Printer Friendly

Drug protects mouse eggs from radiation. (Biomedicine).

A drug that might preserve the fertility of women undergoing radiation treatment for cancer has met an important challenge. Female mice treated with the drug and then irradiated give birth to healthy offspring, according to a new study.

When women undergo radiation therapy, the treatment usually causes most of their egg cells to die, apparently because the radiation damages the cells' DNA. Over the past few years, researchers have explored the potential of sphingosine 1-phosphate (S1P), a type of lipid, to protect egg cells. S1P counters an enzyme that destroys radiation-damaged egg cells, and previous research has shown that injections of S1P into mice receiving radiation reduced egg deaths (SN: 10/7/00, p. 228).

However, that result left open the question of whether the surviving egg cells were normal. At the American Society for Cell Biology meeting last month in San Francisco, Richard N. Kolesnick of Memorial Sloan-Kettering Cancer Center in New York reported that irradiated female mice pretreated with S1P are fertile and that their offspring and a subsequent generation don't have increased rates of genetic or physical defects. Kolesnick and his colleagues detailed some of their findings in the September, 2002 Nature Medicine.--J.T.
COPYRIGHT 2003 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2003, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Science News
Article Type:Brief Article
Geographic Code:1USA
Date:Jan 18, 2003
Previous Article:Cheap hypertension drug works best. (Biomedicine).
Next Article:Why didn't the beetle cross the road? (Environment).

Related Articles
Dancer gets first ovarian-tissue transplant.
Drug spares eggs from early death.
Ionizing Radiation Now Approved for Shell Eggs.
Saving fertility for cancer survivors?
Radiation harms blood vessels before gut.
Kill the cancer, save the eggs. (Reproductive Health).
Tiny device brings out the best in sperm. (Technology).
Stem cells may make new eggs in women.
Cells in bloodstream don't refill ovaries.
People want to know.

Terms of use | Copyright © 2016 Farlex, Inc. | Feedback | For webmasters