EGCG and celecoxib inhibited tumor growth and reduced levels of PSA (Professional Services Automation) An information system designed to organize, track and manage all opportunities, work, resources, costs, revenues and invoices to improve the productivity and efficiency of the workforce. (prostate-specific antigen, a marker of prostate disease). Reference * Adhami VM, Malik A, Zaman N, et al. Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin Cancer Res. 2007 Mar 1;13(5):1611-9. |
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