DiscoveRx Now Offers the Broadest Panel of Beta-Arrestin GPCR Assays.FREMONT, Calif. -- DiscoveRx Corporation today announced that it has expanded its cell-based PathHunter(TM) [eth]-Arrestin assays to include 45 validated cell products, each expressing a different Gi, Gs or Gq -coupled receptor. By offering cells, GPCR GPCR Guanine Nucleotide-Binding Protein-Coupled Receptor GPCR GTP-binding Protein-Coupled Receptor expression vectors expression vector n. A vector, such as a plasmid, yeast, or animal virus genome, used to introduce foreign genetic material into a host cell in order to replicate and amplify the foreign DNA sequences as a recombinant molecule. , and custom services for all GPCR classes--without a license fee--DiscoveRx now has the broadest, most accessible product portfolio for measuring direct activation of GPCR signaling. PathHunter[TM] [eth]-Arrestin Assays are the first chemiluminescent chem·i·lu·mi·nes·cence n. Emission of light as a result of a chemical reaction at environmental temperatures. chem GPCR assays that measure the activation of Gi, Gs and Gq coupled receptor signaling by direct arrestin recruitment--rather than through a secondary messenger. Moreover, unlike imaging assays, a fast and simple, single-addition protocol is used, which provides broad assay window and robust z'. Combined, these breakthroughs make [eth]-Arrestin Assays the ideal universal GPCR screening platform. DiscoveRx introduced the PathHunter Arrestin technology in the spring of 2006 and, in keeping with its strategic goal of product enhancement and expansion, now offers the widest variety of whole cell assays for measuring translocation translocation /trans·lo·ca·tion/ (trans?lo-ka´shun) the attachment of a fragment of one chromosome to a nonhomologous chromosome. Abbreviated t. , secretion, degradation, expression and protein:protein interactions. "DiscoveRx is a leader in GPCR screening technology and we are excited to provide a whole suite of products that address a variety of screening needs," said Pyare Khanna, Ph.D, Chief Executive Officer of DiscoveRx. "DiscoveRx is committed to fueling drug discovery research by developing simple solutions for complex screening needs of targets with important biological and therapeutic relevance." Founded in 2000, DiscoveRx is a privately held, venture-backed company headquartered in Fremont, California For the unincorporated community in Yolo County, California, see . Fremont (IPA: /ˈfriːmɒnt/) is a city in California that was incorporated on January 23, 1956, from the merger of five smaller communities: , with an additional office in Birmingham, England. The Company pioneered the use of [eth]-galactosidase enzyme fragment complementation Complementation (genetics) The complementary action of different genetic factors. The term usually implies two homologous chromosomes or chromosome sets, each defective because of mutation and unable by itself to promote the normal development or metabolism of in biochemical bi·o·chem·is·try n. 1. The study of the chemical substances and vital processes occurring in living organisms; biological chemistry; physiological chemistry. 2. and cell based assays for discovery research, and holds extensive intellectual property in this area. DiscoveRx is dedicated to the development and commercialization of innovative solutions to study GPCRs, Kinases and other major drug target classes, and many of their innovative products have been widely adopted in pharmaceutical and biotech bi·o·tech n. Informal Biotechnology. biotech Noun short for biotechnology Noun 1. drug screening laboratories worldwide. The Company is also the recipient of Frost and Sullivan's prestigious 2006 Award for Technology Innovation. This award was given in recognition for successful introduction of PathHunter(TM) cell based assay platform and company's overall work on intact and/or lysed cell based assays. For more information on DiscoveRx products, please visit www.discoverx.com |
|
||||||||||||
Printer friendly
Cite/link
Email
Feedback
Reader Opinion