Depression; Facts to Know.
Depression afflicts more than 12 million American women each year and strikes women two to three times as often as men. Biological differences in women, such as hormonal changes and genetic factors, may contribute to higher rates of depression. Stress experienced by women from work- and family-related responsibilities, poverty or abuse may also play a role. After one episode of depression, a woman has a 50 percent chance that depression will recur at some point in her life.
Depression is not something you can just "get over." It is a complex medical condition. Depression is thought to be triggered by low levels of certain brain chemicals called neurotransmitters. Serotonin, one example of a neurotransmitter, has been identified as a major player in depression and other mental illnesses.
Prolonged stress, loss, substance abuse, some medications and certain illnesses can trigger depression in people who are susceptible to it. Depression also can occur spontaneously, without any apparent trigger.
Antidepressant medications can greatly relieve symptoms for most people who suffer from depression. Newer medications with fewer side effects have been developed in the last decade, offering more options for people with this illness.
Depression is likely to show up in more than one family member or generation.
Depression often strikes between the ages of 25 and 44; teenagers may also develop depression. It can last for weeks, months, years or a lifetime, if not diagnosed and treated. Anyone, regardless of income, education or status can suffer from this disease.
Depression often gets translated into physical complaints. It can be mistaken for other illnesses by both a health care professional and the patient herself, instead of being properly recognized and diagnosed.
About 15 percent of people suffering from severe depression will commit suicide. If not treated, depression can spiral into feelings of worthlessness, despair and suicide. Early intervention and treatment can reverse these feelings and make life seem livable again.
About eight percent to 15 percent of women report diagnosable postpartum depression, which is more severe and long-lasting than the "baby blues," within six months of delivery, and if you've had prior depressive episodes, you have a much higher risk.
Chronic but mild depression, or dysthymia dysthymia /dys·thy·mia/ (-thi´me-ah) dysthymic disorder.
A mood disorder characterized by despondency or mild depression. , is marked by low energy, a general negativity, and a sense of dissatisfaction and hopelessness. A person suffering from dysthymia may experience many of the same symptoms that occur in major depression, but they are less intense and last much longer-at least two years.
"FDA Plans to Evaluate Results of Women's Health Initiative Women's Health Initiative A 15-yr, $628 million project involving 1. An observational study of the health habits and medical Hx of ±100,000 ♀ 2. Study for Estrogen-Alone Therapy." U.S. Food and Drug Administration. "FDA Talk Paper." March 2, 2004. http://www.fda.gov. Accessed March 2004.
Effects of Estrogen plus Progestin on Health-Related Quality of Life. J. Hays et al. NEJM NEJM New England Journal of Medicine , May 8,2003; Vol. 348, No. 19.
FDA Approves Lower Dose of Prempro, a Combination Estrogen and Progestin Drug for Postmenopausal Women. FDA News (press release). March 13, 2003. http://www.fda.gov
"FDA Approves New Labels for Estrogen and Estrogen with Progestin Therapies for Postmenopausal Women Following Review of Women's Health Initiative Data." FDA News/Press Release. January 8, 2003. http://www.fda.gov. Accessed March 2003.
"St. John's Wort." National Center for Complementaty and Alternative Medicine. http://www.nccam.nih.gov. Accessed July 2002.
Hypericum Hypericum /Hy·per·i·cum/ (hi-per´i-kum) a genus of herbs, including several types of St. John's wort.
Hypericum perfora´tum the species of St. Depression Trial Study Group. Effect of Hypericum perforatum (St. John's wort) in major depressive disorder Major depressive disorder
A mood disorder characterized by profound feelings of sadness or despair.
Mentioned in: Conduct Disorder
major depressive disorder : a randomized, controlled trial. JAMA, 2002; 287:1807-14.
Shelton RC, Keller MB, Gelenberg AJ, et al. Effectiveness of St. John's wort in major depression. JAMA, 2001; 285:1978-86.
"Summit on Women and Depression: Proceedings and Recommendations." American Psychological Association. April 2002.
Grady D, Herrington D, Bittner V, et al, for the HERS Research Group. Heart and estrogen/progestin replacement study follow-up (HERS II): Part 1. Cardiovascular outcomes during 6.8 years of hormone therapy. JAMA 2002;288:49-57.
Hulley S, Furberg C, Barrett-Connor E, et al, for the HERS Research Group. Heart and estrogen/progestin replacement study follow-up (HERS II): Part 2. Non-cardiovascular outcomes during 6.8 years of hormone therapy. JAMA 2002;288:58-66.
Writing Group for the Women's Health Initiative Investigators. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial A randomized controlled trial (RCT) is a scientific procedure most commonly used in testing medicines or medical procedures. RCTs are considered the most reliable form of scientific evidence because it eliminates all forms of spurious causality. . JAMA 2002; 288:321-333.
"Women's Health Initiative," National Heart, Lung and Blood Institute. http://www.nhlbi.nih.gov. Updated Aug. 2003; accessed Aug. 2003.
The Menopause Guidebook: Helping Women Make Informed Healthcare Decisions through Perimenopause perimenopause /peri·meno·pause/ (-men´o-pawz) the time just before and after menopause.perimenopau´sal
n. and Beyond. North American Menopause Society: May 2003; http://www.menopause.org. Accessed Aug. 2003.
Public Alert on St. John's Wort. National Institutes of Mental Health. Feb. 20, 2001. http://www.nimh.nih.gov. Accessed Oct. 2001.
"Depression: Investigational Treatments" Veritas Medicine. Reviewed Jan. 10, 2001. http://www.veritasmedicine.com. Accessed Aug. 2003.
"Pharmacologic Treatment of Acute Major Depression and Dysthymia" Annals of Internal Medicine Annals of Internal Medicine (Ann Intern Med) is an academic medical journal published by the American College of Physicians (ACP). It publishes research articles and reviews in the area of internal medicine. Its current editor is Harold C. Sox. 2000; 132:738-742. Clinical Guideline, Part 1.http://www.annals.org. Accessed Aug. 2003.
Rush, A. John, et al. "Vagus Nerve Stimulation vagus nerve stimulation Psychiatry Electroconvulsive therapy
in which a pacemaker-like device stimulates the vagus nerve. See Electroconvulsive therapy. (VNS) for Treatment-Resistant Depressions: A Multicenter Study."Biol Psychiatry Vol. 47, No. 4, February 15, 2000:276-286.
For the Public. National Institute of Mental Health. http://www.nimh.nih.gov. Updated Jan. 2003. Accessed June 2003.
"Fact Sheets" National Mental Health Association. http://www.nmha.org. Date published: n/a. Accessed June 2003.
Help Center. American Psychological Association. http://helping.apa.org. Accessed June 2003.
Public Information. American Psychiatric Association. http://www.psych.org. Accessed June 2003.
"Introducing New Lexapro" Forest Pharmaceuticals, Inc. Copyright 2002. http://www.lexapro.com. Accessed Nov. 2002.
Morris M.S, et al. "Depression and Folate folate /fo·late/ (fo´lat)
1. the anionic form of folic acid.
2. more generally, any of a group of substances containing a form of pteroic acid conjugated with l-glutamic acid and having a variety of substitutions. Status in the US Population" Psychotherapy and Psychosomatics, Vol 72, No 2, 2003. http://content.karger.com. Accessed June 2003.
"Bone Loss in Premenopausal pre·me·no·paus·al
Of or relating to the years or the stage of life immediately before the onset of menopause.
premenopausal adjective Women with Depression" National Institute of Mental Health. Updated Aug. 2002. http://clinicaltrials.gov. Accessed June 2003.
"Magnets that can fight depression" Depression and Bipolar Alliance (DBSA DBSA Depression and Bipolar Support Alliance
DBSA Development Bank of Southern Africa
DBSA Dodecylbenzene Sulfonic Acid
DBSA Direct Broadcast Satellite Association
DBSA Dual-Band Slot Antenna
DBSA Deployed Baseline System Architecture ). Aug. 20, 2003. http://www.dbsalliance.org. Accessed Aug. 2003.
"Rates of Dementia Increase Among Older Women on Combination Hormone Therapy" NIH News, May 27, 2003. http://www.nih.gov. Accessed Aug. 2003.
Caspi, A. et al. "Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene." Science, vol. 301, pages 386-389. July 18, 2003.
"Depression & Women" National Women's Health Report, Vol. 25, No. 4. Published Aug. 2003. National Women's Health Resource Center. Accessed Aug. 2003.
Kessler R.C., et al. National Comorbidity Survey Replication. "The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R)." JAMA. 2003 June 18; 289(23): 3095-105.
Lexapro [package insert]. St. Louis, MO. Forest Pharmaceuticals. 2002.
Keywords: depression, women, stress, suicide, medications