Drug-resistant HIV in the UK.The prevalence of drug-resistant HIV HIV (Human Immunodeficiency Virus), either of two closely related retroviruses that invade T-helper lymphocytes and are responsible for AIDS. There are two types of HIV: HIV-1 and HIV-2. HIV-1 is responsible for the vast majority of AIDS in the United States. in the United Kingdom is high and appears to be rising, according to according to prep. 1. As stated or indicated by; on the authority of: according to historians. 2. In keeping with: according to instructions. 3. an analysis of national data for 1996-2003. (1) During the study period, 14% of HIV-positive individuals who were tested for drug resistance before beginning treatment had a strain of the virus that would not respond to at least one anti-retroviral drug used to treat the infection; the prevalence rose from 11% in 1996-1997 to 19% in 2002-2003. Drug-resistant virus was more common in recently infected individuals than in those whose duration of infection was unknown (22% vs. 14%); other clinical factors, as well demographic characteristics, were at best only marginally associated with the prevalence of resistance. The researchers note that "by limiting the therapeutic options for a significant number of patients, the secondary epidemic of drug resistant HIV represents a major clinical and public health problem." (1.) UK Group on Transmitted HIV Drug Resistance HIV drug resistance Antiretroviral drug resistance AIDS The resistance of a strain of HIV to an agent–eg, a reverse transcriptase inhibitor, which occurs in 5%-20% of those newly infected with HIV , Time trends in primary resistance to HIV drugs in the United Kingdom: multicentre observational study In statistics, the goal of an observational study is to draw inferences about the possible effect of a treatment on subjects, where the assignment of subjects into a treated group versus a control group is outside the control of the investigator. , BMJ BMJ n abbr (= British Medical Journal) → vom BMA herausgegebene Zeitschrift , 2005, 331 (7529):1368-1373. |
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