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Depression plagues acute lung injury survivors.


Survivors of acute lung injury are likely to experience de-pression and physical impairment for up to 2 years after leaving the intensive care unit.

In a prospective study, 40% of patients had new-onset depression and 66% had new physical impairment after discharge.

The findings seem inextricably in·ex·tri·ca·ble  
a. So intricate or entangled as to make escape impossible: an inextricable maze; an inextricable web of deceit.

 linked on both psychological and physiological levels, Dr. Oscar J. Bi-envenu and his colleagues wrote. "Depressive de·pres·sive
1. Tending to depress or lower.

2. Depressing; gloomy.

3. Of or relating to psychological depression.

A person suffering from psychological depression.
 symptoms may decrease motivation for and reward from the physical activities necessary for recovery of maintenance of functioning ... [they] can also amplify symptoms of general medical illnesses, and an increased physical symptom load could negatively affect functioning."

In addition, there may be less-understood links between depression and physical functioning, wrote Dr. Bienvenu of Johns Hopkins University Johns Hopkins University, mainly at Baltimore, Md. Johns Hopkins in 1867 had a group of his associates incorporated as the trustees of a university and a hospital, endowing each with $3.5 million. Daniel C. , Baltimore, and his coauthors.

"Depressive symptoms could affect functioning through direct neurobi-ologic pathways, including neuroendocrine neuroendocrine /neu·ro·en·do·crine/ (-en´do-krin) pertaining to neural and endocrine influence, and particularly to the interaction between the nervous and endocrine systems.

 and inflammatory mechanisms."

The study comprised 2-year follow-up data on 186 patients who were mechanically ventilated ven·ti·late  
tr.v. ven·ti·lat·ed, ven·ti·lat·ing, ven·ti·lates
1. To admit fresh air into (a mine, for example) to replace stale or noxious air.

 for acute lung injury (ALI). Baseline depression was present in 21% and baseline physical impairment in 40% (Am. J. Respir. Crit. Care Med. 2011 Dec. 8[doi:10.1164/rccm.201103-05030C]).

The patients' mean age was 49 years; 56% were male. The mean length of stay in the ICU ICU intensive care unit.

intensive care unit


see intensive care unit.

 was 19 days. Patients were assessed for depression and physical function at 3, 6, 12, and 14 months after discharge. During the entire follow-up period, 40% of the patients experienced new-onset depression and 66% had new-onset physical impairment. Remission occurred in 39% of those with depression and 54% of those with physical impairment, but there was recurrence recurrence /re·cur·rence/ (-ker´ens) the return of symptoms after a remission.recur´rent

 in 20% and 14%, respectively. Most of those who developed depression or physical impairment had symptoms at 24 months (69% and 58%).

Patients who did remit tended to do well. In those with remitted depression, the mean score on the Hospital and Anxiety Depression Scale remained about 5, indicating normal mood. In those whose symptoms did not remit, the score remained 10 or higher, indicating moderate to severe depression.

Similarly, those with remission of physical impairment had a mean of 1 impaired activity of daily living, compared with a mean of 4 or more in those with unremitted impairments.

When the authors looked at potential risk factors for new-onset depression and physical impairment, only two remained statistically significant in multivariate analyses.

Education of 12 or fewer years increased the risk of new-onset depression by more than three times. Only depression at last follow-up significantly correlated with new-onset physical impairment (odds ratio, 2.7).

"Our analyses indicate that depressive symptoms are not only relatively persistent in ALI survivors, they are also an independent risk factor for subsequent impairment in physical function," the authors wrote.

"Hence, early identification and treatment of depressive states should be evaluated as a potential intervention to minimize the suffering and impairment that affect too many of these patients."


Major Finding: New-onset depression occurred in 40% of ALI survivors, and new-onset physical impairment occurred in 66%. In most, those problems persisted at 2 years after hospital discharge.

Data Source: A 2-year prospective follow-up study of 186 patients.

Disclosures: The study was sponsored by the National Institutes of Health. The authors disclosed no financial conflicts.
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Author:Sullivan, Michele G.
Publication:Clinical Psychiatry News
Article Type:Clinical report
Date:Feb 1, 2012
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