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Dicerna Pharmaceuticals to Present at 2009 Biologics Drug Delivery & Beyond Conference.

WATERTOWN, Mass. -- Dicerna Pharmaceuticals, Inc., a second generation RNA interference RNA interference
A process in which the introduction of double-stranded RNA into a cell inhibits the expression of genes.
 (RNAi) company developing novel therapeutics therapeutics

Treatment and care to combat disease or alleviate pain or injury. Its tools include drugs, surgery, radiation therapy, mechanical devices, diet, and psychiatry.
 utilizing its proprietary Dicer dic·er  
A device used for dicing food.

Noun 1. dicer - a mechanical device used for dicing food
mechanical device - mechanism consisting of a device that works on mechanical principles
 Substrate Technology[TM] and dicer substrate RNAi molecules, today announced that Sujit K. Basu, Ph.D., senior director, formulation, will be presenting at Biologics Drug Delivery & Beyond, being held September 23-25, 2009 at the Sheraton Hotel in Boston.

Dr. Basu will present a case study entitled en·ti·tle  
tr.v. en·ti·tled, en·ti·tling, en·ti·tles
1. To give a name or title to.

2. To furnish with a right or claim to something:
 "Creating Novel Therapeutics with Superior Potency potency /po·ten·cy/ (po´ten-se)
1. the ability of the male to perform coitus.

2. the relationship between the therapeutic effect of a drug and the dose necessary to achieve that effect.

, Duration of Action and Unique Delivery Potential by Harnessing Second Generation Dicer Substrate RNAs (DsiRNAs)" at 9:15 a.m. EST EST electroshock therapy.

electroshock therapy
 on September 25, 2009. The presentation will demonstrate reduction of target gene expression in a highly selective and specific fashion using DsiRNA therapeutics. The presentation will also compare this second generation RNAi strategy to other RNAi approaches, and identify how the extra length and unique properties of DsiRNAs provide excellent opportunities for targeted therapeutics and integrated delivery.

About RNAi

First described in plants and then in worms, flies and higher organisms, RNA interference (RNAi) is a key cellular mechanism regulating gene expression in both normal and disease processes. Dicer is a critical enzyme involved in the gene-silencing cascade. Dicer processing of double-stranded RNA RNA: see nucleic acid.
 in full ribonucleic acid

One of the two main types of nucleic acid (the other being DNA), which functions in cellular protein synthesis in all living cells and replaces DNA as the carrier of genetic
 oligonucleotides of 25 or more base pairs and hand-off to the gene-silencing complex (RISC RISC
 in full Reduced Instruction Set Computing

Computer architecture that uses a limited number of instructions. RISC became popular in microprocessors in the 1980s.
) results in a five-to-10-fold more potent activity and longer duration of action.

About Dicerna

Dicerna Pharmaceuticals is a private, venture-backed RNAi-focused biopharmaceutical company developing novel therapeutic agents in multiple disease areas based on its proprietary Dicer Substrate Technology platform. Dicerna is developing second generation RNAi-based therapies, and related drug delivery systems, that use the engagement of the enzyme Dicer, which is an earlier step in the gene silencing process and a natural initiation point for the RNAi cascade. This distinct biological pathway demonstrates greater potency and a longer duration of action, differentiating it from other RNAi approaches, and resulting in the knockdown of expression of a targeted gene in a way that is highly selective and specific. In collaboration with Archemix Corp., Dicerna is developing DsiRNA-aptamer conjugates to leverage both the potent gene silencing of Dicerna's DsiRNA molecules and the targeted delivery capabilities of Archemix's aptamers. Dicerna believes that its Dicer Substrate Technology is based on intellectual property that is both broadly enabling and distinct from other IP in the field. Dicerna has exclusive, worldwide rights to the Dicer Substrate Technology and has the sole right to grant sublicenses to the full portfolio of Dicer Substrate intellectual property. Dicerna is based in Watertown, Massachusetts The Town of Watertown is a city[1] in Middlesex County, Massachusetts, United States. The population was 32,986 at the 2000 census. History
Watertown, first known as Saltonstall Plantation, was one of the earliest of the Massachusetts Bay settlements.
. For more information, please visit
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Publication:Business Wire
Article Type:Conference news
Date:Sep 21, 2009
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