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Depression leads to increased inflammatory protein linked to heart disease.


Byline: ANI

Washington, Oct 6 (ANI): Depression leads to elevated inflammatory proteins in the human body, according to according to
prep.
1. As stated or indicated by; on the authority of: according to historians.

2. In keeping with: according to instructions.

3.
 researchers at Indiana University-Purdue University Indianapolis Indiana University–Purdue University Indianapolis (IUPUI) is the urban campus of Indiana University located in Indianapolis, Indiana. IUPUI offers undergraduate, graduate and professional degrees from both Indiana University and Purdue University. .

Led by Dr. Jesse Stewart, researchers found that depressive symptoms are associated with increases over time in interleukin-6, an inflammatory protein that predicts cardiovascular events.

On the other hand, levels of interleukin-6 were not linked to subsequent increases in depressive symptoms.

The new study is the first to examine both directions of the depression-inflammation connection and to measure the physical symptoms of depression, such as fatigue and sleep disturbance, in addition to the cognitive-emotional symptoms, such as pessimism and sadness.

While many previous studies have linked depression to increased inflammatory protein levels measured at the same time, but they couldn't speak to which is the cause and which is the effect.

"There is two-way communication Two-way communication is a form of transmission in which both parties involved transmit information. Common forms of two-way communication are:
  • In-person communication
  • Telephone conversations
  • Amateur, CB or FRS radio contacts
  • Computer networks . See back-channel.
 between the brain and the immune system immune system

Cells, cell products, organs, and structures of the body involved in the detection and destruction of foreign invaders, such as bacteria, viruses, and cancer cells. Immunity is based on the system's ability to launch a defense against such invaders.
, so we had to determine whether activation of the body's immune system sent a signal to the brain to affect mood and behavior or whether the depression activated the immune system," said Dr. Stewart.

The participants in the study consisted of 263 healthy men and women aged 50-70 years at the start of the study.

They were tested at baseline and again six years later to determine their levels of depressive symptoms and interleukin-6.

Levels of C-reactive protein C-Reactive Protein Definition

C-reactive protein (CRP) is a protein produced by the liver and found in the blood.
Purpose

C-reactive protein is not normally found in the blood of healthy people.
, another inflammatory protein, were also measured but were not related to depression.

Stewart said that the strength of the association of depression with future heart disease is similar to that of traditional risk factors like smoking, high blood pressure and elevated cholesterol.

"Promotion of inflammation may be one pathway through which depression may 'get under the skin' to negatively influence cardiovascular health. The link to cardiovascular disease Cardiovascular disease
Disease that affects the heart and blood vessels.

Mentioned in: Lipoproteins Test

cardiovascular disease 
 demonstrates that there may be physical as well as mental health reasons to treat depression," said Stewart.

The study has been published in the latest issue of the journal Brain, Behavior and Immunity. (ANI)

Copyright 2009 Asian News International The Asian News International (ANI) agency provides multimedia news to China and 50 bureaus in India. It covers virtually all of South Asia since its foundation and presently claims, on its official website, to be the leading South Asia-wide news agency.  (ANI) - All Rights Reserved.

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Publication:Asian News International
Date:Oct 21, 2009
Words:342
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