DelSite granted United States patent for a wound healing technology using combination of growth factors and protease enzymes.Carrington Laboratories, Inc. (Irving, TX) announced that its subsidiary DelSite Biotechnologies, Inc., has been granted the United States Patent 7,202,066 titled "Combination of a Growth Factor and a Protease Enzyme" for an advanced wound healing technology. DelSite Biotechnologies, Inc., Carrington's wholly-owned subsidiary, is developing and commercializing GelSite polymer as a controlled-release drug delivery technology for protein/peptide therapeutics and vaccine products. This United States patent covers an important discovery for DelSite in the field of wound healing. Chronic wounds, including pressure ulcers, venous stasis ulcers, and diabetic foot ulcers, are difficult to heal and occur more frequently among elderly individuals, usually with decreased immune functions. Treatment programs are often not optional because in such wounds, the growth factor and/or protease functions are often abnormal. Thus, this novel growth factor and protease combination that stimulates both cell proliferation and cell migration could provide an effective solution in enhancing the healing of such wounds. The patent relates to a novel stable combination of KGF kgf abbr. kilogram force and an extracellular matrix-degrading protease enzyme in which KGF is not degraded and remains functional. KGF plays an important role in the wound healing process and stimulates the proliferation of epithelial cells, including the skin keratinocytes Keratinocytes Cells found in the epidermis. The keratinocytes at the outer surface of the epidermis are dead and form a tough protective layer. The cells underneath divide to replenish the supply. that forms the outmost out·most adj. Farthest out; outermost. Adj. 1. outmost - situated at the farthest possible point from a center outermost layer of the skin. On the other hand, the protease clears the wound debris to facilitate cell migration and hence wound closure, thus achieving a synergistic effect with KGF. "The growth factor and protease combination technology covered under this patent represents a new and novel treatment solution for wounds," said Dr. Yawei Ni, senior scientist at DelSite Biotechnologies. "Importantly, DelSite has also developed the delivery technology for this combination treatment using its GelSite polymer technology. The polymer has been demonstrated to be highly suited for the topical delivery of therapeutic agents to the wounds." DelSite's leading delivery platform, the GelVac nasal powder vaccine delivery system, is a simple and broad vaccine delivery platform suitable for many different classes of vaccine antigens. GelVac is currently being evaluated as a delivery system for H5N1 pandemic influenza vaccine and is partially supported by a NIH/NIAID Challenge Grant. GelSite polymer is a naturally sourced, high-molecular-weight anionic an·i·on n. A negatively charged ion, especially the ion that migrates to an anode in electrolysis. [From Greek, neuter present participle of anienai, to go up : ana-, ana- polysaccharide polysaccharide: see carbohydrate. polysaccharide Any of a large class of long-chain sugars composed of monosaccharides. Because the chains may be unbranched or branched and the monosaccharides may be of one, two, or occasionally more kinds, that exhibits distinct chemical and functional properties proprietary to the company. GelSite is water-based and is capable of in situ gelation gelation /ge·la·tion/ (je-la´shun) conversion of a sol into a gel. ge·la·tion n. 1. Solidification by cooling or freezing. 2. The process of forming a gel. 3. , i.e., changing either a solid or liquid formulation into a gel upon contact with body fluids that leads to controlled-release of active biomolecules This page aims to list articles on Wikipedia that describe particular biomolecules or types of biomolecules. This list is not necessarily complete or up to date - if you see an article that should be here but isn't (or one that shouldn't be here but is), please update the page . GelSite is not an adjuvant and is a member of a family of plant polysaccharides classified by the FDA FDA abbr. Food and Drug Administration FDA, n.pr See Food and Drug Administration. FDA, n.pr the abbreviation for the Food and Drug Administration. as Generally Regarded As Safe (GRAS GRAS - A public domain graph-oriented database system for software engineering applications from RWTH Aachen. ). The polymer is currently manufactured to cGMP standards at Carrington Laboratories wholly owned subsidiary Wholly Owned Subsidiary A subsidiary whose parent company owns 100% of its common stock. Notes: In other words, the parent company owns the company outright and there are no minority owners. , Sabila Industrial, SA. The GelVac system is a nasal powder vaccine delivery platform based on GelSite polymer. Dry powder formulations delivered nasally provide several potential advantages, including better stability, room temperature storage, no need for preservatives, no need for needles and muco-adhesiveness. Nasal immunization induces both systemic and mucosal immune responses. The GelVac delivery system increases antigen nasal residence time, providing for prolonged contact with the mucosal surface which may improve immune response for many different classes of antigens. Carrington Laboratories is an ISO (1) See ISO speed. (2) (International Organization for Standardization, Geneva, Switzerland, www.iso.ch) An organization that sets international standards, founded in 1946. The U.S. member body is ANSI. 9001-certified, research-based, biopharmaceutical and consumer products company currently utilizing naturally-occurring complex carbohydrates to manufacture and market products for mucositis, radiation dermatitis, wound and oral care, as well as to manufacture and market the nutraceutical raw material Manapol and cosmetic raw material Hydrapol. Carrington also manufactures and markets consumer products and manufactures quality products for other companies. Manufacturing operations comply with cGMP standards. Carrington raw materials are from organic- certified plants, and Manapol has the DSHEA DSHEA Dietary Supplement Health and Education Act of 1994 (US legislation) claim of enhancing the immune system. Carrington and DelSite technologies are protected by more than 130 patents in 26 countries. Select products carry the CE mark, recognized worldwide. Carrington Laboratories, Inc. +1-972-518-1300 www.carringtonlabs.com DelSite Biotechnologies, Inc. www.delsite.com |
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