Diagnostic Systems Laboratories Inc. is Granted an Exclusive License for Inhibin-A from Oxford Bio-Innovative.WEBSTER, Texas--(BW HealthWire)--Oct. 15, 1999-- Diagnostic Systems Laboratories Inc., a privately owned company, announced that it had received exclusive distribution rights from Oxford Bio-Innovation Ltd. for the sale and manufacture of Inhibin-A assay kits. Oxford Bio-Innovation Ltd. is a Joint Venture Company, owned by Serotec Ltd. (Oxford, UK) and Oxford Brookes University Oxford Brookes University is a public university in Oxford, England. Overview The University has roots in Oxford that go back to 1865 (when it was known as the Oxford School of Art). The present student body is 19,000. (UK). The Company was founded in February 1998 to exploit the market potential of the Inhibin in·hib·in n. A peptide hormone secreted by the follicular cells of the ovary and the Sertoli cells of the testis that inhibits secretion of follicle stimulating hormone from the anterior pituitary. range of products that were developed by researchers at Oxford Brookes. Inhibins are heterodimeric protein hormones that suppress the secretion of FSH (follicle stimulating hormone Follicle stimulating hormone (FSH) A hormone that stimulates the growth and maturation of mature eggs in the ovary. Mentioned in: Polycystic Ovary Syndrome, Premature Menopause ) from the pituitary. Inhibin-A consists of the alpha-subunit and beta-A chain, while Inhibin-B has a beta-B chain. In the past, assays could not distinguish between circulating bioactive dimeric Inhibin-A and free alpha subunit. By using a pair of highly characterised antibodies from Oxford Bio-Innovative Ltd., DSL has developed a two-site sandwich ELISA ELISA (e-li´sah) Enzyme-Linked Immuno-Sorbent Assay; any enzyme immunoassay using an enzyme-labeled immunoreactant and an immunosorbent. ELISA n. to specifically measure Inhibin-A. "It was a challenge to simplify the initial 'gold standard' in-house assay established by Professor Groome in Oxford, but we feel we have met the challenge with a non-isotopic, sensitive and reliable assay," said Dr. Khosravi, R&D Director. Potential research applications for Inhibin-A include, but are not limited to: (a) Menstrual studies; (b) Prenatal screening where assessment of hCG, unconjugated estriol estriol /es·tri·ol/ (es´tre-ol) a relatively weak human estrogen (q.v.), being a metabolic product of estradiol and estrone found in high concentrations in urine, especially during pregnancy. , AFP and Inhibin-A in association with maternal age and gestational age estimated by ultrasound can detect 75-80% of those with Downs syndrome (5% false positive); (c) Pre-eclampsia as Inhibin is greatly elevated in these pregnancies (d) Polycystic ovarian syndrome Polycystic ovarian syndrome (PCOS) A condition in which the eggs are not released from the ovaries and instead form multiple cysts. Mentioned in: Oophorectomy, Ovarian Cysts (e) Ovarian cancer as a possible marker; (f) Puberty studies as an indicator of maturity, and (g) IVF for monitoring the effects of gonadotropin stimulation. DSL, a Texas-based Corporation, has been established for nearly 20 years and offers more than 200 assays (isotopic and non-isotopic). DSL is an ISO9002 certified manufacturer of in vitro diagnostics and a contract laboratory. DSL maintains FDA-registered Good Manufacturing Practice (GMP) and a clinical laboratory that is CLIA CLIA Clinical Laboratory Improvement Amendments of 1988 Congressional legislation that promulgated quality assurance practices in clinical labs, and required them to measure performance at each step of the testing process from the beginning to the end-point of a certified (No. 45D0878560). DSL's main facility is located in Webster, Texas, with satellite laboratories in Sinsheim, Germany, United Kingdom and Toronto, Canada. |
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