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Diuretics in kidney cancer studied.

Diuretics in Kidney Cancer Studied

WASHINGTON, D.C.: The National Cancer Institute (NCI) is gearing up to begin a 1,200-subject study to examine the role diuretics might play in the development of kidney cancer. The study, supported by a $900,000 grant from NCI, will begin in the fall, under the direction of Dr. Joseph McLaughlin. Results of the study are expected by 1992 at the earliest, he said.

Diuretics are used to treat hypertension and congestive heart failure and to relieve body swelling from a number of causes. They work by preventing the reabsorption of sodium and water by the kidney, which promotes urine formation.

The study, which will look at men and women ranging in age from 20 to 79 years, will be conducted in areas of the United States that have cancer registries and are inhabited by people of Scandinavian and German descent who are at high risk of kidney cancer. Minnesota and Seattle are being considered as sites.

The 600 kidney-cancer patients and 600 cancer-free controls who agree to participate in the study will be interviewed in person regarding a number of lifestyle variables that might be a risk for kidney cancer - such as tobacco smoking, use of analgesics and other medications, body weight, diet, and occupational history.

The interviews will also "pick up information on coffee use, beverage use, and overall liquid intake," which affects kidney function. Blood will be drawn and stored for genetic testing from subjects with a positive family history of kidney cancer or bilateral kidney disease, or a diagnostic of kidney cancer under the age of 45.
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Publication:Nutrition Health Review
Date:Jun 22, 1989
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