Designed to Expedite Study of Complex Proteins, KDRI Large Protein Content Now Included with Promega HaloTag[TM] Vectors.MADISON, Wis. -- Promega Corporation in conjunction with Kazusa DNA DNA: see nucleic acid. DNA or deoxyribonucleic acid One of two types of nucleic acid (the other is RNA); a complex organic compound found in all living cells and many viruses. It is the chemical substance of genes. Research Institute (KDRI KDRI Kazusa DNA Research Institute (Japan) ) in Chiba Prefecture Chiba Prefecture (千葉県 Chiba-ken , Japan will soon offer vectors encoding Promega HaloTag[TM] with genetic content from KDRI's catalog. The KDRI content derives from large, typically difficult to clone human genes. In addition, there will be a comprehensive catalog of human transcription factors commonly used in research and drug discovery. As a result, researchers can gain ready access to the multi-functional HaloTag fused to these larger proteins. The initial offering encompasses over 1900 KDRI ORF clones in Promega Flexi([R]) vector. It includes the coding sequence cod·ing sequence n. See exon. for HaloTag, a multifunctional protein tag Protein tags are biochemical indicators. Affinity tags appended to recombinant expressed proteins can serve several purposes. They have traditionally been used as a way of purifying proteins using standard conditions rather than developing individual biochemical purifications based that can be used for cellular imaging as well as protein purification Protein purification is a series of processes intended to isolate a single type of protein from a complex mixture. Protein purification is vital for the characterisation of the function, structure and interactions of the protein of interest. and immobilization Immobilization Definition Immobilization refers to the process of holding a joint or bone in place with a splint, cast, or brace. This is done to prevent an injured area from moving while it heals. . Promega will soon launch protein arrays for functional studies that utilize HaloTag covalent co·va·lent adj. Of or relating to a chemical bond characterized by one or more pairs of shared electrons. binding properties for binding proteins to glass slides, while cellular imaging with fluorescent ligands to HaloTag is well established. The first vectors will be available at the start of 2009 through KDRI (http://www.kazusa.or.jp/kop/) and will be distributed globally. "We believe this new genomic resource will be widely accepted in the world's scientific communities, and hope this will contribute to the solution of problems in healthcare through the understanding of various gene functions which, in turn, should facilitate drug development as well," said Dr. Michio Oishi, President of KDRI foundation and Research Director of KDRI. Promega and KDRI have had a research collaboration for several years and this agreement is a natural progression from that collaboration. KDRI plans to continue to expand the genetic resource for HaloTag fusion proteins by adding more open reading frame (ORF) clones collected by an international ORFeome collaboration in which KDRI is one of the active participants (http://www.kazusa.or.jp/e/index.html). About Promega Promega Corporation is a leader in providing innovative solutions and technical support to the life sciences industry. The company's 2,000 products enable scientists worldwide to advance their knowledge in genomics, proteomics, cellular analysis, molecular diagnostics and human identification. Founded in 1978, the company is headquartered in Madison, WI, USA with branches in 14 countries and over 50 global distributors. For more information about Promega, visit www.promega.com. About Kazusa DNA Research Institute (KDRI) KDRI was founded in October 1991 as a non-profit research organization supported by the local government of Chiba Prefecture. It is located in the "Kazusa Academia Park" at the eastern edge of Kisarazu city. The main research activity of KDRI is to study genetic information encoded in DNA. In particular, KDRI is well known for the studies of plant genome sequencing, plant/bacterial metabolomics, and human cDNAs known as "KIAA KIAA Kangaroo Industries Association of Australia " clones. For more information about KDRI, please visit http://www.kazusa.or.jp/. |
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