Drug for preemies linked to problems.Treating premature infants with a common steroid can prevent chronic lung disease lung disease Pulmonary disease Pulmonology Any condition causing or indicating impaired lung function Types of LD Obstructive lung disease–↓ in air flow caused by a narrowing or blockage of airways–eg, asthma, emphysema, chronic bronchitis; , but possibly at a cost, a new study finds. Scientists in Taiwan randomly assigned 262 premature infants, all on respirators, to receive periodic infusions of either dexamethasone dexamethasone /dex·a·meth·a·sone/ (dek?sah-meth´ah-son) a synthetic glucocorticoid used primarily as an antiinflammatory in various conditions, including collagen diseases and allergic states; it is the basis of a screening test in the or saline solutions for 4 weeks. Many premature infants need respirators, but the force of the machines can damage preemie lungs. Babies treated with dexamethasone had half as much chronic lung disease after the first month of life as did infants getting the saline. Roughly two-fifths of the children in each group died before reaching school age. Follow-up of 146 of the survivors at an average age of 8 years showed that those who had received the steroid tended to be shorter and had smaller head circumferences than did children who had received the inert treatment. Dexamethasone-tended children also had poorer motor coordination Gross motor coordination addresses the gross motor skills: walking, running, climbing, jumping, crawling, lifting one's head, sitting up, etc. Fine motor coordination , lower IQs, and more disabilities, the researchers report in the March 25 New England Journal of Medicine The New England Journal of Medicine (New Engl J Med or NEJM) is an English-language peer-reviewed medical journal published by the Massachusetts Medical Society. It is one of the most popular and widely-read peer-reviewed general medical journals in the world. . Study coauthor Tsu F. Yeh of China Medical University in Taichung, Taiwan, says that doctors treating premature infants with dexamethasone should consider substituting hydrocortisone hydrocortisone (hī'drəkôr`tĭzōn'), another name for the steroid hormone cortisol, more especially used to refer to preparations of this hormone used medicinally. , a less potent steroid.--N.S. |
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